DMSO
NATURE'S HEALER
Dr. Morton Walker
(German translation of the original US edition)
Table of Contents:
Vorwort
Chapter 1
Das painkillers with a problem
Der new medical breakthrough in pain
Die dislike the FDA over other applications DMSO
Fehler in FDA procedures
Chapter 2
Die controversial past of DMSO
Der origin and provenance of dimethyl sulfoxide
Die FDA enters the picture - The controversy began ...
Die public rebelled against the FDA Restriktierungen
Der legislature acts on behalf of the people
Das new painkillers gained media fame
Chapter 3
Das therapeutic principle of DMSO
Die structure, as well as the physical properties of the
molecule
Die healing power of DMSO
Nichttechnische summary of molecular properties
Wirkstofftransporteigenschaften of DMSO
Die main pharmacological effects of DMSO
Wie DMSO is applied topically
Wie DMSO is supplied
Chapter 4
Generelle medical applications of DMSO
Generelle applications of DMSO
Schutz against radioactivity, freezing and thawing
Verletzungen of the brain and spine
Hämmorhagischer stroke and head wounds
Gehirngeschädigte children
Ischias and disc problem
Keloide, scars and burns
Antifugale, Antibacterial, Antiviral action
Muskuskelettale injuries
Krebs
Diabetes
Nasale sinusitis, tic Douloureaux, headache
Hautkrankheiten, ulcers, and herpes
Katarakte and other eye problems
Das asthmatic syndrome
Schwangerschaft after tubaler obstruction
Verschiedene applications of DMSO
Chapter 5
Die toxicity and side effects of DMSO
Die laboratory studies on the toxicity of DMSO
Augenveränderungen who controlled the spell of the FDA
with it
Traten Lens changes on humans?
Die undesirable side effects
Die overcoming malodorous DMSO side effect
Die condemnation of other side effects
Chapter 6
Die potent drug for sports injuries
Das healing of sports traumas
Ein limb that has been rehabilitated
Professionelle Sport Team doctors use DMSO
Doppel-blind studies in sports
Die players see a need for DMSO
Chapter 7
Arthritis treatment with DMSO and diet
Die incidence of arthritis
Die official position of the Arthritis Foundation
Das protocol for DMSO arthritis therapy
Die impermeable covering technique
Die DMSO anti arthritis diet and dietary supplements
Protein milkshake
Entgiftung
Der Manner cocktail for arthritis
Berichtete Arthritis DMSO research
Chapter 8
Das Customizing DMSO to foot and leg problems
Platzieren of DMSO in the Foot Care Medicine
Bunions the big toe
Hammerzehen
Arthritis the feet
Harte and soft corns
Schwielen
Plantarwarzen
Eingewachsene toenails
Club nails
Nagelpilz
Athletischer foot
Fußgeruch
Tänzerfuß
Metatarsalgie
Senkfuß
Fersensporn
Knöchel sprains
Chapter 9
Die application of DMSO in injuries of the head and spine
DMSO research on reversing neurological disorders
Das emergency therapeutic principle
Tierexperimente in which DMSO is used in brain embolism
Zusammenfassung of knowledge on the application of DMSO on
central nervous system
Das potential in the treatment of myasthenia gravis, and
other
disturbances
Die treatment of intracranial hypertension
Multiple sclerosis successfully treated
Chapter 10
DMSO therapy for mental illnesses
^
foreword
During the weekend of February 14th 1981 held the American
Medical Association, a conference of its executives from, and one of the
speakers was Otis R. Bowen, M.D. Dr. Bowen is a former governor of Indiana, and
chairman of medicine, management and policy. With its presentation to the AMA,
he shocked the meeting when he admitted to have taken the law into his own
hands, and to use an illegal drug to his wife to ease the pain, when she was
dying. Beth Bowen died on 1 January 1981
multiple myeloma, a form of bone cancer.
Dr. Bowen, the then planned withdrawal from the
governorship, moved to dimethyl sulfoxide, or DMSO to facilitate the severe
pain to his wife. He received the liquid solvent by a veterinarian, and he
found out that this substance the suffering of his wife "within
minutes" soothed. The Food and Drug Administration (FDA) prohibits the use
of DMSO in humans, with the exception of the treatment of a rare bladder. Even
with the ban by the government in mind, did Dr. Bowen what he considered his
wife to be right, he gave her DMSO intravenously. "Why can not people
dying with severe pain not get a prescription in order to obtain the means
simply" he asked in his speech. "The only justification that I could
find was that it could cause only in the dog cataracts after prolonged use or
at high doses." Before you continue to read in this book, makes you to
perhaps similar questions as Mr. D. Bowen. It would not be difficult to
identify with the patient, which are involved here, some of which were forced
to take treatment into their own hands and go to the DMSO.
Indeed, DMSO was never found in the human use is unsafe. The
side effects are only minor irritations. DMSO stops bacterial growth. It eases
pain. As the vasodilator DMSO enlarged small blood vessels by increasing the
circulation to an area. It softens scar tissue and soothes burns. The effect of
anti-inflammatories DMSO relieve the swelling and inflammation of arthritis,
bursitis, tendinitis, or other muscular skeletal injuries. It also accomplishes
many other goodies therapeutic nature for everyone, injured or sick ist.Ich of
recommending that you should apply DMSO strictly under the supervision of a
doctor who is familiar with its usage. Only pharmaceutical grade DMSO should be
used, not the technical crude.
DMSO is a medicine as well as a good solvent. The industry
uses it to color and to remove coatings, as well as to dissolve certain
plastics such as polyvinyl, Cloride, methacrylate and acrylic. It does not
affect cotton, wool, nylon, leather and polyester. More important is that it
uses the human body cells, tissues, and organs in various ways is. DMSO is the
newest healing principle of the 21st century with a wide range of applications.
It provides an entirely different possibility is to treat diseases - not like a
normal drug, which acts only in a particular disease, it is a holistic
approach, which brings back the entire physical cell function to normal.
Dimethyl sulfoxide has a confused 30-year history. But because of the general
public outcry over its ban, DMSO was the colloquial term, and to verursachtem
by medicine or politics Celebre. Those of us who could have used the funds
already since 26-28 years, never dreaming that the DMSO is the focal point in
the struggle between individual freedom and the power of the government. I and
my colleagues have been criticized in some medical circles for conveying and
applying the DMSO, mocked and even persecuted. But I, and the others came to
the conclusion that it is the only way to get a true revolutionary treatment
system for patients, in other words to the general population, the information
medium. That is the purpose of this book. Much of my material will seem the
scientists anecdotal, however, the language understood by the public is the
best. Sometimes a hundred patient stories that a sensitive and intelligent
doctor has listened better than a double blind research project. Double-blind
studies are often only on one side. Everyone who participates is blind, and
remains there, until on the way there, where then many years, and thousands of
patients later found that the particular drug does not work, or is too toxic to
guarantee its application. Good recent examples of toxic drugs are arthritis
drugs Motrin, Tolectin, Naflons and Naprosyn. They have all been subjected to
extensive double-blind studies. They are all weak organic acids and
ProstglandinHemmer as aspirin. About as effective as aspirin these 4 drugs have
two major differences: they are more toxic than aspirin, and cost 10 to 30
times more money. So much for the double-blind studies. Whether you agree or
not with the current facts, it is as if one would argue that if a drug has been
found to be safe, doctors can use the drug safely when the opinion would he
would help their patients. With all the extremely dangerous and potent drugs
that are on the market, it is absurd to keep such an effective product as DMSO
from Aphotekenregalen. Certainly not prove all claims to the DMSO to be valid,
but in my opinion already many true have proven. And the most dramatic use of
the drug has yet to be discovered may. Another purpose of my book is to point
out the many uses of this unique substance. If DMSO been endorsed for use in
all countries, and it would produce for topical, parenteral or oral
administration, people do not need it in poor cleanliness in their homes
smuggle it aufzustreichen their arthritic joints. Possibly DMSO will find its
place in the armor of American medicine. We who believe in this material want
that this happens sooner rather than later. The clinical Evulation the DMSO
started in the US in 1963, and until now, 1992, the FDA has only approved the
drug for only one application. This situation gives rise to some fundamental
questions that run like a thread through this book. How do we get to look the
FDA to on their outside the box? How can we bring either DMSO to the people, or
how can we account for all the material at one time? You will find many answers
to these pages. The theme DMSO needs more pressure from the public, then this
process would accelerate.
We want doctors are able to prescribe DMSO, without the fear
of reprisals by the medical world, as well as the hospitals that employ them.
Failure to do so, it would be our will must be ensured that pharmaceutical
grade DMSO for patients could be made available. When I wrote the book, I found
out that doctors clearly exercised restraint that their names be mentioned in
connection with DMSO. They often asked me euphoric success reports on the DMSO
treatment available, but their fear of collegial criticism prevented me to
publish their identity. I had to reject such reports, and there were hundreds
of them. DMSO has the highest potential of applications that has ever been
documented for a single chemical. My wish is that this book will bring more of
them in the public, as are currently allowed. It is to everyone understand from
the outset that I do not claim that the substance would be a kind of miracle
cure. Properly said DMSO is a very effective and versatile compound that has
been successfully adapted to a large number of health problems. I want that
knowledge is passed on to as many people, so that complaints and diseases for
which DMSO is appropriately be alleviated. I hope you agree with me that this
is a worthy goal for me.
Morton Walker, D.P.M.
Stamford Connecticut
^
Chapter 1
Chapter 1
The painkiller with a problem
In late spring 1980, Eva Lee Snead, M.D., then a family
practice specialist in San Antonio, Texas, learned that your friend, a 32
year-old psychologist Marjorie Saloman should undergo a hysterectomy to remove
her uterus. The problem of the genital system of Mrs. Saloman originated from a
stenosis of the cervix. This condition is a narrowing or stricture of the mouth
of the neck - the opening of the uterus leads to the vagina. The Psychiologin
told Dr. Snead various unsuccessful attempts at treatment by cervical
dilatation, performed by her gynecologist. He tried to calm by injektizieren of
local anesthesia the cervix at its lower quadrant. This anesthetic technique is
usually simple and effective, however, this method brought the woman no help,
not even after many attempts. Mrs. Salomans gynecologist admitted that for them
the trial of cervical dilatation had failed. The pain was so strong for the
patient that has been introduced as the Dilatationsinstrument, this powerless
has been. Her gynecologist removed the instrument
immediately, as their anesthesia the pain could not suppress. eliminate None of
his treatments to the problem worked, surgical removal of the uterus was the
next candidate method. Dr.Snead asked your girlfriend to wait a week before
they would undergo the hysterectomy, provided the gynecologist would agree with
the delay ... Given this, Marjorie Saloman asked their doctor to call Dr.Snead
to the medical background in experience bring. After replacing some of the
principles of DMSO treatment, convinced him Dr.Snead the substance to be
combined with vitamin E and applied topically it in the cervical region of the
patient. Dr Snead wanted to try to reduce the scar tissue and adhesions of
women, including the DMSO is also capable. "I was happy to go to the
Gynäokologen on the day on which we the DMSO administered" wrote Dr.
Snead, "He led her substance with vitamin E for yourself. Before With 5
minutes to slid his instrument into the cervix without a perceived by the
patient sensation. "A month later, the gynecologist checked again the
constricted cervix of the woman and found out that this was still overly tight.
He repeated the use of DMSO and vitamin E, after a few minutes it was possible
to introduce the instrument, and the opening without trouble wide. This time it
was a very successful procedure, the surgery date was canceled.
The patient was now wearing a device in itself, which had
been introduced to the walls of the cervix to keep dilated. Meanwhile Dr.Snead
led with your girlfriend through a mega vitamin therapy using high-dose
nutrient substances in order to restore health to the surrounding tissue. A
month after the device is inserted, the woman was untersúcht again from
gynecologists, he found that the cervix was dilated perfect. He was able to
introduce in probes without first administer DMSO or another anesthetic agent,
without any discomfort to the patient. Majorie Saloman was definitely keeps
saying remove the uterus before hysterectomy. They had Dr.Eva Lee Snead
withdrawn their medical license to practice as they should be repeated call
with DMSO and other forms of alternative medicine beschäftigteWas some as
"quackery" properly be considered as an alternative healing method
into consideration. The state of Texas is not willing to allow deviations from
the medical mainstream. And as you see, the use of dimethyl sulfoxide of
Predictive physicians located outside the medical teams Main. Lorae Avery,
director of the Health Center, Inc., an acupuncture and nutritional clinic in
Auburndale, Florida expressed their astonishment towards me on the
effectiveness of DMSO to eliminate pain out. She saw excellent results, as
doctors working for the Health Center, the substance administered externally to
the patient. One of them was the 65 year old Anna Goldeman who suffered from
bursitis in his right shoulder for years. They came to the health center to
relieve bursitis in November 1980, and was satisfied with the results of DMSO
treatment. Dramatic as the alleviation of shoulder pain was the relief of
symptoms, which began 4 years ago. Mrs. Goldeman then underwent an amputation
of the right hip higher in the groin, whereupon a phantom limb pain occurred.
After the amputation of a limb or a part thereof, the amputees made the strange
experience, as if the limb is still there. This feeling of phantom pain is
generally referred to as a butt-hallucination. It arises from different types
of nerve stimulations, acting as burning, prickling, tingling, pricking,
tickling or really severe pain. Such sentiments are not unusual for an amputee
and are not easily treatable. With the application of DMSO on her right
shoulder of phantom pain disappeared along with his constant twitching of the
left groin of Mrs Goldeman. She felt no longer that she had a Extremetät. Now
she could be satisfied with your situation. Dr. Avery said: "We did not
attempt to treat the phantom pain, our doctors were worried because of
bursitis. Nevertheless, the phantom pain disappeared through the application of
DMSO on the shoulder of the woman. The use of DMSO at a part of the body load
obviously in another part of the body a phantom pain disappear. And this stayed
away permanently.
When I am 10 years later when Dr. Avery asked again, I
learned that mrs. Goldeman still took advantage that the DMSO was available for
them to quench their pain whenever she needed it. Murray Franklin, M.D. From
Chicago, is a professor of medicine at the University of Illinois and the
medical director of the Union Health Service, the largest medical program in the
state of Illinois. He got a delivery DMSO in autumn 1980 and decided to try it
for the benefit of some patients where previously nothing had helped. One of
the patients who received topical therapeutic applications, Lucas Sheinholtz
was 52 years old, he had complaints of rheumatoid osteoartritis both knees for
more than a decade. Mr. Sheinholtz hummpelte using two sticks when he arrived
at the practice of Dr. Franklin, it was difficult for him ever to see a doctor.
The patient had previously received many injections with cortisone, which
administered his regular doctor routinely. However, no improvement of his
arthritis was found neither the patient nor the treating physician. "I
suggested to the doctor the man aufzupinseln something DMSO on both aching knees."
Said Dr. Franklin. "His right knee was swollen 3, his left not. The right
knee felt when touched warmly. His doctor agreed to the therapeutic trial, I
administered the DMSO in three applications. Since I did not know exactly how
the solution was to use, I always ran dry application and carried it on again
and again. Within 15-20 minutes the patient said he felt no pain, and was going
to be able to use without a stick. "He came back a week later and said
that his pain in his left knee was completely gone." Dr. Franklin
"There was no pain in his left knee more. The pain in the swollen right
knee was a little back. I applied the DMSO again, and the man got a similar
result within a quarter of an hour. No more pain! I have not seen him since, and
suppose he feels well. "
^
The new medical breakthrough in pain
Mankind has a new medical breakthrough in pain:
Dimethyl sulfoxide called DMSO. When used alone or in
combination with other medicinal substances to be treated with dimethyl
sulfoxide in a position almost every Kankheit, which is known to man. The
substance, a byproduct of the pulp or paper manufacturing, has been safely and
successfully used by millions of people around the world in order to control
swelling, as well as to reduce discomfort, to remove inflammation, the growth
of bacteria, viruses or fungi to slow down, or they kill like in many cases. It
heals burns and relieves sprains and strains, and arthritic joints. It
effectively works with cataracts, sports injuries, scleroderma, myasthenia gravis,
tuberculosis, and even diminished mental retardation in people with Down
syndrome. Cancer seems to respond well to DMSO. In Mount Sinai Hospital in New
York City, walked Charlotte Friend, M.D. Cancer cells. In normal body cells to
harmless by bringing them into contact in a test tube with DMSO solutions
Consequently, the Krebsforchung underway. In November 1988, in the Journal of
Chlinical Oncology reported that twenty cancer patients with extravasation of
anthracyclines (destructive secretions from the tissues of toxic
chemotherapeutic anthracycline with the potential to form cancerous tumors in
the skin of the recipient) were treated in a pilot study by topically
administered 99 liquor DMSO. The patients were three months under observation
by a regular examination, also were photographs taken. The DMSO was applied
about twice those affected by the extravasation area, then dried in air. This
was repeated every 6 hours, the project took 14 days. The initial symptoms of
extravasation include swelling, redness, and pain. The average size of the
damaged area of the skin of these patients was 25.8 square centimeters (cm2),
and average elapsed 25 minutes through the extravasation and application of
DMSO. No patient extravasation leading to ulceration, or surgical interventions
were necessary as it would have been usual with these toxic cancer
chemotherapeutic agents. The authors of the report are not sure about 95
percent that Ulkeration had occurred only in 17 percent of patients. They
further reported that in these 3 months in half of the patients no residual
damage had occurred while a pigmented indurated area remained in tens. The only
side effects of DMSO are a burning sensation in the application, sometimes
associated with itching, redness, and sometimes scaly. Slight blistering
occurred in four patients, six reported a characteristic odor, which is
comparable to that of oysters. The oncologist said that topical DMSO is a safe
and effective treatment for cancer-related Antracykline extravasation. DMSO tends
to prevent the formation of scar tissue, or simply dissolve. The contracture of
the scar tissue, as normally occurs in a combustion does not take place.
Chilean doctors have published their results on the use of the substance
dimethyl sulfoxide, which indicate that it reduces the frequency of angina pain
or Herzatacken.
It is the DMSO ascribed to prevent damage to the heart
muscle, as it has been tested on animals. With the use of stroke DMSO could be
life-saving, as well as when used shortly after a heart attack. Investigations
are continuing. Studies from Chile also show that it is in DMSO to a penetrants
(feed) is that crosses the blood-brain barrier. It transports drugs against
various forms menthaler diseases effectively directly into the brain. When introduced
into the nostrils may open within minutes blocked sinuses. It transported into
the middle ear to reduce antibiotic deep infection. It does the same against
viruses and reduces Syntome of herpes zoster (shingles) and herpes simplex
(cold sores). The viruses Vedas hit by antiviral drugs, which are transported
by the DMSO. In addition, herpes II, the sexually transmitted disease,
significantly improved by the administration of DMSO directly to the genitals.
In Poland periodontitis was healed, gum disease and tooth decay, and reduces
the associated pain, affected by brush on of DMSO in the fields. Some pioneers
among dentists sprinkle it in empty tooth socket after a tooth extraction,
especially in wisdom teeth. It stops the swelling after drawing.
the treatment of patients with generalized periodontitis by
indomethacin in a DMSOLösung was described in a paper from 1987, which comes
from Russia. Periodontal disease is a disease of the structures that support
the teeth, such as the gums, Paradontalmembran and the alveolar bone. The
effect of bacteria on food waste, accumulated around the margins of the gums,
causing the formation of plaque, which eventually forms a hard deposit tartar
(or stone). This is deposited in the gingival tooth gaps (the space between the
gums and the surface of the teeth), which is enlarged to form abnormal gingival
pockets. This is an early stage of periodontitis. Chronic gingivitis gums
marked by chronic inflammation, it swells and bleeds easily. Stone is deposited
in the pockets gingivialen and causes bleeding and ulcers. Left untreated, the
plaque spreads to the underlying Paradontalmembran and the alveolar bone, which
are destroyed. At this stage of periodontitis, the teeth become loose and may
fall out also. The disease Periodontal disease is the most common cause of
tooth loss in people mitleren age and older. It is caused by low oral hygiene,
ill-fitting dentures and by poorly prepared artificial crowns and fillings.
Early stages of periodontal disease are treated by removal of tartar and
polishing to remove the plaque, combined with a thorough oral hygiene. In
advanced disease the gingivivalen bags by gingivectomy (removal of gum) are
surgically removed. Now the periodontitis has been treated by a combination of
indomethacin and DMSO. Indomethacin is a drug with anti-inflammatory,
antipyretic, and pain-killing properties, but it does not contain
corticosteroids. Its mechanism of action is unknown, unlike other
anti-inflammatory drugs. Prior to this Russian publication clinical results
have been reported on the treatment of hemorrhagic form of periodontal disease
from Bulgaria. The hospital staff used a complex herbal extract, and 15 percent
DMSO to free their patients from periodontitis. American Podiatric Medical
Association (foot specialists) have discovered DMSO for effective treatment of
painful corns, calluses, ingrown toe nails, bunions, hammertoes, heel spurs,
and even of gouty big toe. Inflammation, like pink eye (pink eye), caused by
the invasion of viruses, disappear after a few DMSO applications. All this is
done in a manner that does not yet fully understand the medical scientists.
They do not like DMSO actually works. For this reason 6 DMSO is initially by
the US food and drug association (FDA) does not not approved for use in humans,
caused except for the treatment of interstitial cystitis, a condition of
scarring and gradual disappearance of the bubble. Bruce H. Stewart, M.D., of
the Cleveland Clinic Foundation, and Sheridan Shirley, M.D., of the University
of Alabama, administered DMSO at
213
Patients and found that it cured the disease of the bladder
soon, although the patient on
Patients and found that it quickly healed the bladder
disease, although the patients have not responded to traditional treatment
methods. Before success by DMSO people who were suffering from interstitial
cystitis were faced either with a larger surgical procedure performed on the
bubble, or even with the absolute removal. They suffered having to urinate
every 10 minutes under the pressure. Unlike the criteria to studies for the use
of DMSO with other problems, the study of interstitial cystitis was only
manufactured for a simple protocol: Patients were sick, did not improve
spontaneously, and all kinds of Treatmen t were ineffective. Then they received
DMSO and improved markedly. DMSO eliminated the health problems of the people,
and got an approval by the FDA for treating bladder But only for interstitial
cystitis.
^
The reluctance of the FDA over other applications DMSO
"The fundamental problem with the FDA established its
position, was the Qalität scientific information that has been provided to the
details that have been made over the DMSO to underpin" said J.Richard
crout, MD, Director of the Department drugs, the food and drug Administration
FDA. Dr. crout issued this opinion, after the House Select Committee on Aging
on th 96 Congress, which was held on March 24, 1988 belongs. Dr Croud
continued: "I want to make it clear that the FDA has allowed DMSO for
symptoms, for which a proof was given that met the legal requirements. We are
willing to allow for any other applications, unless proof is provided that it
meets the legal standards. "In short, the drug can be approved if clinical
researchers offer substantial evidence of the effectiveness of DMSO, and
compared to the FDA substantiated by well-controlled studies. Only the
"Warscheinlichkeit" which is DMSO effectively, is in accordance with
the present laws, just not enough. For this reason, the only problem that
prevents an FDA approval for DMSO for all other Eisatzmöglichkeiten, the lack
of well-controlled studies that meet the statutory requirements, Dr.Crout said.
There is a fundamental conflict between the Qalität scientific findings that
are available, as well as the legal requirements that are necessary for a
permit. This fundamental conflict can best be demonstrated on the approval of a
new drug. Its application was submitted in 1978, of the Research Industies
Corporation of South Lake City, Utah, the largest producer of human health
online DMSO, at the concentration of 50 percent, called Rimso50. The
manufacturer Resserch Industies Corporation wanted to expand the applications
of its product on the relief of pain and ulcers on the fingers of patients with
scleroderma. Scleroderma is a rare collagen disorder that manifests itself by
the thickening of the skin caused by the swelling of the connective tissue.
Most hands are affected, specifically caused this disease ulcers on the
fingers, less commonly to other body tissues. After a detailed assessment by
the staff of the pharmaceutical division of the FDA and its Arthritis Advisory
Committee re-registration was refused, allegedly on the grounds that the
available clinical trials failed to prove that DMSO is effective against
scleroderma. The recent research methods of medical science used double or
single-blind studies, which did not seem adequate for evaluating the
effectiveness of DMSO as in this example.
Research Industries Corporation was mainly based on a
specific study to prove the effectiveness of DMSO against scleroderma. In this
study, each patient had to dip a hand in a DMSO solution. The untreated hand
was observed for the control. Both hands had ulcers on the skin of the fingers,
the researchers were of the opinion, the ability of DMSO to heal ulcers
Sklerodemische would be clearly shown on the what happened to his hands.
Dr.Crout, described what happened. "There were many patients a general
advance in the healing of ulcers on the fingers, in some it was quite striking.
Anyway, it is interesting to note that this progress took place on both hands
of scleroderma; both hands, the treated and the untreated hand commenced to
heal. Well, DMSO is different from all other known medical substances by the
very fact that it is easily absorbed into the body. Brushes a lot the size of a
silver dollar anywhere on your upper body, in 30 seconds, you will taste it on
your tongue. It penetrates the skin and migrates quickly through the
bloodstream. The functionaries of the Research Industries Corporation argued
that both hands of patients healed because the DMSO equally contributed to the
hand that had contact with the solution, as well as on the control hand. Simply
put healed DMSO control hand through its spread in the bloodstream to the site
of ulcers. The inclusion of the substance into the body through 8, the treated
hand was inevitable because of the unique characteristic of the penetration.
Current techniques that are used for scientific methods of today, can not be
applied in a study of the DMSO. Dr. crout continued: "Our staff, as well
as the advisory committee came to the conclusion that by improving the
untreated hand it was very probably that it is the entire healing trend in the
study to could act a the nonspecific DMSO such an effect. Everyone was in
agreement with the fact that the study showed that DMSO would be effective, but
few believed that the study proved this point. "The legal standard for
approval of a drug is the very substantial evidence of effectiveness through
well-controlled studies, not the existing possibility of effectiveness."
Continued the FDA chief, "We are unable to allow the DMSO for this
application at this time . "to be recognized as a drug by the FDA, it has
the §505 of the Act on Life, pharmaceuticals and cosmetics correspond, in the
stands, that the effectiveness of" must be demonstrated substantial
evidence. " This means the evidence must be done by controlled clinical
studies, carried out by experts who are qualified by scientific training and experience
to prove the effectiveness of drugs. Dr.Crout explained that the requests for
an investigational new one
Drug have been submitted for the DMSO, the last 18 years
were deficient. They were not introduced with scientifically designed studies.
They came to not secure discipline that is required by the research. All
applications for admission must have a FDA standard procedure through to get a
permit. The previous investigational new drug applications of three
pharmaceutical companies with a national reputation were badly prepared,
Dr.Crout said, also did not know the companies as they appear the
had to present applications to the FDA to prove the value of
the DMSO application. He made this statement despite the fact that the same
pharmaceutical companies have previously received approvals for other drugs.
^
Error in FDA procedures
Of course, the pharmaceutical companies did not agree. The
co-discoverer of the therapeutic properties of DMSO, Stanley W.Jakob, M.D.,
associating professor of surgery at the Medical School of Oregon was certainly
not agree. He was of the opinion that the advisory committee that made
recommendations to FDA approval of DMSO, was prejudiced against the DMSO. Dr
Jacob made the House Committee on Aging following message: ". I am not satisfied
that the FDA has the DMSO added quite a shock" The DMSO researcher who
worked with patients from case to case, pointed out, that was the FDA advisory
committee set negative to the DMSO. The committee members had never used DMSO
itself as a therapeutic agent. This was admitted by Dr. crout. The Honorable
Claude Pepper, former chairman of the House Select Comittee on Aging tended to
agree with the analysis of Dr.Jakob. Congressman Pepper said Dr. crout
following with: "If a drug with enormous good prospects by three
pharmaceutical companies is happened to you, who obviously thought that the
medicine would considerable potential, I would in a case like this, think that
you would be eager to see whether the requirements that were asked, are
justified. You should look for a suitable detection, which is in line with your
conscience and your judgment will be that the product could be many people
provide relief and should be placed on the market. "Well, the public, and
most Myself, agrees relationship way think that has many people denied relief
your device with the desire to be cautious, and the desire that is no damage,
in the fear that they allows that the drug is approved, as it was presented, as
people could be harmed by it; You have such a negative attitude towards the
application that they do not even share the company on the informative way they
could try to correct themselves; They are not interested to take account of the
user in the country that could benefit from the resources and to obtain the
benefits from it, "said the congressman. They say "it is not our
beer," as the old saying is, if these people can not comply with the
formalities. This is the law, it is not up to our responsibility. Let them take
a better lawyer. We do not keep it going. We sit around here just trying to
protect the public interests. "Are you sure this is not a justification
for the public or for members of Congress?" Asked Congressman Pepper.
"Are you sure that there is no reason for these allegations?" Dr
crout read the objections other than eight, but he hinted indirectly that DMSO
had trouble because it was so unorthodox. He said it would be much easier for a
new drug to obtain approval for use if there is something already-available on
the market would be closer, such as a new antibiotic or sedative that replaces
an existing. DMSO is a substance that is completely alien to medical science.
It has a new type of procedure that can not be understood in accordance with
our existing Medications. There is a total of a new principle that, in
circumstances which will revolutionize Therapheutik 10 when it once explored in
a more sophisticated manner. Until now, DMSO was not explored by specifying a
double or single-blind studies, which were commonly used in science. That is
the current problem. And this has confused the medical community, since the
first time it was discovered that DMSO has a therapeutic benefit, oppose human
injuries, as well as to cure human diseases.
The existence of this anti-inflammatory painkiller raises
the following questions: How can it be established with conviction, so that
helps on the extent to which DMSO at the many luxurious and different symptoms
reported in the medical literature is that it can be successfully used by
clinicians? Are we able to break through the blockade, which allows a federal
authority to keep this medicine from general use because its research studies
are not with the regulations compatible, which were determined by the same
Federal Government to protect its citizens? Has DMSO a controversial past this
substance differs from the known principles of Medications Between the
frontiers of healthcare and medical bureaucracy, because none of the groups in
truth understood how radical. Must DMSO remain controversial?
^
Chapter 2
Chapter 2
The controversial past of DMSO
On 10 November 1980 entered employees the FDA office of Dr.
Stanley Jacob at the University of Oregon Health Sciences Center. Investigators
searched for reports on possible damage to the human eye through the use of
DMSO. They had a search warrant, one issued by a federal judge, and were
prepared to rummage through the files of Dr. Jakob and confiscate. William
Zuber and Dr. Alan B.Lisook FDA has any access to the document denied despite
the impending raid. Instead answered Jacob lawyer, Jay Geller, the measure
point by point in federal court. Mr. Geller told, informed that such reports do
not exist, and if they do, that any were in Jacobs possession. Geller added
that we are dealing with the required documents to privileged patient information
that is not available, not even when directed by a court, except in cases where
the patient has given consent. Zuber and Lisook steps from there with only one
paper that they handed Jacob, a two-page booklet on DMSO, namely that it is
therefore legally the bladder disease interstitial cystitis treated. Other
questions were not answered. Zuber admitted that he had no authority to
question the doctor, because the pharmaceutical law the FDA allowed "no
access to people, only to things." As Lisook Geller asked if such reports
were ever in in Jacobs possession, Geller assured investigators that he did
not, and no documents were removed from the office of the doctor, since the
warrant was issued. Then Zuber and Lisook beendten the meeting, they said they would
not believe him. Geller sued the FDA for harassment of Dr. Jacob. Jacob said
that there was no evidence of harm to the human eye by DMSO, the allegations of
hidden toxicity were false. Such a controversy with legal actions and
counter-actions often have the puzzling painkiller dimethyl surrounded. Its
reliable biological and medical applications took the substance to a drug most
discussed our time. It slumbered nearly one hundred years since its discovery;
now it had to blow up the medical scene. Surrounded by controversy, discord, of
accusations and Gegenbeschuldigungenbuchstäblich a war of words which include
everything other than the Warheit, is the loser of the medical consumer. The
advocacy for the patient does not seem to exist when it comes to the DMSO. The
concern for people has degenerated. The facts remain exactly in the balance;
The task of helping the victims of the disease and thus to make the best
decisions for them, was ignored. Healing specialists and medical bureaucrats
obviously miss their responsibilities towards the population.
^
The origin and the origin of dimethyl sulfoxide
DMSO was the first time synthesized in 1866 by the Russian
scientist Alexander Saytzeff, from Kazan, on the river Volga, in Central
Russia. He noted that the substance was colorless, had a garlic-like odor, it
felt oily to the touch, as well as petroleum looked when it was poured from the
test tube. She left an aftertaste similar to the oysters. They aroused the
curiosity of Dr.Saytzeff, and his colleagues, as dimethyl sulfoxide with almost
all chemicals Association, which he dropped into the solution. It was an
excellent solvent, useful as degreasers, paint thinners and antifreeze.
Approximately 80 years ago, was the only publication that informed the science
relating to the substance, the work of Dr. Saytzeff which he had submitted to
an obscure German chemical journal publisher who printed his article 1867th
After the Second World War chemists began thus to active interest in the
substance to be found. A number of works appeared in 1948 in the chemical
literature which showed that DMSO is a very good solvent. In 1959,
demonstrating an English-oriented research group that the solution red blood
cells and other tissues protects against freezing. Dr. H.Harry Szmant, chairman
of the chemistry department at the University of Detroit stated that the liquid
has a tremendous ability to dissolve other substances. She is a Regent, who may
be some chemical reactions to a "billion times" speed. "The
unique ability of DMSO is the penetration of living tissues without causing
significant damage, is probably related to its relatively polar nature to
accept hydrogen bonds, and it consists of a relatively small and compact
structure." He said. "This combination of properties results in the
ability of DMSO to bond with water, proteins, carbohydrates, nucleic acids,
ionic substances, and other components of living systems. Of the greatest
importance for the understanding of the possible functions of DMSO in
biological systems is its ability to replace some of the water molecules, which
are connected to the cell components, or to change the structure of the
ubiquitous water. "In 1962, the controversy began to encircle the DMSO
when Dr.Jakob the first time began to be interested how you could freeze
certain human kidney, and considered the solution for its own purposes to use.
He asked Robert Herschler, a supervisor via chemical applications in Crown
Zellerbach paper mill to some of the chemical. Crown Zellerbach could save a
lot of money, since DMSO had become a by-product of its paper production. For $
5 a quart, it could be produced in raw form to then refine for human
application. At their first meeting mentioned Robert Herschler that he would
have difficulties to wash the stain of his hands when both DMSO and color came
to the hands. Dr. Jacob recalled: "We pinselten DMSO on our skin, and 15
minutes later we noticed a oyster or garlic-like taste. The skin surface on
which there was the chemical was dry. " The drying effect of dimethyl
sulfoxide sparked a bang. The drying property of a therapeutic agent makes this
useful in the treatment of burns, as the moisture makes the feed infections.
Jacob and Herschler attempt this at burns of rats, and found that those treated
showed a calmer behavior, than the untreated plants. The drug relieved burning
pain. .sagte Dr.Jakob "From this point on, the use of DMSO spread like
wildfire" in an interview. In the USA, DMSO is recovered from the Lignim,
the substance, the structure of the trees solidifies. In Europe or other
countries it is synthesized from coal, oil or other organic substances. Joint
efforts of Jacobs staff representing the medical faculty of the University of
Oregeon and Herschler by the company Crown Zellerbach, demonstrated in
laboratory tests that DMSO not only the skin and muscle membrane penetrates,
but the penetration is in a position, a certain number other substances to be
transported. For example, one penicillin in DMSO dissolve, to transport it
anschliesend without needle through the skin. Local anesthetics can be
transported in the same way. In these early studies, the DMSO was also
introduced to relieve pain, to reduce swelling, to slow the growth of bacteria,
to improve blood circulation, aufzweichen the scar tissue, to enhance the
effectiveness of pharmaceutical agents, as a diuretic, as well as its property,
muscle to relax. It elimierte the pain of sprains, strains, arthritis, and even
the pain in broken bones.
Vets were using the substance by prescription for Arthritic
conditions or injuries of animals. Applies at the Arthritis of greyhounds
allowed either an injection of DMSO or Kortikois (a substance that has the
effect as a hormone of the adrenal cortex) take the animals back to the
competition. After 6 months, more than 60 percent of patients treated with
Kortikois dogs had a relapse in treated with DMSO dogs this occurred in less
than 20 percent.
^
The FDA enters the picture - The controversy began ...
The first report on the use of DMSO as a pharmacological
agent was written by Jacob in 1963 and published on February 1, 1964th This
caused a wild flurry of studies and enthusiasm to the new "miracle"
drugs that carried various substances through the skin, as well as in all other
organs of the body. It was soon apparent that the chemical in many cases could
alleviate Enzündung and pain, some of felling were not previously treated in a
conventional manner. The first clinical trials of investigational for DMSO on
humans were submitted on 25 October 1963 at the Food and Drug Administration
(FDA), and subsequently approved. It developed rapidly an enormous interest in
the drug, up to the point at which it was applied very intense, especially for
the treatment of sprains, bruises, and minor burns. The medicine was free and a
large number of researchers in general medicine, special medicine, and also to
specialists for Para medicine, including physical therapists, a few dentists,
nurses, and the author of this book, a formerly practicing podiatrists
(podiatrist), distributed.
Until 1965, about 100 000 patients received this treatment,
studies have been conducted, but the FDA considered this to be insufficient to
clearly demonstrate that the observed benefit of the drugs ran out. In an
editorial in the New York Times on 3rd Aprill 1965 DMSO was called the
"miracle drug, produced in the 1960s". In July 1965 international
symposium was in Berlin, West Germany, held in the medical scientists exchanged
information on the mode of action of DMSO. Nevertheless, three applications
were submitted to a new drug to the FDA in 1965, all three were rejected. The
pharmaceutical company Merck, Syntex and Gibb submitted their initial proposals
with the declaration that DMSO would be ripe to be a normative means. The FDA
rejected their declarations and their applications, and publications
tatsächtlich his own explanation in the Federal Register, which is that all
clinical applications of DMSO were set. The authority cited toxicological
studies which showed that high doses of the drug had changed the refractive
index of the eye lenses in experimental animals. What's that a change occurred
in their focusing power, and a certain clouding of the lenses is hired. The
Authority was concerned that this visual damage may also occur in people who
are exposed to the DMSO. These scientists and bureaucrats knew at this time
that the eye changes were limited to a few species. Nothing happened in
monkeys, or most importantly in humans. A year later, this prohibition policy
was eased somewhat. The FDA allowed new research on the clinical evaluation of
DMSO at serious forms of disease such as scleroderma, persistent shingles and
severe rheumatoid arthritis, for which there were no satisfactory treatment
options. In September 1968, the FDA issued another revision, relaxing its
DMSO-policy, it allowed topical application to the skin, not longer than 14
days, for less serious conditions such as acute Muskoskeletal problems- such as
sprains, bursitis, and tendonitis , This relaxation of the rules based on a
toxiklogischen study that provided a comforting result: No Evidence of
Toxisität of DMSO on the human eye could be provided. Nevertheless, in 1971 an
application for admission to the Company Gibb Pharmaceutical filed with the
declaration that DMSO has come to be prescribed in the US, in turn, rejected. A
request in 1978 provided by Research Industries Corpoation for the use of DMSO
in scleroderma. The study was designed by Arthur L.Scherbel, M.D., then chief
of rheumatology Dr Cleveland Clinic Foundation, under the supervision of
physicians and the FDA advisers of the National Academy of Sciences. Dr.
Scherbel led by this study, and observed changes in a treated hand, compared
with the untreated. In three months, a significant improvement ceased, which
was statistically significant. As Dr.Scherbel to the FDA approached to
recognize his study, this was disappointed. The new application has been
rejected. Until 1983, rejected by the FDA new applications included 1500
medical studies, carried out at about 120 000 patients with a variety of health
problems. In addition, four symposia were held by the public health community to
get more information about the DMSO. The second symposium, held in New York
City in March 1966 was among the Auspizen the New York Academy of Sciences. The
third was held in November 1966 by the University of Vienna. The fourth and
fifth place again in New York, in January 1974, and in September 1982 under the
sponsorship of the New York Academy of Sciences. In all of these symposia was
reported positively on the medicine. Due to ongoing difficulties between DMSO
pioneers and medical bureaucrats, asked in 1972, Carles C. Edwards, M.D., then
the Commissioner for drugs, the national Academy of Sciences to review all
information available on the effectiveness and toxicity of DMSO. He wanted the
members of the National University of FDA provides an independent opinion on
these matters.
The Academy appointed a committee of experts to carry out
with six subcommittees to the assessments. The Committee conducted an active
assessment to 1974th At the Academy, it was, however, a parastatal organization
that was not truly independent. Since the Academy was funded through a
FDAVertrag, they tended to share the settings of the FDA via the DMSO. The
final report was that the evidence of the effectiveness of Arzeimittels to
treat disease was insufficient, and that the Toxic Potiental was large, so that
the drug should remain a medicine for research.
In addition, further controlled clinical research would be
needed to prove the effectiveness of DMSO.
Since no evidence of damage to the human eye by DMSO
templates FDA regulations against the agents decided repealed. So, finally, on
21 September 1979, the Authority revoked the Restriktierung public. Only Jere
Goyan, former head of the entire FDA, went on to express political statements
about the dangers of Augentoxicität. He sent statements to investigators that
were not justified to collect reports on the relation of DMSO on the human eye.
In 1983, the FDA had present 16 new applications for admission. The studies
included diseases such as scleroderma, joint injury, and spinal cord injuries.
There were no applications for renewal of the studies on the application of
DMSO for treating rheumatoid arthritis, osteoarthritis and what appeared
ungewöhnich because the application of DMSO in these complaints on Popular is.
^
The public rebelled against the FDA Restriktierungen
The public rebelled against the FDA Restriktierungen
Despite the Restriktierung the application of DMSO by the
FDA, there have tens of thousands of US citizens already managed to get this.
Some applications in the form of a drug had already been approved for
veterinary use. Some got it as an industrial solvent, others traveled to
special DMSO arthritis clinics to Mexico. The drug was passed from person to
person, especially among victims of arthritis. So far, there is no application
for authorization which is present to the FDA, although osteoarthritis and
rheumatoid arthritis by DMSO can be treated even by laymen. The public rebelled
against the imposition of nonsensical regulations that restrict the use of
DMSO. People wondered: "if the agent is sufficiently safe for the Internal
use in interstitial cystitis, why should it not be safe enough to it to remove
skin in arthritic conditions on them" A black market has developed to the
supply of the substance. Pharmacies sold DMSO in medical grade on prescription
of a doctor for about 15-20 dollars per 125 ml Actually it is not illegal for a
drug once get an approval by the FDA for safe applications -. As in this case
for interstitial cystitis - for a doctor to prescribe it for other purposes.
The thriving national trafficking of DMSO was also unfortunately run over the
counters of hardware stores, gas stations, shipping worldwide, from the loading
areas of trucks, near shopping malls and parking lots, and even ice cream bars.
For example, reported the Chicago Tribune Magazine in an article published by
her article that technical sulfoxide, appeared in so unsightly places such as
ice cream bars or locksmith shops. A specialized trade for solvent based in
Seattle, Washington sent a free mail-order number, and opened offices in
Milwaukee, Chicago, and Evaston, Illinois. The sales pitch was to make no
medical claims about the DMSO. "We sell it as a solvent, what you do with
it is your business. Any other use is illegal ", said the sales staff.
Billy Williams, the general manager of a company dealing with solvents, assured
that the DMSO, which he sells, would have pharmaceutical quality. It would be
safe, he promised the people he sell it only for tactical reasons as solvent. "We
market the substance because it sells," said Williams. "We suspect
that people apply it. We get orders from doctors, chiropractors, and dentists.
"He opened a plant for packaging and distribution ses solvent, bought
pharmaceutically pure DMSO in low in chemical labs, whose identity he kept
secret, and packaged it then in smaller bottles in its facility in Seattle.
"We buy it third-hand from a medical lab." Continued Williams
continued, "they give it to us through the back door." "Regarding
the medical application, we can not help, however, we are aware that it applied
by the people currently is to alleviate the pain in Arhritis. I have read many
letters in which was that people apply it if they believe they have arthritis,
muscle strain, or other medical disorders. "" I can tell you why we
sell it, we sell it for profit. This may sound crass, but that's the real
reason why people make transactions. This stuff works! We do not intend to make
at the Miserie of another. "Another typical source for public sale was a
hairstyling salon in Chicago. The manager of the salon said, he put the sale of
the solvent, because of the controversy over the legality. "I sold it only
a few days," he said. He bought a package with technical DMSO by a police
officer from Chicago, who had supplied the ice cream bars to the middle. The
company Research Laboratories, INC, in Salt Lake City, Utah, is often called by
the FDA as a source of dimethyl sulfoxide, if requests by physicians or other
healthcare received that wanted to use the substance for therapeutic purposes
in humans. The company Research Laboratories sells a 50 milliliter (ml) vial
DMSO, that is suitable for injection, for $ 28. to acquire the best source for
the consumer, DMSO is Dr. James Critchlow, owner of the company American
Pharmzeutic Enterprises, Inc, PO Box 12543, Scottsdale, Arizona 85267, Tel.Nr:
(602) 998-412, or the toll free number (800 ) 345-3391. American Pharmazeutic
Industries offers desodiertes pharmaceutical DMSO, which is entirely suitable
for therapeutic use in humans. A pint for Mail Order $ 60 and Dr. Critchlow`s
slightly lemony smelling DMSO cream per 120 ml glass $ 29.95. He adds doctors
Oteopathen, Podiatrists, Naturopaths, Homeopathen, dentists, nurses, physical
therapists, and other members of the health care, use of DMSO as part of their
therapeutic resources. Under the company name Critchlow, Phyne Pharmaceuticals,
Inc, PO Box 12543, Scottsdale, Arizona 85260, Tel.Nr .: (602) 998-4142, for
free: (0800) 3453391, DMSO products medizizinischem purity for Topical or
interior application are offered. The DMSO solution the company Phyne
Pharmakeutical is so pure that it use many doctors intravenous infusion to the
patient. The product prices are lower still when bought in larger quantities.
Federal studies to former FDA Commissioner Jere E.Goyan matches, indicate that
technical DMSO is not suitable to werden.Es applied on people does not go
through the same quality control, as the medical. When the solvent is decanted
into smaller units, there is the possibility of contamination. The FDA stated
in an official warning that "the risk that the application of technical
DMSO accompanied ...... is its ability as a transporter to bring harmful
substances in the bloodstream, if this in not sterile DMSO or on the skin
surface are. "" the people taking a risk if they use a substance of
unknown quality or effectiveness. "said Commissioner Goyan continued"
It is a risky thing to drink a substance injected, or applied to the skin, not
for this purpose is determined. "the black market, whether with technical
or medical grade, continued to flourish, as the FDA gave the drug for any other
use of the market, as for the treatment of interstitial cystitis. Arthur
Scherbel, former senior physician at the Department of rheumatic diseases and
immunology explained that the FDA restrains' authorization for the medicinal
product for not reasonable. People use the DMSO without professional guidance,
and that would be wrong. The sooner it is allowed, the better. "
^
The legislator acts on behalf of the people
No less than six Resulutionen were introduced in the US
Congress to the general use of DMSO to legalize, and to disregard the
instructions of the FDA. US Senator Mark O. Hatfield brought that: "As
long as me there is no scientific expertise, I am unable to issue an absolute
statement that the DMSO the wonder drug of the century appears to be, but every
little part of evidence, the I found, reinforced the premise that it is so.
After 1200 published studies on the merit of DMSO that it is safe and
effective, according to international symposia in Germany, America, and
Austria, after three different pharmaceutical companies have submitted an
application for renewal of a drug to the FDA, DMSO is so far not available for
the American people, even though it is available in many other countries. I
have urged the Senate to support my legislature, on behalf of all Americans who
today suffer from diseases that are untreatable with any other known substance,
and their not needing the drug in the future. "The Honorable Wendell Wyatt
brought the legislation to get into the United State House of Representatives,
a, with the aim of a fair hearing on the DMSO again. "Since the FDA is
going on flimsy evidence against DMSO," as Wyatt, "we were not able only
once this issue to our attention. The whole thing had disappeared behind a
bureaucratic cloud. "The efforts of Congressman, and other members of the
US legislature paid off. On July 31, 1980 Senator Edward M. Kennedy held a
hearing of the subcommittee of the Senate on the importance of the drug from
the FDA. On March 24, 1980 Congressman Pepper chaired a hearing (under the
title "DMSO; a new hope for arthritis) before Congress Committee on Aging.
Because of all these hearings the Inspector General of the Department of Health
and Human Rights sought an investigation into the regulatory process, the DMSO
was subject to the FDA. In addition, some diets have changed the FDA
regulations on the DMSO levy, the laws were changed so that they allowed its
use by authorized health care workers. There currently allow 8 states,
including Texas, Washington, Montana, Florida, Oregon, Louisiana, and Nevada
prescribing the drug. The legalization of DMSO in Florida is another example
about the rebellion of the people against the FDAVorschriften. The difference
here was that the legalization of DMSO has been driven by a Legislator, whose
wife was forced to travel because of DMSO treatments to Mexico. In 1977 the
drug in Florida for intramuscular, oral, and topical therapy in humans
legalized. In the law of Florida could read as follows:
Part 1.
No hospital or other health facility should interfere with
the doctor-patient relationship, by Restriktieren or prohibiting the use of
dimethyl sulfoxide, as long as it is prescribed or administered by a physician
who is licensed pursuant to Chapters 458 and 459 of the Statutes of Florida
when it requires the patient, whether denn' that the substance was prescribed
or administered by a physician, is found to be harmful by the public authorities
of the medical examiner, and osteopathic medical examiner at a hearing
conducted pursuant to the provisions of the administrative procedures Act,
Chapter 120 of the Florida statutes. Furthermore, no hospital or other
healthcare facility may revoke a physician personal privileges after the said
doctor solely sulfoxide has prescribed or administered to a patient under
conditions that continue in this Act.
Section 2 below.
No physician who is licensed pursuant to Chapters 458, or
459 of the Statutes of Florida may the subject of disciplinary action by the
authorities of the medical Respectively are osteopathic examiners, because of
the prescription or administration of dimethyl sulfoxide to a patient under his
care, who asked for the substance.
Section. 3
The patient, having been informed thoroughly by the doctor
about alternative treatments, and the potential of the treatment, and was also
discussed issues concerning the administration of dimethyl sulfoxide, to sign a
written release that the doctor, the hospital, or the health facility from any
liability represents.
Section. 4
Section. 4
The physician must inform the patient in writing that
dimethyl sulfoxide (DMSO) is not approved by the FDA for the treatment or cure
for the cure of medical conditions for which it was prescribed.
Section. 5
This law should not be applied in diseases of the dimethyl
sulfoxide (DMSO) has been approved as a treatment by the FDA. Following the
passage of the new law, the potential was abusing this, inspired by paid
listings of DMSO clinics as well as by the wide media coverage, the Florida
Medical Assiciation (FMA) was prompted in 1980, a statement to all the
newspapers of Florida, publish in the form of a letter to the editor. A 60
minute television program caused an almost daily onslaught of written and
telephone inquiries to the headquarters of the FMA in Jacksonville, Florida.
Most national anfagen came from the press, who came out most state of people,
with diverse symptoms that were looking for a doctor who could provide them
with the "miracle cure", called DMSO.
The official position of the FMA was:
Without another authorization the medicine in Florida may
not be marketed and distributed, except for the treatment of bladder disease.
Anyway, it would be legal if a doctor would prescribe an approved drug for other
indications. The Legislature Florida managed in 1978 a law that allows a
doctor, DMSO should be applied where this had informed the patient about
alternatives for treatment, as well as any potential of cure. The law requires
that the patient has to sign at the request of the doctor a written exemption
declaration to the doctor, hospital or institution. The doctor has to inform
the patient about when DMSO is approved for the disease, which was described in
the Statement. The FMA did not allow it to escape from the proven and
responsible mechanism for the introduction of a new drug. In fact, were doctors
who were insured against liability over them, warned in relation to the drug.
They would lose their insurance coverage when they would apply DMSO, with any
other symptom, as the bladder disease, for which the agent, as previously
reported, was approved by the FDA. At the same time the FMA encouraged his
doctors-members who showed interest to participate in a research program. It
was about a new test preparation, which they had received from the FDA, a
sterile nichtpyogenen DMSO solution. To participate in this research, the
doctors had to agree to in order to perform the necessary documentation. The
DMSO solution would be supplied free of charge, and would
doctors given support to produce the necessary protocols. As
in the legislature diesjägrigen the law on the manufacture, distribution, and
sale of a DMSO ointment in Florida was adopted, the FMA had no great sympathy
with the course of this thing. I was an employee of the Department of Health
and Rehabilitation Services (DHRS) informed that they are going to design
regulations to nationalize the production of such a product, and that therefore
a formal application is received. These Regelungenkönnten also employ an
Attorney General, which it previously did not care if it was allowed to prepare
DMSO in Florida. The inquiries from consumers concerning the DMSO, or other
experimental drug should be addressed to the FDA, in Maryland. Doctors who
would be interested in the experimental drug program also mitzuarbeitensollten
contact in Maryland the FDA.
On January 28, the public Gesundheitskommitee the State of
Connecticut 1981hielt from a committee meeting in which it was whether the
state should encourage doctors to treat painful and deadly diseases with DMSO.
With the bill of Wolocott freed the Representant of the state Connecuit, Eugene
Migliaro, doctors of their persöhnlicher liability if they prescribe DMSO.
Migilaro explained that the public should have the DMSO by the Post. "We
know that DMSO is not a cure," said Migliaro. "And I know the things
that can pass through it, if it wrong to apply it incorrectly. I mean to say
that doctors are supposed to protect the people without being sued there. The
deputy chairman of the public Gesundheitskommittees, Senator Regina Smith,
noted that doctors are also for all other drugs they prescribe, liable. She
pointed out that it would set a dangerous precedent by would take them from
liability in this experimental drug. The bill of Connecticut had thus failed,
but the DMSO proponents indicated that they intend to submit a new draft
outdated. They did not. Basically, I agree with Senator Smith, but the FMA now
fell from one extreme to another. Florida medical labile policy will actually
allow the use of DMSO for nothing else than for bladder disease. In the time
that the FMA issued its official statement and the State Legislature of
Connecticut to the bill put forward to bring doctors off the hook, for the
event that something went wrong with a patient to whom they had the DMSO
prescribed woke up the state of Florida. James T. Howell, an official of the
Department of Health and Rehabilitative Services, it considered important to
give on the subject DMSO his comment. In the press he expressed his deep
concern over the fact that a technical type of solvent of DMSO was offered for
human consumption, which would be extremely detrimental. Two television shows
with enormous viewing figures were transmitted by CBS-TV; the one in March 1980,
and the repetition In July 1980, would have brought the people to throw all
caution to the winds. The public insisted on getting the analgesic drug in the
hands, whether it was surrounded by controversy, or not. Everything what people
want, was the relief of pain, regardless of their origin they were.
Interestingly, undergo various prominent personalities from sports, politics
and other areas of DMSO treatment without concern about whether its use is
legal according to the judgments and standards of the FDA. The various
applications of DMSO in clinical use and for home, have been used for
self-treatment of ailments such as arthritis, shingles, headaches, cataracts,
herpes simplex, Down syndrome, spinal injuries, bursitis, contusions. The
different types of treatment, if applied to the skin, intravenous therapy, as
well as oral or intramuscular therapy were required from all desperate, whether
they were famous or not boasting.
^
The new painkillers gained media fame
As the governor George Wallace traveled through the country
to carry the DMSO, administered by Dr.Jacob Stanley to experience pain relief,
this new drug schmerztötende got a big boost. He started treatment on July 1,
1980, to relieve the symptoms that accompanied with paralysis. Wallace was confined
to a wheelchair, as in 1972 he was wounded in an attempted assassination, in
his campaign for Presidency, in Laurel, Maryland. The doctors diagnosed that
Wallace's complaints in the "flank" occur, a medical term with the
area between the lowest rib and the Tallie is meant. As his pain was not
excruciating, were Wallace's daily activities only cumbersome and were
concentrated. The complaints of the edge of the governor were reportedly
disappeared result, especially after faithfully spotted from time to time DMSO
on the painful area in the course of a month. Since this was a well-known
public figure in Wallace, had his success, to alleviate his pain impact on the
rise of DMSO to a painkilling or anti-inflammatory drug which also worked. To a
much greater thrust contributed the television news, was shown where that
Wallace DMSO regarded as the definitive and controversial product to eliminate
pain, in the event that all else failed. Wallace warfrüher divided against, and
he knew about the inadequacy of this situation. The TV show animated the
governor to try treatment with DMSO. On May 23, 1980 and again on July 6, 1980
it was reported in a popular television program 60 minutes on DMSO. In a part
of the consignment, which was provided with the title "the riddle of
DMSO", the TV correspondent Mike Wallace drew wide international attention
to this chemical. In the broadcast Dr. Richard Crout, the head of the FDA, and
an opponent of DMSO said that Dpoppelblindstudien were mandatory prior to
approval by its authority. Until now, researchers were not to conduct
double-blind studies because of the smell of the product in the situation.
Within 5 minutes after it has been applied to the skin, you can taste it on
your tongue; It penetrates the skin and flows just as effective through the
bloodstream. There would be a lot more about the matter DMSO to report,
however, during the 60 minutes Mice Wallace agreed to the human factor, in
which the relief of pain plays biggest role. He showed Emily Rudich who played
despite their severely deformed fingers and years of burning through the
unerbittelichen pain of arthritis on the piano.
To the DMSO effect on their previous state Mrs.Rudich said
the following: "I had very bad by the arthritis, gnarled fingers, the DMSO
relieved the arthritis on the spot. There is no magic bullet, in curing the
disease from not really, but it relieves immensely ....... I had fever blisters
on my lips. Then I turned DMSO three times, and the cold sore immediately
disappeared. Also, I have often times cut me in the kitchen, and sometimes
really bad, after application of DMSO the cuts began on the site heal. On most
dramatic was the case of Sandy Sherrick, of Riverside, California, who suffered
from various stinging pain and nerve damage, which they drew upon a car
accident two years ago. In November 1979, Mrs. Sherrik doubled by the presence
of the back and shoulder pain headpiece. "To help seemed no therapy, not a
doctor, not a pain reliever." Said Mike Wallace. "Oh, this pain was
extremely bad," confirmed Sandy Sherrick. "It was the point at which
I cried last. I cooked no food, I no longer cleaned. I could hardly put
yourself ....... Finally, the doctors came to a point where they simply told me
that would affect the conditions me, and that "I just had to live with
it." As Mrs. Sherrick from DMSO erfur, she thought it was their last
resort. Under terrible pain she flew to Portland, Oregon to be treated by
Dr.Jacob. After the third intravenous and topical application of DMSO, started
the patient to be a little better feel, Mike Wallace reported. He followed
their progress for 60 minutes, which were documented on videotape. Before them
home again traveled told her Dr.Jacob topical application of DMSO on her neck
and back.
Then the television camera panned in the home of Mrs.
Sherrick, in Riverside, California. She felt good, laughed, and took no
medicine for pain relief more. She said, "Oh, the pain has gone away. He
is completely gone from my neck .......... I tell the Warheit, I swear to God.
You could make your household, drive a car, and lift packages. "I have not
found anything that I could not do that." She continued. Mike Wallce noted
that the history of Sandy Sherrick is not comparable to the medical tests that
urges the FDA. "Well, that's nice. I can understand their opinion.
"Said Mrs.Sherrick." But they should be able to consider these test
results, and take me as an example. I ware independent to determine whether the
agent or not working. All I can say is what it has done for me personally. It worked
for me. "This strong representation reached 70 million viewers. Dr. Jacob
practice was at once flooded with more than 10 000 people who shouted
figuratively: "save me, save me from my pain." Pain victims also went
to other doctors in the US, Canada, and Mexico, which were known, that they
would use DMSO. They came in droves. The phones in the practices of doctors, as
well as pharmacists no longer stood still for days after the 60 minute
television program on Sunday evening had been aired. Subsequently, it was a
telegram refusing the FDA to allow the drug, printed across the country in the
Tuesday editions of newspapers. In the note to his mission Mike Wallace
declared: "Tomorrow the Kongressauschuss in Washington starts early with
an investigation to determine why the DMSO is not available for all Americans,
miteinbegriffen for any appropriate application ability, pain, and slight
pain." The number of letters and calls that arrived at the offices of the
Congress, and resulted from the unavailability of DMSO, was massive. Some
sample letters as they were sent to Congressman Claude Pepper, are in chapter
4. The disclosures came during the examination by the Congress were to light,
shocking, for already be located at a loss medical community. The apparatus
with which the FDA investigated the effectiveness of new drugs was twisted. As
it is discussed extensively in Chapter 13, led the revelations about the
ignorance of the medical methods and schwindlerische tests in relation to the
effectiveness of the drug not only in DMSO opponents to stop their clinical
trials, but even to the withdrawal of their views. This blocking of therapeutic
product properties of DMSO also affected the main proponents of the agent,
namely Dr.Stanely Jacob. As you can read in more detail later, the FDA took
investigators Dr.K.C. Pani allegedly money from Dr.Jacob contrary, in order to
pay the very high bills for cancer treatment of his wife. Dr. Pani thereby lost
his reputation, and his Abeitsplatz with the FDA. Dr. Jaob was indicted by the
Federal Grand Jury to have played in three cases improper payments to an FDA
employee, as well as in a case of criminal conspiracy. In May 1982, was carried
out because of the matter of the process. In response, the government examined
again with Rr.Pani and Dr.Jacob.Dieses time haggled Dr.Pani in his plea, and
accepted a conviction. Dr Jacob was not only acquitted, the FDA gave him on 29
October 1982, an excuse for their incorrect harassing the pioneering surgeon.
Moreover, when Congress discovered that poor and schwindlerische techniques
were used in the studies to the DMSO, for bladder disease, the only disease for
which it is approved in the US, the FDA should have revoked almost this
approval. Neither this, nor any other internal or external application should
not have been allowed in the United States for approval of DMSO. The company
Research Indistries Corporation (RIC), the manufacturer of Rimso-50, the most
widely sold brand, based on DMSO, apparently played a large role, the breach of
trust of the FDA with the drug. In a semi-confession, the president of the RIC,
the Senator Edward Kennedy, the complicity of his company to the mismanagement
in clinical studies of the bladder disease admitted against a. And there was
still more unpleasant discoveries that will be revealed at the end of my book.
Anyway, the whole precipitate from the investigations of the Congress was
created by human weakness, greed, both unzutreffendem behavior, and not from
the physical, chemical, or biological defects of dimethyl sulfoxide. The drug
remains as effective as ever-a true natural remedies that this carries on to
surprise holistic and conventional scientists, as a new and powerful healing
principle. Ultimately, the result of the uncovering of the sandal 10 years ago
that very few studies on the DMSO carried out and published since the period
1982-83. Compared with previous decades, have a few magazine might emphasize
relatively 100 of all that cited by these pages were-extensive work on
sichgenommen, the medical faculty of the University of Oregon. When the DMSO
would experience a recurrence of interest by researchers, would happen more by
the medical consumers who read the Artilkel in magazines, or such a book as
this, awaken the medical profession. Because of the dramatic healing
properties, dimethyl deserves a more respectful attention than merely public
interest. Science must take up the challenge. The public should have access to
the remarkable therapeutic principle of DMSO, about which I will report in the
next chapter.
^
Chapter 3
Chapter 3
The therapeutic principle of DMSO
A married couple met in Sarasota, Florida, directly after
the 60 minute television program. They drove through the night, coming from
Hamilton, Ohio, since they had an emergency appointment at 9am with the Douglas
Center for Preventive Medicine Nutrion and (already closed) to obtain a new
miracle drug for pain management. They felt their search for the DMSO as a last
attempt by the, for a whole year ongoing and $ 10,000 expensive, unsuccessful
treatments by other conceivable methods. Mrs. Dabbelt explained that the left
hand of her husband had become stiff, and claw-like, after the intervention of
the surgeon to remove a blood clot in his arm. The hand was useless. Nothing
helped, so that the muscles regenerated to its normal capacity, and after a
series of unsuccessful attempts, indicated to doctors that the problem would
psychiologischer nature. After three intravenous injections of DMSO, was Fred
Dabbelt able to open his hand and close command something he had previously
thought impossible. In total, the patient was treated for five days. When he
was contacted nine months later, he said: "The pain is completely gone,
though my hand is still numb, but usable. Before DMSO saw the hand like a claw;
now it is normal. "" We tried everything. That was our last chance.
"Said Mrs.Dabbelt. "It is simply amazing. Before this matter, nothing
worked. "How does dimethylsulfide actually? This can best be taken in the
words of Dr.Stanley W.Jacob, a co-discoverer of the therapeutic properties of
the drug. "We have barely scratched the surface, for it is considered a
new principle in medicine. In our century, there were only three new antibiotic
of principles the principle that cortisone principle, and now the DMSO Prinzip.
and the DMSO principle is the only new to our generation. All controversies
left aside, my view is that this history is written.
This chapter explains the modus operandi of DMSO and
discussed his Pentrationsleistung (penetrating power), as well as the ideas for
its use. We will use the highest specialist, biochemical science, and to
simplify this as much as possible without changing the hypotheses on which to
base the operations of DMSO. Students of biophysics and biochemistry are the
following information deemed to be useful. Others want weiterblätten on page 44
for summary.
^
The structure and the physical properties of the molecule
The Dimethylsulfoxidmolekül is ten-sided, with a center that
is occupied by a sulfur atom. Two methyl groups, an oxygen atom, and a
nonbonding electron pair are located at the points of the tetrahedron. Explore
the Figure 3.1. to illustrate to the molecular formula. The molecular weight of
DMSO is 78.15. The drug is undergoing a chemical reaction in a position which
is accompanied by the generation of heat, and the loss of 60 calories per gram
DMSO, when mixed with water. The boiling point at 760 mm of mercury, is 189.0
degrees Celsius; specific gravity at 25 degrees Celsius is 1.0958 g / ml, the
solidification point is 18:55 degrees Celsius, the combustion energy is 6050
cal / g, the flash point in an open vessel is 95 degrees Celsius, the viscosity
at 20 degrees, the surface tension at 20 46.2 degrees. Since the freezing point
of DMSO is 68 degrees Fahrenheit, it is to bring in a position whose
approximate concentration in experience, having for example a bottle of solvent
was purchased from an unknown source. Enter the unopened bottle easily in the
refrigerator (not the freezer). Within two hours, the liquid is determined,
like ice. You now have 99.5 owned DMSO, the purest and most highly
concentrated, which can be produced. If you leave the stopper on the bottle,
which prevents the hydraulic neutralization, (decomposition), so that the
liquid freezes at 68 degrees Fahrenheit or less.
Figure 3.1 molecular formula of dimethyl sulfoxide
If, after the bottle was turned upside down, run small
asserrinnsale through the ice, you have possibly bought the veterinarily
specified DMSO. This has a concentration of 90 percent. The remaining 10
percent is distilled water. Should not freeze the DMSO when it is in the
refrigerator, you enter it in the freezer. Should not be hard, even though it
was cooled below 32 degrees Fahrenheit, this may indicate a 50 owned DMSO-water
mixture. Should it be hard in the freezer, so it is in the liquid not to DMSO,
or there is everything from water, mixed with a small amount of solvent. 50
owned DMSO is an antifreeze, it would work well in cars for winter driving. To
liquefy the DMSO, which has transformed into a block of ice in the bottle, just
specify it in a pan of warm water. In pure form, the life of the solvent is
unlimited. The DMSO can be used for years. Many other physical properties of
DMSO could be explained, but those who have been given here, offer enough of a
symbolic taste, because it is not only is a text about the chemical and
physical properties of the solvent. Almost all chemical and physical properties
of DMSO can be found in the technical notice of dimethyl sulfoxide, which was published
by the paper mill Crown Zellerbach. The crystalline structure of this solvent
suggesting the weak presence of a hydrogen compound that contributes to the
strength of the molecular DMSO. In the liquid state, DMSO seems to assume a
chain structure, held together by the alignment of the two sulfur-oxygen pole.
From this structure, it was believed that she, a partials
decline experienced between 40 and 60 degrees when various properties of the
solution, such as the refractive index, the viscosity, significant changes
have, in their temperature coefficient as well as in this temperature range.
Chemists have found that the ability of DMSO to bond with molecules that have a
thick layer of hydrogen ions, and with neutral molecules, as well as with ionic
species is a fascinating property. It makes DMSO at an excellent solvent, and a
penetrant which penetrates organic and some inorganic materials. Interactions
between the DMSO and other substances may be the proportion of the
polarizability of the other substance to rise. The solubility of the substance
in DMSO is promoted not only by the nature of molecular interaction, but also
favored to the degree to which the energy of a system or substance is available
to function. The greater the density of the spherical molecules in which is the
"free volume" of the liquid DMSO, the better the solubility of the
cyclic, unsaturated hydrocarbons, as compared with unzyklischen saturated
hydrocarbons. The solubility of a substance increases with the decrease in Elektronengavivität
of atoms forming the when the solvent is mixed. DMSO has a strong hydrogen
compound with hydroxyl groups. The properties of DMSO, as the snapping of
hydroxyls radicals is the reason that this chemical ion at Arhritis sets the
tone. Hydroxyls radicals are responsible for the decomposition of the synovial
fluid and the cartilage of the joints. As one of the few known substances,
which is responsible for detoxifying the Radical, the DMSO forms through the
hydroxyls ion, dimethyl sulfide and water. These are easily excreted from the
body. The neutralization of this highly toxic free radicals caused the
reduction of inflammation, as well as the decline in pain in arthritis. It may
be the primary mechanism, effectively going on with the DMSO for arthritis. Incidentally
affects the DMSO on a similar therapeutic way against the pathologist
biochemical changes in cancer, atherosclerosis, and any other number of
circumstances exists in the predominance of a generation of free radicals. If
superoxide anions are present in a quantity, as a result of environmental
change, as with radioactive radiation, water pollution, chemotherapy or
anderweitigenfaktoren detoxification capacity of the body is required. The
result is superoxide, and the superoxide dismutase forms hydrogen peroxide.
Lipid peroxidation takes place. More hydroxyls radicals develop, cause the cell
damage associated with degenerierbaren diseases. DMSO compensates for these
effects, and brings the body back to a normal status. The pathology of free
radicals is a complicated part of almost every methabolischen dysfunction that
has ever been known. In order to illustrate it, cancer creates tremendous
amounts of hydrogen peroxide, then generate the free radical. This is possibly
part of the reason why DMSO was found to be nützli ch to use it in cancer
treatment. Integrative doctors use it throughout the country secretly for this
purpose. There is no "magic bullet", but in the completely metabolic
program against cancer, DMSO is simply applied as an additive. DMSO equally has
an effect on proteins or nucleic acids. It has excellent solvent properties for
dyes, starch and cellulose, and their derivatives, lignin, vinyl polymers and
copolymers, polyvinyl acetates, Halogeniede, and other substances, which would
be to Extensively, those enumerate in this volatile description of its
pharmacological effects. Sublime as water, into compounds which are based on
the induction of two poles in aromatic'Ringen, DMSO, the side with the
"bound" water molecules in relatively motionless protein structures
is able to convert. It has the unique property to transfer through the skin
barrier, without significant tissue damage. There seems to be a loose protein
structure formed by the replacement of water in the skin. At a presentation in
a conference, held at the half-yearly meeting of the American College of
Medicine, in May 1980. Dr.Jakob said: "The DMSO is literally the modified
ego of water. It moves through the membrane, and is a substitute for water, so
it attracts substances by cells that do not really want to move through it
themselves. That is its fundamental mechanism of action. A DMSO-water
connection is 1.3 times more solid than water-water connection. "This
property, that it is better combines with water than water molecules is able to
each other, is highly significant. This is probably the one that the DMSO is a
completely different type of healing effect, something that medical science has
hitherto been known.
^
The healing power of DMSO
The healing power of DMSO
In 1967 the New York Academy of Sciences sponsored a
conference on the forms of water in biological systems, and changes in its
structure by the presence of various solutions, such as DMSO. Participants of
Konverenz were very concerned about the biological effects of the different
states of water. The DMSO stabilized in water eisförmigen bundles. It is
probably able to shift the balance between less and more structured water, to
the advantage of the latter. The chemist, Dr. H. Harry Szmant said this:
"Especially since it is not inevitably the same states of water during
hydration of cell components and the usual type of water, in general, from
which it follows that the DMSO an indirect effect on biolgische systems, by
virtue of the changes exerts that it causes in the liquid structure of water.
For these more important biological consequences, caused by the indirect effect
of DMSO, one can mention the changes in the conformations and the compounds of
proteins and other molecules. Several direct to DMSO-based biological effects
without a profound change of its chemical identity, changes in the ion-pairing
balance would, as well as to the specific solvation or the donor of hydrogen
bonds influence
"Said company. Soon, informed us Dr.Szmant with that
the original therapeutic principle of DMSO is because cellular damage can be
restored-the cell can be geheit or restored almost to normal state by changing
the structure of water inside of the cell. The permeability of cell membranes
by DMSO changed into even what normally in the cell or coming out of her. As
unique nutritional substance, DMSO tends to cause the development of white
blood cells, and the safe production of migration inhibitory factor by
macrophages. White blood cells surround any foreign particles in the blood to
aid the body in fighting infections. Macrophages are large, migratory, white
blood cells, the foreign proteins, including micro-organisms, as well as other
cells, eat in the blood and in the tissue or destroy. In this way, the immune
system is made more effective by DMSO, by allowing the macrophages, to move
faster in and around the tissue. The MIF, or the factor of emigration, from
where they are needed, prevents the macrophage is immobilized and activated
spectators - macrophages. These activated macrophages have specific and
nonspecific destructive properties against bacteria, and are toxic to tumor
cells. The MIF is a kind of natural cancer chemotherapy, which is always
present in the body. Through its ability to modulate lymphocyte white blood
cells, DMSO potentiates the safe production of MIF. In connection with
immunizing stimulation, the DMSO to penetrate into the cell to prepare the
subzelluaren mechanism which is involved in the production or the release of
MIF. So to speak, it produces a cofactor that enhances the activity of MIF.
DMSO reduces allergic reactions by opening Zellmenbrane, and in that it makes
more cell receptors available for attachment of specific antigens, the
substances that stimulates the body's production of antibodies. If antigens
appear in the blood or tissue contact antibodies that are produced, or are
already in the blood against this in action to neutralize them. This process
helps to produce immunity against infectious diseases, and to prevent the
growth of malignancies. The modulating effect of DMSO on lymphocytes tends to
increase the production of other lymphokines (stimulators the circulation of
Lymphien through the vessels), such as interferon, and lymphotoxin, as well as
to improve the direct toxic effect of dilution of sensitive lymphocytes. This
dilution effect reduces the potential of a poison. This activity is used in the
control of mikrobakteriologischen infections and tumors that would be able to
break through the resistance of the body, accompanied by cancer, and can also
affect the resistance, which is related to the acceptance of organ transplant
Plata tions. DMSO could possibly either be used for cancer screening, or as an
agent that helps prevent organ rejection after transplantation. DMSO tends to
potentiate the cell's own immunity, the disease reported, as well as the
decrease of cell-specific responses, such as multiple sclerosis, systemic
lupus, rheumatoid arthritis, Scarcoidosis, lymphomatische Thyreoriditis,
colitis, leprosy, cancer and congenital diseases, with T cells defect or
malfunction. With all these problems DMSO could be quite effective in curing,
as well as useful in their metabolic treatment. Furthermore, DMSO may also
increase mediated by cellular immunity, which should be considered in autoimmune
diseases. All this potential type of DMSO is based on its ability to influence
cell membranes. It is a true, therapeutic principle, of which the full
potential has yet to be explored. Medical scientists and Biochemical monitoring
have begun difficult to penetrate the metabolic secret of this new healing
power. In a paper that was published on the usefulness of DMSO in the treatment
of headaches, Dr.Jacob wrote: "DMSO crosses willingly all membrane located
in the body, so far as is wanted, without apparently destroying the integrity
of the membrane, and allowed the passage of a number of compounds through the
membrane barriers. This mechanism has not yet been understood ....
dimethylsulfoxide blocked in laboratory testing the conductivity of an isolated
nerve, when a concentration of 25 percent was used. The conductivity returned
after the DMSO was washed away from the fiber. This blockade could be an
osmotic effect. "Nerve block is the way to work on the local anesthetics,
and illustrates why DMSO pain away. DMSO represents a new therapeutic
principle, it is not a drug in the proper sense. Dr.Jacob then share the
Kongressauschuss for aging with the following: "The difference between a
therapeutic principle and a drug is that the drug is useful one to handle ten,
or even one hundred diseases. A therapeutic principle is a completely new view
on the treatment of diseases. "At the end of 1991, the medical literature
around the world was enriched with more than 3,000 scientific studies, in which
about 500 000. clinical patients were included in this new therapeutic
principle, discharged through the main university centers, and published in
prestigious medical journals, in USA, Russia, Germany, Japan, England,
Scandinavia, Switzerland, Chile, Argentina, and many other countries in Asia,
Europe, South America, and North America.
^
Non Technical Summary of the molecular properties
Leaving aside the physical and chemical properties of DMSO
molecule thus we translate what we know into easily understandable language, here
a non-technical summary:
DMSO is a simple, small molecule chemical, with really
amazing chemical, biological, and physical characteristics.
Eine of interesting features with which users should be
familiar is the "exothermic reaction". If DMSO is diluted with water,
heat is generated.
Die bottle that contains the medicine will feel warm to
the touch. This is a harmless, temporary reaction.
Hydroxylradikale are ubiquitous and highly harmful to
health.
DMSO connects to them in order to neutralize so, this
small, dangerous time bombs that can literally blow your individual cells in
the air. The DMSO is combined with the hydroxyl radicals, adds water, then the
kidneys excrete this chemical complex in the urine.
Die production of "free radicals", such as
hydroxyl, chloride, or other are the biggest factors in a disease process, no
matter what stage is the disease. This is the main reason that DMSO, is useful
a "free radical scavenger", in the treatment of many ailments, such
as cancer, arthritis, and atherosclerosis.
DMSO replaces water in the living cell, because of its
remarkable property, it can cure sick cells by destroying free radicals within
the cell.
DMSO also increases the permeability of the cell membrane,
and allow flushing of toxins from the cell.
Allergische reactions are reduced by the DMSO, which
increases the resistance of the body against infection, by a range of complex
mechanisms.
^
Drug delivery properties of DMSO
Diverse in DMSO dissolved drugs maintain their therapeutic
activity, as well as their specific characteristics over a long period. DMSO
receives not only, but amplified and multiplied the effect of drugs which are
dissolved in it, so that it allows lower doses, than that which would normally
be needed to obtain a satisfactory result. Various drugs that are dissolved in
DMSO, as insulin, cortisone, antibiotics and cytostatics, could be applied in
smaller doses, without affecting its therapeutic efficiency is reduced.
Furthermore, their adverse effects are best reduced when they come into the
DMSO solution. In organ banks around the world, organs and tissues are stored
in DMSO and conserved in order to keep it available for transplantation.
Tissue, such as red blood cells for transfusion, and semen for artificial
insemination, are preserved in the same way. When penetrating carrier for drug
DMSO is unsurpassed. It transported easily, needed pharmaceuticals, in every
part of the body for therapeutic effects. It happened cell membranes and
tissues. It is inevitable to be able to penetrate the endothelial cells of the
arterial walls coatings, the meninges of the brain, healthy skin, mucous
membranes, and other tissues.
The intravenous and intramuscular injection of DMSO is
transferred into the liquid of the head and the spinal cord. When injected in a
sheath which surrounds a nerve or muscle, it goes rapidly into the blood
stream. The central nervous system responds to DMSO different than the normal
drugs because the DMSO crosses the blood-brain barrier. Other drugs will pass
through this normally impenetrable blood-brain barrier, if they were
molecularly mixed with the DMSO solution.
Basic chemical processes on the nerve cells are stimulated
level in the central nervous system by the use of DMSO. It allows the transport
of amino acids to the brain where they take part in the synthesis of glutamic
acid and other elements, which are integrated in the metabolic cycle of the
brain to provide drive to the functional activity of neurons and brain. These
functional stimulation allows the correction of many neurological syndromes,
characterized by menthale weakness, reduced brain activity,
Loss of memory and depression or distress. On an
experimental basis DMSO was topically, subcutaneously, intramuscularly,
itraperitoneal, intravenous, oral, intrathecal, and administered by inhalation.
It was intilliert in the eyes, on the mucous membranes, and in the urinary
bladder. It was experimental animals, including rabbits, hamsters, rhesus
monkeys, chickens, dogs pigs, guinea pigs, rats mice and goldfish just given as
humans. In the US, DMSO currently still an experimental drug for the
human consumption but it has been approved as an veterinärisches
medicines used to treat acute muskoskelletalen injury and inflammation in
horses. At the time when I wrote this book, which DMSO remained at the FDA
approval, solely for use in interstitial Zysitis, a relatively rare disease of
the bladder. It is used for 30 years in parts of Europe and South America by
clinics for people.
^
The major pharmacological effects of DMSO
The major pharmacological effects of DMSO
DMSO has a wide range of pharmacological effects, including
the penetration of membranes, as well as an anti-inflammatory and
lokalanalgetischen effect. It inhibits the growth of bacteria, promotes the
excretion of urine, holds the secretion of cholinesterase back, changes the
effect of a co-administered drug, acts as a solvent for collagen, provides a
specific or non-specific strengthening the immune system, and produces local
vasodilatation. In addition, DMSO transported effective local anesthetic into
the deeper layers of the skin, as well as through the tympanic membrane, which
allows a surgical incision without pain. Report In controlled studies
veterinarians over a wide range of effects in their animal patients with
multiple problems, including muskoskelettaler injury, acute inflammation, and
skin problems. When combined with other drugs, is DMSO effective than when used
alone. These case yielded Dr.Jacob opposite the University of advanced medicine
an example: "We have treated a number of patients with cellulitis
(inflammation of the cellular tissue and connected), but that DMSO had only a
limited effect on the symptoms. I have the DMSO combined with an antibiotic
even though the solution itself has antibacterial properties. It has bacteria
that were actually resistant to the administered antibiotic converted so that
they were sensitive to the same antibiotic again. "This DMSO property of
Resensiblisierung of bacteria that could potentially replace a group of
outdated antibiotics in the armor of medical practitioners are. In 1968, based
on two years animal experiments started with the first human clinical trials,
in the nosocomial and health centers of Santiago, Chile. DMSO, combined with
many drugs, administered for the most diverse diseases, with mental
retardation, senility, rheumatic and cardiovascular cardiovascular symptoms,
chronic respiratory insufficiency, skin infections and other problems. From
these clinical studies on the behavior of individual medicines with DMSO
resulted excellent results, which exceeded the results by far, which have been
supplied from the United States or Europe. DMSO was there previously solo
administered, not in the form of a combined therapy DMSO. Furthermore exhibit
reflections of the primary pharmaceutical modes of action of DMSO indicated
that it, by parenteral administration (in a different way than through the
intestinal tract, especially by the injection into the veins, and into
subcutaneous tissue), a more rapid and more effective therapeutic effect with
itself brings, as in topical (on the skin), or oral applications. For example,
after two topical application per day by DMSO to rats, rabbits and dogs over a
period of several weeks, no deposits of labeled DMSO in the organs
of animals found. (DMSO has been marked by a dye).
Autoradiograms (photographs, radioactivity track), which were made twenty hours
after skin application in rats did not show any deposits in the brain, spine,
spinal discs, the fat tissue or the adrenal glands. After a three-week
administration to the skin of dogs, no deposition of radioactivity was
observed, except in the areas of the skin and the underlying muscle that
directly with the DMSO in contact
came. In contrast, the result of intravenous injection of
DMSO in laboratory animals, the permeation of almost all organs in the bodies
of animals. The DMSO has administered intravenously, intramuscularly,
intrapeitonial, a very low toxicity index. Therefore, the therapeutic dose is
well below the toxic. (See Chapter 5) Topical and oral use in humans is
different from the one that is used in animals. DMSO is readily absorbed when
it is administered to the human skin, with a peak level occurring after 4-8
hours. The orally administered DMSO is absorbed rapidly, it reached the peak in
the blood serum within 4 hours, it is no longer in the blood serum after 120
hours detectable. Both substances, unconverted DMSO, and its metabolite,
dimethyl sulfide (DMSO2), are excreted through the urine.
Dimethyl sulfide (DMSO2) will appear in the blood after 48
hours, it is up to 400 hours detectable.
Scientists concluded that the pharmacological action of the
DMSO persists in the body, even after it was administered through the skin, and
by ingestion. It is excreted partly as unchanged drug as well as dimethyl
sulfide (DMSO2) again. The DMSO is rapidly absorbed by humans when it is
applied to the skin or taken by mouth. Since the blood levels after
administration are lower than the skin, than after oral administration, the
skin absorption is apparently less extensive
as the absorption by the gastrointestinal tract. Although
the solvent willingly most membranes of the body passes through, without
destroying the integrity of the membrane, it does not penetrate the nails, the
hair, and the enamel. Steroids, which are dissolved in DMSO, including
hydrocortisone, and the hormone testosterone are three times through the skin
permeability.
DMSO transported into the deepest layers of the skin to a
reservoir to apply hydrocortisone and hexachlorophene that for sechzen days
left, and a loss by washing the skin with soap, water, and alcohol resists. The
DMSO relieves inflammation and swelling significantly by reducing the
inflammatory exudate, and promotes the development of granulation tissue.
Within tissues, such as the membranes of cells or organelles, it makes steroids
in the body more easily reach their objectives. Keloids shows a resolution as
well as increasing return to normality when it is exposed to a DMSO-therapy. A
concentration of 50 to 80 percent, applied three times a day, will flatten the
scar raised after several months. Microscopic changes on the skin to show the
disappearance of the collagen bundles. In a medical Revue article, published in
January to June, 1985, the interactions that the therapeutic benefit, the
metabolism and toxicity of dimethyl sulfoxide were discussed. The author,
Dr.B.N. Swanson, gave a fairly summary picture of the substance. He described
DMSO as a clear, odorless liquid, inexpensive to produce as a byproduct of the
paper industry, and is widely used in the US as a solvent, but its medical use
is currently restriktiert by the FDA, the palliative treatment of interstitaler
Zysitis (bladder disease), and various experimental applications. Skin
manifestations of scleroderma appear to dissolve as a result of topical
application of high concentrations of DMSO. From a limited number of clinical
trials results that intravenous DMSO could be useful in the treatment of
amyloidosis, perhaps by the movement of amyloidoses bearings from the tissues
into the urine. (In amyloidosis is the deposition of amyloid in the tissues, in
amounts which are sufficient to harm a normal function. amyloid is a
glycoprotein, similar to starch, which deposits in the internal organs.)
Topical applications of DMSO offer a rapid, temporary relief of pain in
patients with arthritis and connective tissue injuries. In its balanced
Evulation Dr. Swanson said that the claims of the anti-inflammatory effects, as
well as the healing-promoting effects of DMSO currently appear to be
unjustified. There is no evidence that DMSO can influence the development of
degenerative joint diseases, for this reason, the use of DMSO should be
considered carefully, exclusively for relieving treatment, and not to exclude
regulärerer antiinflammatory agents. The safety of DMSO in combination with
other drugs has not yet been fixed; About Neurotoxic interactions with sulindac
was reported. In the experimental animals intravenous DMSO was as effective as
mannitol or dexamethasone in reversing celebraler edema, and intracranial
hypertension. An initial clinical trial, conducted on eleven patients, tends to
support this previous assumption. DMSO allows other chemicals to penetrate the
tissue, and for this reason mixtures of DMSO and idoxuridine in the topical
treatment of herpes zoster in England are used. Negative reactions to the DMSO
are commonly found, but they are usually slightly, and contiguous with the
concentration of DMSO in the drug solution. Consequently, it is at the most
common side effects in order after oral administration which avoided such as
skin rash, and pruritis (itching) after dermal application, intravascular
hemolysis (destruction of blood elements) by intravenous infusion, and
gastrointestinal complaints to a large extent may be, by the use of dilute
solutions. In most clinical trials over the DMSO no experimental design was incorporated,
which would have been important for the objective, statistical evolution of
effectiveness. Randomized comparisons between DMSO, a placebo, and known active
treatments were rarely completed. The final approval of topical DMSO particular
for the treatment of rheumatic symptoms will demand a multrizentischen,
randomized comparison, between high and low concentrations of DMSO, and an
orally active, nichtsteridualen anti-inflammatory agent.
^
As DMSO is applied topically
The substance is usually administered in liquid or geliger
form to the surface of the skin; in liquid form, it would be more effective,
however, people tend to gel preferable. It should not be rubbed, but only
painted in a thin layer or spotted. As Dr. Jacob, Mrs. Sandy Sherrick showed
how they could apply the solvent on their neck or back, can be seen in the
60-minute video documentary, he said: "Now, if they raise it, do not rub
too much , Simply plug it in to the skin to apply, and it is moving in. Let it
be longer than 20 minutes, up to dry for one half hour. It is never completely
dry, should be something left, can wipe the just. "The treatment must be
individualisert. The optimal concentration varies between 50 and 80, and even
90 percent. In general, the face and the neck are more sensitive to the DMSO,
than other parts of the body, and any higher concentration than 50 percent
should be used here. Topical concentrations of DMSO should be kept under 70
percent, in areas where there is a reduction in the blood circulation. Not all
clinicians agree with the fact that this lower concentration is necessary. You
should start treatment with lower concentrations until the skin has built up a
tolerance. Look out for skin irritations, before switching to a higher
concentration. In some rare conditions such as scleroderma or Peyronischen
disease (when plaques or strands of limited fibrous tissue covers the penis,
which causes deformity and jocular erection by itself) take the treatment
periods longer than one year. How often do you administer the DMSO solution,
based on the judgment of your physician, and the particular clinical problem.
When the solvent in which takes place a long time in places a minimized blood
supply, administered antibiotics should attend the therapy, despite its bacteriostatic
qualities. The most common group of health problems, because of the human
topical DMSO apply at home, probably includes acute muskuskelettale injury and
inflammation with a. The sooner the agent is applied to the injured area, the
more dramatic is the result. Here is an example: A 14 year-old boy was hit in
the face. A one-inch large laceration with swelling broke over the ridge of his
nose, and extended to the eye. 6 ml. DMSO were administered in this place. 15
minutes later the pain, the swelling began to subside and the skin irritation,
and disappeared completely within 4 hours. The skin should be clean, dry, and
undamaged, not only in muskoskelettalen problems, but with any other topical
use of this medicine. Remove any excess skin oil, or sweat. Make sure that
there was heavy metals and insecticides is not allowed to dry out on the skin
surface. The medical complaints that start at best it is acute post-traumatic
injuries of soft tissue, the neck, the shoulder, and the back, distortions and
compressions of the larger joints of the upper and lower limbs, acute
post-traumatic injuries of soft tissue, accompanied by subacute intramuscular
bleeding, on the trunk or limbs, as well as acute bursitis, of which the major
joints of the body are affected. 8-12 ml of 70 liquor DMSO mixed with water,
applied to a large area in and around the injury, 3 times a day, promise an
effective cure for 4 of 5 persons. Some progress can be observed even within 24
hours. Measure out the amount of DMSO, which is necessary after your
assessment, cover the affected area. Brush the solution then applied to the
skin. For example, if you want to treat gout in the big toe, wear 6ml of the
substance on the toe, and the entire front foot on. Usually one needs to
achieve several minutes for brushing an appropriate dose. Let the treated area
for 30-40 minutes uncovered; the remaining solution should then be wiped off by
an absorbent material to prevent damage to your clothing. The relief of
arthritic pain, and the swelling occurs within 30 minutes, and holding for one
to four hours. Repeated applications, up to four times a day will keep the pain
of acute gout sufficiently under control. If 60 is administered to 90 owned
DMSO to the skin, warmth, redness, itching, and sometimes hives may occur. In
most cases, these local irritation disappear within one to three hours. The
skin surface behind the knee and elbow joints, the skin of the face, and the
armpit are sensitive to high concentrations of the solvent. If a 60-90 percent
concentration is applied to the inner surface of the hand, can there wrinkle
the skin and remain for several days in this state. Some liniments brought pain
relief, reduced muscle spasms, increased freedom of movement of the affected
arthritic joints, through a myofaszinalen effect. Normally liniments eliminate
the pain only as long as the irritation persists. The DMSO works differently.
In contrast, it disappears, the skin reaction in the form of hives and other
irritations, while the beneficial effect remains for several hours.
An interesting observation is that the administration of
DMSO often leads to an affected joint or region to a pain relief at a different
location. DMSO has systemic modes of action. It has a dampening effect on the
central nervous system, and achieved through the bloodstream course all areas
of the body after being absorbed through the skin.
^
As DMSO is supplied
As DMSO is supplied
The only DMSO solution, was commercially available in a
purity for medical applications was Rhimso-50, produced by Terra
Pharmazeuticals, Inc. From Buena Park, California. It is sold by the company
Research Industries Corporation, of Salt Lake City, Utah. Lately also market
other traders DMSO in the form of gels, as well as at other levels than the 50
percent of Rhimso-50th When brand Domoso it was a pharmaceutical grade of DMSO,
with a concentration of 90 percent, suitable for injections, and to be mixed with
water to reduce its Konzentation for topical application and oral ingestion.
The Domoso was over 13 distributors are cross referenced by the United States.
After the FDA stopped its production, Demso was another branded product that
over a 75-percentage decreed concentration, produced the ideal thickness for
application to the skin (excluding the face and neck), by the Commercial
Laboratories of Florida, an ethical drug company that DMSO for prescribing
produced by doctors. It was licensed by individual states, under the strict
regulations and rules that affect all pharmaceutical manufacturers. DMSO is
legally available for veterinarians, as well as research applications in the
people, in countries where such research is permitted by law. Rhimso 50 comes
in 50cc (cubic centimeters) Aufstechflaschen. Domoso was delivered in
half-liter bottles and two and a half liter bottles for veterinnärische
application. These products were mainly sold to doctors or pharmacists, but
also many shops were made with the sale to the public. Human skin reacts to the
contaminants, and the excessive addition of DMSO. The contamination by acetone
can have serious medical consequences. Due to its low molecular weight acetone
is easily transported through contaminated with acetone DMSO in the
bloodstream. Sustained exposure to acetone can cause liver damage and death. So
take heed when buying crude DMSO on your friendly local dealer. Although the
side effects and toxicity in Chapter 5 will be discussed, we would like to note
here that represents the most effective means of reducing the damage caused by
the DMSO-use burning or rash, rubbing the surfaces topically treated with aloe
vera cream. Aloe Vera is a transparent mucilaginous gel which is prepared from
the leaf of Aloe, a plant kaktusähnilchen. It can be used as-the follow-up for
each topical DMSO application use is recommended after each use DMSO, whether
skin irritation occurs, or not. Aloe Vera is a good contraceptive for these
external irritations. The common use of oral doses is between one and two
teaspoons a day. The drug is mixed with tomato or grape juice to mask the
taste. People with arthritic conditions benefit from the oral ingestion of 50
percent DMSO and proceed with the topical administration. Some doctors administered
patients, up to three times a day DMSO intravenously. This is not by the
technique of intravenous infusion or drip, but it is a slow push into the
bloodstream at once. This method is reported that it is capable of the most
serious degenerative diseases such as cancer, atherosclerosis, crippling
arthritis, multiple sclerosis, Parkinson's disease, and to treat others. As
much as 20 cubic centimeter DMSO in a thrust, have already been given by
injections. The drug was diluted to an approximately 25 percent concentration
by sterile water.
The slow intravenous drip procedure is performed over a
period of 2-3 hours. Here 50-100 cubic centimeters are placed in a bag with
500ml glucose or saline, to be subsequently dropped into the arm vein. The EDTA
(Etylendiamintetraesigsäure) chelation, the intravenous administration of a
synthetic amino acid, the ionic calcium from the bloodstream removed should be
administered at the same time, wherein the chelating agent should be a part of
the intravenously administered DMSO. EDTA itself, reduces often the symptoms of
arthritis. Please note that this injection procedures must be performed by a
physician who is trained in the use of DMSO and EDTA. There are some possible
side effects, which, although completely reversible and harmless, but scary for
someone who is not familiar with it, face them. As with any other medicine, the
doctor should be neat trained and experienced in dealing with these compounds.
^
Chapter 4
General medical applications of DMSO
Ruth P.Lewis, from Sarasota, Florida, 64 years old, had such
pain by rheumatoid arthritis that they not could not move without the help of a
four-legged Gehgerätes. In addition to their 20-year-old joint disease, she
retired recently of a back injury, and their physicians verordeneten her for
the next 6 months, absolute bed rest. That was the only thing that she advised
her ... Mrs. Lewis realized that if they would remain so long in bed, it could
happen that it never cease to be his to go, even with the use of its walker possible.
Rather than give up their lives, and to lie flat on her back in bed, the woman
called her son and your husband on to bring them into the Douglas Hospital for
preventive medicine, which was then located in Marietta, Georgia, to join the
flow to undergo treatment by the DMSO. "I had previously many months
severe pain in my hips, and legs, visited specialists, diagnostic clinics, had
health maintenance stays with Sreckverbänden, equipment and other
procedures." Said Mrs.Lewis. "When I saw the doctor's office for DMSO
treatment entered, I was not able to put both feet on the ground. After two
weeks of intravenous DMSO treatment I walked unaided from this practice,
impossible, without cane without ever any help. It was impossible for me for
over a year, to close my right hand. It kept me even awake at night, by the
severe pain. However, after the intravenous, topical, oral and DMSO treatment,
I am now able to my hand tightly close. The arthritis did not come back.
"Said Ruth Lewis. "I can not put into words what this drug did for me
there. I recommend it highly on. I looked at my hospital stay, many people come
and go; all went well beyond, "she said.
XXXXXXX
In January 1980, I injured my knee, and had insane pain,
with periods of immobility. Wrote the 62 year-old retired schoolteacher Gertie
D. Brown, of Port Charlotte, Florida. "My orthopedic surgeon explained
that I had a torn ligament (muscle band), which had to be surgically operated.
But I rejected the knee surgery. Six months later I heard from Dr. William
Campbell Douglas through the media (television), as well as from the wonderful
results that his patients who experienced this through the use of DMSO. I
contacted on the spot Dr. Douglas Hospital, and received the treatments. I was
ultimately 8 intravenous DMSO treatments, and with me were also wonderful
results on. "
Mrs. Browns intravenous DMSO doses were quite small. Most of
comfort came from the topical application of DMSO on her injured knee and other
joints that have given her over the years severe pain. "The knee was not
fully loaded, so when I walked a little, it felt weak." Said Gerti Brown.
Before I go to bed, I apply a small amount of topical DMSO, and the next
morning I am ready to return to my everyday activities. I recommend it continued
most strongly that people try the DMSO.
XXXXXXX
Marvin Combs Warein handsome, six foot tall man, which one
did not look at his 62 years. He is still working in construction as a building
contractor. Mr.Combs said: "After I was hit by a car accident as a whip,
so that more stringent all the other health problems helped me DMSO to a
decisive improvement of my back pain, as well as my other worries. Medicine
that was prescribed to me by other doctors, at all did not yield any results.
The lawyers who dealt with my car accident, however, were of the opinion that I
should continue with my previous doctors. So I interrupted the DMSO treatment.
Again, I got no results, through the countless painkillers that were
prescribed, and also produced high prescription costs. "Because I know how
I feel right now, I will certainly return to DMSO treatment (after the
accident, the requirements were not yet closed), which was the only thing I can
tell honestly that brought me relief, even in the tougher issues that I already
had. It's wonderful for me that there is something that helps the population to
eliminate the filling quantities of pills in their organisms.
"Unfortunately, the payment for a medicine such as DMSO is not reimbursed
by health insurance because it is not a legal form of represents therapy.
Notwithstanding, said Combs medical records, that: "He came to severe pain
in his neck, left arm, right forearm, little sensitivity in both feet and
general arthritis. After five days, he slept like a baby because he had absolutely
no pain. The relief occurred after the third intravenous administration. He was
to return immediately after the completion of DMSO treatment able to lead a
normal life. "One of the methods to determine progress by use of DMSO in
weak arthritic joints, grip strength of hands is in front, and to measure after
DMSO treatment , The technique involves inflating a rolled blood pressure
monitor, the same instrument that is used to measure blood pressure, up to 20mm
of mercury. The patient then takes the cuff, and pushes it as hard as possible,
and to read this on how high the mercury deflects the connected manometer. A
normal strong man should manage to generate a pressure of 200-300mm Hg; a
standard-sized woman creates 100-200mm Hg. Before DMSO treatment Combs could
move with each hand the mercury only up to 40 mm level. After 3 days of
intravenous DMSO treatment, he redoubled his strength, erschaffte 80mm with
each hand. It is probably even more powerful when to the DMSO
returns treatment.
XXXXXXX
Another contractor who 61-year-old Russell Whitney, from
Arcadia, Florida, is a serious case of arthritis of the extremely high daily
intake of sugar consumed, -einundfünfzig- teaspoon of it in its refined food.
This high sugar intake is quite conspicuous, so that they could contribute to
arthritic disease of the patient. The harmful effect of sugar on the human body
is discussed in detail in Chapter. 7 Mr.Whitney experienced excellent results
through the use of DMSO. His consumption of overly refined food, and sweets
prevented the solution not from exerting a beneficial effect.
The man's ability to sleep without pain, improved greatly;
the swelling of his finger joints disappeared, he reduced all his painkillers
within five days after it had begun with the DMSO treatment. The patient's
sportsmen and hunters. Immediately after its intravenous DMSO infusions, he
traveled to a safari to Africa, which lasted three months. The DMSO treatment
allowed him again to lift, cooking and also the loading and firing of heavy
hunting rifle, as well as walking along jungle trails without pain.
^
General applications of DMSO
General applications of DMSO
First, an explanation of the editor via the DMSO was in the
journal Desk Reference 1980 printed that read as follows: ". There are no
known contraindications" Of all the areas in which it applies the
sulfoxide, the public seems to most interested be to use it for various forms
of arthritis; Anyway, let doctors know that has the solvent over a vast field
of applications. In fact, in the medical and pharmaceutical literature, is
reported about this Arzneineimittel that it has the widest range and largest
number of therapeutic applications, each having a different individual
chemical. DMSO has approximately 40 to pharmacological properties which would
be beneficial in the prevention of symptomatic relief, or the pathological
abolition of human organic diseases. Subsequently 16 of its main therapeutic
properties are enumerated:
1. It blocks pain by interrupting the transmission in the
small cFasern, the non-myelinated nerve fibers.
2. It is anti-inflammatory
3. It is bacteriostatic, fungicidal, and virostatic
4. It transports Numerous pharmaceuticals through the
membrane
5. It reduces the incidence of platelet thrombi in the blood
vessels
6. It has a specific effect on the cardinal Kontrakttilität
by inhibition of calcium to reduce the workload of the heart
7. It acts as a sedative, even if it is simply rubbed on the
skin.
8. improved antifungal and antibacterial agents, when
combined with it
9. It is a vasodilator, probably connected with the release
of histamine in the cells and by inhibiting prostaglandin
10. It inhibits the release of cholinesterase
11. It tends to soften collagen, by its special effect
crosslinking
12. It captures the free Hydroylradikal
13. It stimulates several types of immunity
14. It is a potent diuretic, especially when administered
intravenously
15. It drives the formation of interferon in the body
16. It stimulates the healing of wounds
The medicine is prescribed in many parts of the world. For
example, in the US in 1970 be prescribed in veterinary medicine, as well as
1978 in human medicine. It is used in Canada in scleroderma; In the UK and
Ireland in shingles, in Germany and Austria for a lot of diseases, including
bursitis, tendonitis, and arthritis; in Switzerland. for a variety of ailments,
as well as in Russia for the widest range of medical applications
Various light-skinned people, those with red or blonde hair,
and blue eyes react more sensitively to the DMSO. In these, the topical, oral,
and intravenous concentration should be herabgestzt to 50 percent or less,
specifically the one that is applied on the face or neck.
DMSO seems to grow cumulatively in its effects. Experts
observed, and reported that less DMSO is necessary to get results. It is about
an "distinctive" quality of a drug, as increasingly higher doses are
required for most pharmaceuticals. DMSO attacks the disease itself, not just
its symptoms. DMSO zirkelt a completely new method of treating a disease, and
therein lies the difficulty with the medical community, and the watch dog like
bureaucrats. It was classified as a medicinal product that is useful for
individual, or an entire category of diseases, but DMSO is really more than
just a drug. In the 60 minute Fernsehbeitag in the reporter Mike Wallace Dr
Jacob interviewed, asked that Dr. Jacob: "Is a drug with so many alleged
uses as arthritis to tennis elbow, burns up to spinal cord injury, by menthaler
retardation to baldness --- is a drug not automatically suspect "Dr.Jacob
replied," No question, I think it's one of the reasons why it has
problems. And if I could just do it all over again, perhaps it was the biggest
mistake I made, Mike, to represent it at the beginning of the way I did it. I
think if I would have said, it would be good for ankle sprain, but only if the
sprained ankles on the left side, DMSO might have admitted today. In fact DMSO
was dramatically therapeutically to be believed. For example, wearing a newspaper
report of 11 January 1981 published in the newspaper Ocala Star Banner
headline: "Doctor asserts DMSO rescued 11 people"
The following story:
SAN DIEGO (AP) ---- A doctor at the University of San Diego
writes the controversial drug DMSO to the rescue of 11 human lives, suffering
from various head injuries. Dr. Perry E. Camp, a neurosurgeon of USCD Medical
Scool, said Friday that dimethyl sulfoxide for 11 of the 30 people shown to be
effective, which were judged to be "close to death", and for which other
lifesaving methods were tested have proven ineffective. "When you save in
patients like this, only one out of ten, that's phenomenal." Said Camp,
"the event that we ever have survivors ... ..... sounds like not much, but
is extremely encouraging, "said Camp. "Some researchers claim that
painkillers would be the aspirin of the 21st century," wrote the New York
Daily News. Such dramas that have been reported through the press, DMSO did not
popular with the orthodox medical community. It exerted too much pressure on
doctors to use a pharmaceutical, with which they were not familiar. Without
question, any legitimate scientific opposition to the general medical
applications of DMSO is at a minimum. Possible therapeutic doubt exists only in
the minds of doctors, they have not even informed by the published medical
studies that have been published in the scientific literature. When they hear
that a doctor devalues the means, you will find out that he is not yet
applied either currently, or only slightly Literraturrecherche has operated.
Resistance is expressly Civic. In 1965 DMSO got bad press, and the FDA
disapproved then. Once the bureaucracy does, there are difficulties to regain
its original specifications. Nowadays, there are still enclaves of resistance within
the FDA. The political opposition is not based on anything solid, but on
emotions, and greater Leichtfertigkeitgkeit to say something negative. Also
economic opposition is generated by the large, parmazeutischen companies since
DMSO is not patentable in the general sense. His broad medical application
areas would reduce the value of large amounts of pharmaceutical agents, on the
pharmaceutical companies have patents. It is natural for it to find little
enthusiasm for such a non-patentable therapeutic substance in which one is able
to produce these so cheap and promote.
Consider, for example, the four "wonder drugs" for
arthritis, are currently pushed by Parma firms and doctors: Motrin, Tolecin,
Nalfon, and Naprosyn. About all of them turned out to be ".......... about
as effective as aspirin ..... ............ are that all differences
negligible" are, citing the issue of Resident and Staff Physican, page
109. But what about the cost and safety of these pretenders to? When I wrote
these lines, Nalfon cost the patient $ 175 per month at least. That's about
twenty times more than the cost of effective gleichwertg aspirin, and ten times
more than the cost of topical DMSO .------- a tough pill to swallow. to swallow
Derb, in fact. As an example, the following possible side effects of Nalfon,
compared with the non-toxic DMSO:
Magen-intestinal hemorrhage, and hemorrhagic death
Geschwüre
Gastritis
Auftreten abnormalities, caused by a possible hemorrhagic
stroke
Hemolytische anemia (destruction of blood vessels)
Gehirnhautentzündung
Vaskulitis (inflammation of blood vessels)
Herzversagen
fatale aplastic anemia
These side effects of Nalfon were reported in editions of
the magazine The Medical Letter on 4 Aprill 1980 and on 6 February 1981st They
also include more personal changes and paranoia. The latter two are serious
side effects, psychiatric signs that could lead to a murderer, or suicides, or
both. DMSO has proved interesting, as well as various biological properties.
Some of these are briefly touched on in this chapter, as well as others,
explained to the deeper detail in the following chapters. These later chapters
are devoted exclusively to the individual disease states and state systems, has
been felt for the DMSO to be effective.
^
Protection against radioactivity, freezing and thawing
After DMSO was spread on the foot of a rat, the foot has
been shielded from the effects of radiation. The radioprotective properties of
DMSO were reported in 1961 for the first time. DMSO protects a number of cells,
cellular systems, and all the animals against the lethal and mutagenic effect
of radioactive rays. The protection of the entire body against radioactive
radiation is based on a cellular level, but on a pharmacological mechanism. At
the cellular level, protecting the amounts of glycerol and DMSO, which actually
prevent frostbite, equally against damage from radiation radioktive. This was
demonstrated on the basis of bacteria, human kidney cells, and tail bone of
mice which had been irradiated in the living organism. Topical application to
the skin of sechzen days old nestling rats, this protected against induced
radioactivity damage. One method to avoid radioactive injury of urinary bladder
and the rectum in cervical cancer patients was elaborated by medical
researchers from Russia. Released in March 1985 in the Russian Radiologists
Journal Meditsinska Radiologiia, this method based on the local administration
of dimethyl sulfoxide as radioprotektives means before a meeting of
interstitial irradiation, which was executed by the AGAT-B irradiation
apparatus. The accompanying radiation therapy, with DMSO as a protective agent,
was offered twenty-two cervical cancer patients. The control group included a
59 patients, however, were given the same treatment without DMSO. The emergence
of early reactions and subsequent injuries to the rectum and the urinary
bladder, were remarkably low in the DMSO group. The DMSOgeschützten patients
experienced no radiation burns, while the unhappy group of test patients died. There
is evidence that DMSO supports red blood cells during freezing and thawing. The
proof of preventing cellular freezing by DMSO was published in a report of the
1959th There is little doubt that the solvent, at concentrations between 5 and
10 percent, a large number of cellular systems excellent protection against
damage has caused by freezing or thawing.
^
Injuries of the brain and spine
As an important potential advance in the prevention of
paralysis after injury to the brain and spinal cord, DMSO has been studied in
four learning centers for these applications. One of these was the medical
faculty of the University of Miami, practiced at the Jack C. De la Torre, M.D.,
an associate professor of neurosurgery and psychiatry, as well as head of the
Department of Neurological Research. In 1992 he worked with the compound for 12
years. Dr. de la Torre published his inventions for the first time in November
1980, at a scientific conference of DMSO Society of Florida, Inc., held in
Sarasota, Florida. In experimental monkeys, which an occlusion of the middle
cerebral artery was added to the blood vessel in the brain that controls motor
function, prevented Dr. de la Torre whose paralysis by administered DMSO. The
DMSO-treated monkeys did not suffer from the serious neurological damage caused
by the stroke, which would have occurred if they were left untreated, or if
they had been treated with corticosteroids, the currently conventional method
of treatment. The stroke, which caused over half a million deaths or more among
Americans, is the second leading cause of death by cardiovascular system
disease. There are many facets of this pathological process --- hypertension,
oxygen deficiency, inadequate blood flow, loss of enzymes --- and the DMSO is
well equipped, they are all fixed. The DMSO has to be effective, be
administered within 4 hours, during the first 90 minutes it would be best, says
Dr. de la Torre. I offer a comprehensive implementation of its DMSO research
bereffend brain and spinal damage in the chapter. 9 At the medical faculty of
the University of Oregon, where Dr.Jacob is busy, intravenous DMSO was
administered to patients with many severe brain damage. In a group of patients
who Barbiturantes and mannitol were given, the brain pressure remained
elevated. As 40 owned DMSO was administered (one gram of DMSO per kilogram body
weight), the pressure reduced to normal, within 3-5 minutes. Barbiturantes and
mannitol are presently considered as the best-available treatment method of
traditional medicine for such brain injuries but DMSO proved better Dr.Jacob
said in an interview. In several animal studies with cats, rats, and dogs,
which were conducted at three universities, DMSO was administered intravenously
into the backbone of the animals within one hour after an injury, and brought
the reversal of losses, which would normally irreversible. "We had an
experience with two patients at our medical school in Oregon, where the DMSO
was added one hour after could be assumed that irreversible damage --- an
immediate, complete Quadra Plegie --- disappeared with two people, it was the
savior for her, she left the hospital, "said Dr.Jacob. For the absolute
therapeutic effect, it is considered essential to give the DMSO intravenously
within 90 minutes after brain damage. "If the gray matter of the brain
seems to be affected by any injury, at least in experimental subjects, it would
be necessary to give DMSO very quickly. Each emergency room, and each clinic
should have it in stock. In paralysis the agent at a dose of one gram, per gram
of body weight should be administered. The concentration of 40 percent is
recommended in paralysis, although it prolongs the Butungszeit, "so
Dr.Jacob on. "We had three patients who were admitted to our medical
center paralyzed after an injury, the first 5 hours of the second 6 hours and
the third nine hours later. Historically, we thought that their chances of
recovery would almost at zero. Two of these three can go back, as a result of
our with intravenous DMSO, although the infringement dated back longer than 1.5
hours. "The Douglas Center advocated, and Dr. de la Torre agreed that 2
grams per kilogram of patient body weight as initial dose should be given in
these traumatic cases.
^
Hämmorhagischer stroke and head wounds
Hämmorhagischer stroke and head wounds
Also, although 40 liquor DMSO prolongs bleeding time,
although it should be noted, apply it in the treatment of an embolic or
hämmorhagischen stroke. A hämmorhagischer stroke is the bursting of a weakened
blood vessel in the brain, often headache, nausea and ringing in the ears
caused, just before the occurrence of this celebral vascular accident. An
embolic stroke is the clogging of a blood vessel through a plug. DMSO is other
treatment methods for the high-speed treatment of wounds superior in the brain
where in which a large amount of Hämmorhage is present. The key to success by
DMSO, at a hämmorhagischen stroke, or any other problem, as it has been put
forward is to use it as soon as possible after the stroke, or head injury
occurred. The healing properties of DMSO are working to bring the injured
tissue back to normal. See Chapter 9, and the notes to obtain more extensive
information on the use of DMSO in an embolic stroke or hemmorhagischen.
^
Brain injured children
DMSO has been found in cases of menthaler retardation, and
the Downs Syndrome as effectively. As Penetrant it transports drugs across the
blood brain barrier, whatever is the biggest problem in the treatment of the
brain. It was also employed to secure oppose all forms of psychoses. Brain
injured children given oral DMSO, at a strength of 50 percent. It is especially
in affected babies advantageous where a lot of half a gram per kilogram of body
weight will be given by mouth. The effectiveness is perceived by the child's
parents, as measurable changes would not reach the level of statistical
significance, for the person who administered the treatment. A cholinesterase
inhibitor, the drug would stimulate the transmission in the central nervous
system, what would it be well worth that means to try even over several years
to restore a brain damaged child. Explore the Chapter 10, for more details on
the DMSO treatment of children with mental retardation, and the Downs Syndrome
to.
^
Sciatica and disc problems
With aching back end, especially disc disease, causing
excruciating pain backbone, in surgery. show European reports that the duration
of treatment, and the techniques can be reduced by the use of DMSO to 50
percent. Administered to 20-50 ml of 20-percentage DMSO, combined with the
local anesthetic Xylocaine, injected intramuscularly every day, in the painful
area, this is a legitimate adjunct towards another treatment. Injections should
be given three to five days in a row.
The following text is part of a letter, written by Patrick
J.Potter from Beavercreek, Oregon, and was sent to the President, the
Conference Committee on aging the erhrenwerten Claude Pepper, on 25 March 1980:
realized I, for myself, have, I was almost completely free of pain since I was
injected with DMSO by Dr. Stanley Jacob. My pains were at precisely the scar
tissue surrounding the sciatic nerve, as a result of two surgical spine
patients, and it made me a surprise fall to the ground-which required a
constant need for pain medication, and the use of a stick to walk. After two
injections of DMSO I was to finish in a position to use the stick, and after
six injections by Dr. Jakob I was able to discontinue painkillers, now I feel
better, and owe everything Dr. Jacob and DMSO ........... Unfortunately, not
everyone has, which is treated with these difficult back problems, such
excellent results on.
^
Keloids, scars and burns
Topically, and repeatedly applied DMSO flattens the raised,
nodular, lobulated linieare mass of scar tissue from keloids, and removed a lot
of discoloration. It does not cause the disappearance of parallel bands of
dense collagenous material, but it has a positive effect on it. It can also be
used as an aid in order to reduce scar formation in chronic acne in which the
fibrous papules have developed at the site of the hair follicles, as
conventionally, on the back of the neck and
Hairline. In a study of 10 people, which up to 80 owned
topical DMSO was administered several times a day, was a flattening of the scar
tissue, as well as a loss of collagen, the material surrounding the fibrous
bundle observed. DMSO would be effective in the prevention of
Sekundärverwachsungen from previous surgery. This would be carried out,. By the
instillation of diluted DMSO solution into the abdominal cavity at the time of
surgery In this matter, further research is still needed.
Consequently reduced, solves or prevents the DMSO formation
of scar tissue, an advantage is also important in burns. It prevents the
contracture of scar tissue that remains after burns. DMSO was used by Russian
specialists in March 1995 for the local treatment of superficial burns. Dr.
Fil'iula administered the HautPenetranten (DMSO), at young people with burn
injuries among organizations, and conducted a comparative study with other
therapeutic agents combustion: by nitrofurazone, trimecaine, and Monomycin. He
found that DMSO was superior to other agents in the therapeutic action.
Dorothy S. Ludwig, from Lake Grove, Oregon, wrote on March
25, 1980 a letter to the Honorable Claude Pepper, in which they announced the
following: "I used it at various burns, and the pain was immediately
stopped, and somehow prevented DMSO damaging the sharpness of combustion to
further penetrate into the body, and more tissue. No blisters, scarring or
infection. "
As Dr. William Campbell Douglass in Sarasota, Florida,
medical practice, he gained experience with a small, six years year old girl named
Penelope Pappas, from Sarasota, which slid her finger over a prolonged period
of time in a bulb socket. My index finger was at the head white as ash, cooked
and burnt. Within 30 minutes, Dr. Douglas was able to soak the finger in a
strong DMSO solution while the child cried from the pain by electrical
combustion. After 20 minutes immersion in the liquid, the girl stopped crying
because she felt no more discomfort. She slept undisturbed all night, and the
next day a pink and healing index showed the finger --- a truly amazing
character, in view of the seriousness of their injury. At the time of the
accident it was believed that they would eventually lose the tip of her finger
by gangrene. Today you would never be able to see that they had ever suffered an
injury.
^
Antifungal, antibacterial, antiviral action
DMSO stops the spread of fungus. It was found to be
effective when it is combined with the oral antibiotic agent Grisefulvin to
kill ringworm, and especially in myotischen toenails. The solvent can be mixed
with other common antifungal ingredients, such as iodine, or any one of the
commercial preparations, in order to set a 90 percent solution. I recommend
treatments in this way is not, except under the supervision of staff from the
health sector, which should of course all the treatments that are described in
this book durchfühern. Administered in fungicidal toenails, or tinea Pendis, a
paste of grisofulvin and DMSO works well to bring the condition under control.
When I practiced medicine for Podiatric Medicine, this was a treatment method
that I have developed and applied. The solvent transported Numerous fungicides
deep into the skin, which is malignant infected by fungus. In a lower
concentration of 30-40 percent DMSO is bacteriostatic against Pseudomonas,
Staphylococcus aureus, and Escherichia coli. In the concentration of 12.5-25
per cent to inhibit the growth of hochplemorphen bacteria, which are normally
isolated from human tumors, or by the leukemische serum. Within the tumors 27
such organisms are prevented from growing without harming the intact red blood
cells. Many doctors are pleased that the substance is able to make antibiotic
resistant bacteria sensitive to antibiotics again. The addition of penicillin
or streptomycin to DMSO as an inhalant, the resistance of tuberculosis compared
to these antibiotics is avoided to some extent. It also transports antibiotics
to reduce middle ear infections in children. DMSO is synergistically act
together with other drugs to provide a combination therapy against lung
infections, which have been reported by four Russian doctors in 1986th It was
felt to be effective for the treatment of lung abscesses, and the Pneumenie,
when combined with other antibiotics. The solvent alone combats viruses, and
transported another antiviral drug in the tissue, with such infections, such as
fever blisters or painful shingles. It is proved that the DMSO from the surface
proteins of a viral organism dissolves, to leave only the unprotected core left
exposed to the immune system of its host.
^
Muskuskelettale injuries
The first, as well as some of his most amazing effects that
DMSO put on the day, are in the range of muskuskelettalen diseases. Earlier it
underlined Dr.Jacob on the ankle of a colleague on who had suffered an accident,
and soothed by both --- pain and swelling, which later found out that the bone
was broken. The orthopedic surgeon told about this case, that he had never seen
such a serious break with such a small swelling. In another lab employee who
sprained his ankle, the DMSO put out of pain and swelling, and he strode in
good condition from thence. The sport has proven to be the most versatile scope
for medicine - to eliminate bruises, and relieve sprains and strains. DMSO has
been used successfully in 30 professional baseball players in a team, their
loss of time by the injury was only a third of which would have been necessary
with alternative treatments. DMSO is the choicest of treatment, in case of
injuries of the soft tissue.
The agent facilitates the healing of almost all types of
traumatic incidents of muskuskelettalen system. When administered directly
after an injury to the back, it begins with the complete healing. Without DMSO
paralysis can result. This has been demonstrated repeatedly by experiments on dogs.
A clinical review article that was published in August 1988, confirmed that it
is an inorganic compound is in DMSO, (occurring in laboratorial apparatuses) to
catch up with many interesting properties in vitro, including the ability of
oxygen-free radicals. The four authors used the substance to treat a variety of
clinical symptoms, especially muskoskelettales trauma, but they explained that
valid data to prove its effectiveness, would be missing. Their paper, published
in Chlinical Orthopaedics & Related Research, confirmed the pharmacology of
dimethyl sulfoxide, and reported on its effectiveness in post-traumatic
swelling of limbs and ankle stiffness using the model of a rear limb of a
rabbit. The left and right Hintergliedmaß was identical broken in the
laboratory. Then DMSO was applied daily to the skin only a limb of the test
animal. The researchers suggested that the DMSO reduced, occurring after injury
ankle stiffness in both hocks of the test animal by 41 percent, but it had no
effect on joint swelling, compared with control rabbits. Their proposed
mechanism concerning sunken joint stiffness involves trapping oxygen free
radicals and the reduction or stopping of fibroblastischem growth and its
distribution. (A fibroblast is the cellular element that creates the connective
tissue) criticism of the substance came from Roland Weitzner, MD , a
rheumatologist, of Sarasota, in a newspaper article that the DMSO when it is
applied to injuries such Sprunggelenkverstauchungen, could be dangerous,
because the relief of pain would encourage the patient to use the affected
ankle, although he did not do so should. In actual practice, however, this
presented no problem represents. Surprisingly, in the treatment of
muskuskelettalen complaints, as well as other states in the DMSO is
administered topically, the DMSO tolerated when applied below the hip in larger
concentrations than it. Moreover, apparently the DMSO acts effectively above
the hip with the fastest response to problems that affect the face, neck, shoulders,
upper limbs, upper back, and the fuselage. It should be carefully applied there
under the lookout for side effects. The concentration should be reduced if any
side effects occur. Distilled water is the usual liquid in order to mix them
with DMSO to prepare a solution. There are no known contraindications
indicators against mixing some generally acceptable solution or pharmaceuticals
with DMSO. It seems to be compatible with each drug. In addition, the substance
is not deriving solely from trees, they can be made from virtually any organic
basis approximately, and it is probably also present in human beings in a
natural way, even though it has not been identified as such.
^
Cancer
cancer
DMSO is an excellent additive in the metabolic cancer
therapy, since it potentiates the chemotherapy. There are currently 12
different types of tumor cells in the test tube that can be stimulated in the
DMSO to reconvert into normal cells, informed me Dr Jacob with. used in Chile,
Jorge Corneo Garrido, MD, head of the oncology department of the military
hospital, and Oncologist "Lopez Perez" Foundation in Santiago and
Raul Escobar Lagos, head of the Department of Radiotherapy of "Caupolican
Pardo Correra" Institute, the University of Chile , chemotherapeutic
agents, and DMSO of 65 patients with different cancerous areas. All of these
people were diagnosed as incurable, and have undergone previous other
conventional treatments. This DMSO combination of drugs had increased
antiblastic activity (cancer cells to destroy), by the potentierenden and
penetrating properties of DMSO. It reduced the toxic side effects of
cyclophosphamide significantly, the chemotherapy agent used, especially during
prolonged. The doctors told their patients in three different cancer
classifications a: lymphoma, breast cancer, and various cancers. They reported
the following:
Die best results in reaching a clinical improvement was
achieved in the lymphoma group
Der useful effect on the anemia (anemia) patients was
striking, they looked clear, and were more likely to take their habitual
activities again, was just started after the treatment. In addition, there was
a definite relief of pain, and in many cases it was not necessary to give
Morphine.
Es exists a clear synergism of DMSO cyclophosphamide, when
the latter is dissolved in DMSO with amino acids, allowing the use of smaller
Tagesdoden, as well as reducing the total doses of cyclophosphamide allowed
without affecting the therapeutic activity thereby.
Patienten who can not tolerate in saline otherwise
cyclophosphamide, have a good compatibility with the DMSO medication. A cancer
researcher has found a way to normalize the behavior of cancer cells more by he
carried a mitotic "turnaround". Charlotte Friend, M.D.des New Yorkers
Mt. Sinai Hospital, DMSO injected in leukemic mice, and was amazed to discover
that the cancer cells began because of the injected solution to develop normal
cell functions. She watched the 90 percent of the cancer cells began to produce
hemoglobin, which leukkämische cells actually do. The DMSO has brought the
cells in any way to "on-growing". In a paper which was presented at a
meeting at the New York Academy of Sciences, told Dr. Joel Warren and his
Assezoaten the University of Fort Lauderdale, Florida, following with:
"The treatment of human cancer by combinations of oral DMSO and antitumor
agents is feasible and attractive. Because of the potential of toxic problems,
it must be appealing, however, not only by caution, but also by the
circumstances, to obtain the maximum amount of information about the effects of
DMSO. "Based on the research Des Mt.Sinai Hospitals , as well as the
research of the Nova University, William Campbell Douglas, MD, developed a
safe, therapeutic approach for the treatment of malignancy. This is based on
the assertion that the neoplasm (cancer) signs are a chronic metabolic
(metabolism) dysfunction. Therefore, after testing the Blutchemiekalien and
trace elements, the analysis of the diet, and the determination of immune
status, as well as other aspects of physiology, is introduced the
orthomolecular treatment of cancer. The potential toxicity is closely
monitored. The treatment of cancer consists of intravenous injections of
vitamin C, amygdalin, and DMSO. The relief of cancer pain of the patient, as
well as the return of the appetite was impressive. He got a chance to heal
itself through the regeneration of the defenses of his body. The orthomolecular
treatment of cancer is a non-toxic approach that intravenous injections of DMSO
with optimum nutrients and lifestyle changes combined. Dr. Douglas observed
that he had an option to extend the lives of many of these patients; how many
is of course difficult to say. It has been known for half a century that
certain Murine (on mice) and human cancers is to mature into benign tissue
spontaneously. These observations stimulated researchers to attempt to produce
a state of more normal or benign differentiation in cancer cells through the
use of biological substances or chemicals. Polar solvents, including dimethyl
sulfoxide, dimethylformamide, and monomethyl have proved good inducers of
maturation events in murine and human cancer cells. More than that, having
demonstrated different laboratories that polar solutions the growth of human
tumor xenografts inhibit (human tissue transplanted into the tissue of animals)
in nude mice. These inventions resulted in the entry of monomethyl into Phase I
clinical trials in the US, and Europe. In 1984, two researchers published a
significant paper in the Journal of Oncology Chlinical about their preclinical
work with polar solvents such as DMSO, as useful substances in combination with
conventional treatment modalities, for human cancer. The use of agents such as
DMSO can (with abnormal formation of growth or tissue) change neoplastic cells
62 to benign cells, still it can kill tumor cells. (See the researches of Eli
J.Tucker, MD is reported in Chapter 11, on the potent combination of Hematoxylon
and DMSO against cancer) So a conversion is represented by an important
conceptual migration of the regular Zytoxischen chemotherapy. (Treatment using
toxic chemicals). The use of ripening agent therapy should probably be
considered as a vital new tool in the design of cancer treatment protocols. To
determine whether or dimethyl sulfoxide can move the antitumor activity of
cyclophosphamide (CYC) in patients with lung Plattenpithelkarzinomen, 5
researchers worked together in 1981, and treated 14 patients who had the
disease. Patients were administered intravenously 60 minutes infusion on the
third day of treatment, a 5 percent DMSO solution for three days, and 1500mg
CYT. All blood, Liqorflüssigkeiten, and urine samples of patients were
collected to examine the pharmacokinetics (The effect of drugs on human tissue)
of the CYC. The course of the treatment, and testing was repeated every four
weeks. No anti tumors reactions have been observed, but the 24-hour urinary
excretion of CYC, which is a highly toxic anticancer agent, was much lower than
before, the same researchers reported. In 1982 was published in the Journal
Chlinikal Pharmacology and Therapeutics reported by medical researchers in
oncology that 10 patients with spinal tumors, and indwelling vertikularen Save
up to 10 percent Dimethylsulvoxid upstream (intravenously, orally, or both),
and then with 1.25g / m2 CYC were ever treated. All patients also received
anticonvulsant agents, and dexamethasone. The CYC, and the alkylating procedure
in the plasma, and the accompanying vertikulare cerebrospinal fluid were
measured by gas chromatography, and p-nitrobenzyl pyridine samples. CYC stepped
into the cerebrospinal fluid without difficulty, and was slowly lost from her,
as from plasma. In January 1987, a middle-aged man with multiple myeloma a
cancer of the kidney was successfully treated with DMSO, during the course of
replacing his Blutplasmas.32 Just was published in the issue of July 1983 the
British Journal of Dermatology, a report on the successful treatment of skin
cancer in hairless mice using DMSO and an enzyme which is called
methylcholantrene.
^
diabetes
For diabetics, the importance of DMSO moves into the picture
when it comes to the occurrence of diabetic neuropathy, the classic loss of sensory
nerve function, which can be frequently observed in older people with this
disease. In one of four juvenile diabetics who use topical DMSO, a reduction in
demand may take place on insulin, Dr.Jacob informed the American College of
progress in medicine. It tends blood supply support. By expanding the small
blood vessels, especially in the lower limbs The agent should be made part of
presurgical preparations if the surgeon wants to make the blood supply to a
body part of the diabetic again.
^
Nasal sinusitis, tic Douloureaux, headache
Nasal sinusitis, tic Douloureaux, headache
Placed directly into the nostrils, DMSO can blocked sinuses
within a few minutes to open. It accomplishes this through its ability to
permeate all membranes in the body without destroying the integrity of the
membrane, which we have already remarked above. It thus allows a number of
means to pass through the membrane barriers. Sixty patients who were treated by
DMSO with different types of headaches, experienced a marked alleviation. In 35
of these people have been diagnosed that they had a tic Douloureaux,
unintentional repeated contraction of TrigemiusMuskeln in the face, causing
excruciating pain. 17 of the patients had Kopfschschmerzen with cervical
osteoarthritis (arthritis caused by wear and tear in the neck). With 5 people,
the headaches were accompanied by sinuitis. 2 patients had temporary arteritis
accompanied by superficial pain in an artery of the temple. In the last two
patients simple painkillers were ineffective; both received codeine for the
pain in the temporal artery. After a 20ml dose of 50-percentage DMSO was
administered twice a day to the whole forehead and the back of the neck,
disappeared within half an hour of pain in both patients, and did not return
for nearly four hours. They both sat the DMSO treatment continued for a month,
the pressure on the temporal artery is no longer served at the end of which a
trigger mechanism to trigger the pain. These two people Kofschmerzen did not
return for 18 years. It should be stressed, as always, that DMSO does not
represent the complete treatment of temporary arteritis alone. Cortisone must
cooperate with DMSO. Initial results from 30 patients suffering from tic
Douloureaux were similar. The relief of pain lasted indefinitely long,
topically administered in about 3-4 Tage.34 DMSO looked good at tic
Douloureaux, but there was a better outcome if the funds would be injected
directly into the trigger points of spastic muscles. DMSO is unfortunately not
effective in all cases, convulsions. A letter sent to the Kongressauschuss for
aging, dated 11th Aprill 1980 written by Jouce Louise Ratliff of Selah, from
Washigton said in detail: I have read a lot about DMSO, and have it applied,
and saw it was applied. The relief which received my mother through the use of
DMSO, was fantastic. After years full of surgery and drugs (approved), they
turned to DMSO, and within a short time it achieved the relief of all pain. She
tic Douloureaux in which there is no cure, but only pain and suffering. Even
the prescribed approved agents are of little value, especially because of side
effects and possible overdose, and addiction dependence. I personally
administered the DMSO, and saw the relief that she learned. Later, she
administered the DMSO themselves that they needed for their pain, and always
got relief without side effects. Now, without DMSO, and without a place where
they could which herbekommen, it pumps back full drug, and suffering.
^
Skin diseases, ulcers, and herpes
In the form of a spray DMSO was applied to the face lesions
from 152 patients by Lazaro Sehtman, dermatologist of Alvear, and the Jewish
Hospital, and the Central Hospital of the railway, in Buenos Aires, Argentina.
The skin symptoms have been treated by other methods, which showed no effect,
even after the treatment over a quite long period. Besides the pain by
occurrence of burning and severe halitosis, none of the patients experienced
any adverse effects objective or subjective nature. The best and most
spectacular results were recorded, which suffered in people to shingles.
Shingles is a painful inflammation of the sections of the nerves, arising at
the backbone. The disease comes from the same virus that causes chickenpox.
Here 17 patients had relief of symptoms within 48 hours, by only 2 spray
applications per day. A single adverse reaction developed redness, this
remained for 96 hours.
In the issue of New Zealand Medical Journal, November 25,
from 198, was reported by 64 people with herpes zoster who were divided into
two groups. One group was treated by DMSO alone, and the other was 5 percent
idoxuridine (IDU), administered in DMSO. Both translated to their treatments,
within 48 hours, after the appearance of the rash of shingles. In the IDU /
DMSO group was the time interval until the pain improved noticeably shorter
than in the DMSO control group. And compared with the control group, fewer new
vesicles emerged (tiny bubbles) in the three-day subsequent interval in the
active group. These results are consistent with previously published work, and
confirm the usefulness of 5 percent IDU in DMSO (bekannst as Zostrum), in the
treatment of shingles. In four cases of Gnitalherpes, a form of the herpes
simplex, the patients were able to have intercourse within just two days after treatment.
As with most conditions, the DMSO is most effective against genital herpes when
applied early. One hundred percent success was achieved for tinea versicolor, a
form of fungal infection that was treated based on 42 cases by Dr.Sehtman.
Tinea versicolor is usually a recurring problem, it is the longest time
difficult to cure, but not in the patients who were treated with DMSO. Using a
special lamp as a test, a complete recovery within a week was found. In cases
of inflamed or infected toenails, the analgesic and anti-inflammatory effect of
the DMSO sprays began to occur within 24 hours. These 9 patients were
previously already been treated with antibiotics and anti-inflammatory
preparations, without any success. Two people from the Look Mans group Gilbert's
rosaner Pityriasis, of unknown origin, which usually lasts for at least 2
months, and then spontaneously heal by itself, let disappear his lesions within
a week, by spraying the DMSO solution.
For the other 67 people, the victims of serious varicose
veins, the DMSO Spray proved to be highly effective. Many of these patients
underwent venous ligations, resections, skin grafts, and the removal of their
weakened veins. Some had relapses, however, occurred in these, the fastest
healing of skin inflammation, which is connected with the with this disease.
The patient felt a reduction of swelling and pain, and accounts return to
normal operations. People who had difficulty walking, found himself in a
position to return to work, just 7 days after the start of DMSO treatment. A
remarkable and surprising rapid sloughing of varicose vein ulcers occurred in a
shorter time than any other dermatological method, including surgical
intervention, which is often used in this type of disorder, reported Sehtman.36
Des farther reported Rene Miranda Tirado, M.D. Assistant
Professor of nutrients and diets at the medical faculty of the University of
Chile on quickly heal Hautulkerationen the legs, the feet, and the upper limbs,
infected wounds, other skin lesions and burns of first and second degree in
1371 patients. All were given the exclusive therapy by topical application of a
medical DMSO sprays, comparable to that which was used in the cases of
Dr.Sehtman. Three times per week the medicine was sprayed directly onto the lesions
after they were cleaned with sterile water. In Douglas Center, these states
were treated on a daily basis, at least initially, and then three times a week.
Of the 1371 patients who had been treated in the study Tirado, were 95.04
percent as completely healed, and were able to resume their normal activities.
For example, they have been completely cured by daily spray applications of
DMSO over a period of 20 days with chronic diabetic ulcers on the feet and
legs. Some of these ulcers were on the limbs of patients for 15 years. Rapide
healing was held in chronic varicose vein ulcers which have not responded to
traditional treatment methods used by dermatologists for several years
applied time. The pain and discomfort from these burns,
ulcerated lesions, and skin lesions was almost immediately after a few
applications. Some people suffering from intense pain caused by lesions that
were in areas at a distance from the affected part, which had been sprayed with
DMSO, experienced the joyful surprise that this pain disappeared as well.
Second-degree burns on both arms healed completely, without leaving ugly scars.
Chronic ulcers, patients for years tortured, including those of varicose veins
or mycotic infections caused not healed despite hospital treatment over longer
periods, and in different ways, now healed completely. "The DMSO spray did
the work," Dr.Tirado said. "Neither accompanying effects nor unwanted
symptoms were observed during the use of DMSO-sprays", the doctor of the
New York Academy of Sciences reported. "With the exception of a few cases
of deep wounds, where during the first few applications, a more or less intense
pain occurred which were local and of short duration, there was no obstacle,
then proceed with this very effective therapy. In the study Tirando diabetic
perforated ulcers were treated with local DMSO, through spread and spray the
substance. Perforating ulcers represent a major problem in diabetic patients
with peripheral Polyneuropathy (the loss of sensory nerves) represents, for this
there is no specific therapy. In January 1985, has been described in the
Journal of the American Geriatrics Society, that 20 patients were treated with
chronic, resistant, and malignant ulcer perforated by such DMSO applications.
The solution resulted in complete healing of the ulcers induced in 14 patients,
the daily treatment and a treatment period of 4-15 weeks. A partial response
was observed in four other patients, and in the remaining two patients
experienced no effect. A control group with the same number was treated
conventionally. A complete healing of the ulcers occurred in only two of these
control patients. The therapeuteische effect of DMSO results by highest
Warscheinlichkeit from an increase in tissue oxygenation by a combined
mechanism of local vasodilation (expansion of blood vessels), reducing the
accumulation of platelets (clumping of blood platelets), and it reduces oxygen.
(Absorption of supplemental oxygen from the blood). Accidents subcutaneous
extravasation (leakage of a blood vessel in the tissue) of various
antineoplastic agents (agents against tumor growth) are so toxic that they
might provoke skin ulcers, for which there is no simple and effective
treatment. In European Journal of Cancer and Clinical Oncology, was written
that a group of four Onkonologen recommends the following in March 1987:
"Since 1983, we treated all patients in our institution for the
conservation of extravasation through a zytoxisches agent with a combination of
DMSO and alpha-tocopherol , (Vitamin E) during the first 48 hours after the
extravasation has been administered a mixture of 10 percent Alpa tocopherol
acetate and 90 percent DMSO topically. The dressing was changed every 12 hours.
Eight patients with extravasation of Anthracylin and mitomycin (both toxic
anticancer agents) were treated according to this protocol. No skin ulcers,
functional or neuro vasculare impairment, took place in any of these patients.
The only toxic effect, which was observed in this application, was minimal skin
irritation. The combination of DMSO and vitamin E seems to prevent skin ulcers
induced by Anthracyline and Mithomycin. "
^
Cataracts and other eye problems
Cataracts and other eye problems
In ophthalmology DMSO he great success was placed in the
intraocular region of the eye, and it was beneficial in the treatment of
corneal Schwellung.40 An optometrist reported in May 1980. opposite the
American College of Advanced Medicine (ACAM), thus had to use DMSO in the
treatment of cataracts and other eye diseases. "I treated 200 patients
with macular degeneration (deterioration of the macula lutea, an area of the
retina), macular edema (swelling of the macula lutea), and with traumatic
uveitis (inflammation of the pigmented area of the eye) in the last year,
"said the eye specialist." I infused 5mg DMSO, placed in one ml of
normal saline retrobulbär under the capsule of Tenon behind the equator, or
wherever is the area of activity, a. Strictly speaking, when cataracts all we
have to do is to put a drop of DMSO to the eyeball. "Other doctors of ACAM
described instilling one drop of a solution consisting of 25 mg DMSO and 22cc
(cubic centimeter) superoxide dismutase (SOD) was a or twice a day to correct
cataracts and glaucoma (gray and glaucoma). The ophthalmologists shared the following
with: "by the use of DMSO glaucoma drugs are potentiated, including these
that are needed in the treatment of wide-angle glaucoma. However, DMSO alone is
better with macular degeneration. For dropping combining 5 mg of 2cc DMSO with
5mg of 2cc SOD for 4cc solution. The first evidence of the potential efficacy
of DMSO in retinal diseases, variously as deterioration, degeneration,
dystrophy, and abiotrophy designated, all non-inflammatory disorders of the
retina were discovered accidentally. The retina is a part of the eye is
sensitive to light which, a delicate film that covers approximately two-thirds
of the inner eyeball. It is firmly connected to a deeper layer of the choroid.
Some patients with retinitis pigmentosa, a retinal disease that had applied a
DMSO treatment for various diseases muskuskelettale, noted that improved their
vision while taking the average. They told this Robert V. Hill, M.D. Medical
School of the University of Oregon, and he undertook a preliminary study on the
effectiveness of DMSO in the treatment of retinal diseases. "This
investigation was initiated after a patient who suffered from retinal
pigmentosa, a rather spectacular recovery in eyesight experienced after DMSO
treatment." Dr. Hill on the Science Writers Research to Prevent Blindness
conference in Los Angeles in February was started in 1973. at the time, as his
DMSO treatment, the patient could see a gesture with his right eye, and had a
visual acuity of 20/200 (Snellen) in his left eye. Five days later (on 15
February 1972) his eyesight was measured as 20/70 + 1 in the left eye, and he
was able to count fingers at a distance of 5 feet with his right eye. Three
months later, the vision was 20/50 in the left eye. "An additional 50
patients with retinal deterioration (macular degeneration, as well as Retinis
pigmentosa), has subsequently been treated only with DMSO, and the obtained
subjective evidence was seemingly encouraging," continued Dr.Hill. This
subjective evidence consisted of stabilizing or improving their eyesight, the
improved or more stable visual field, as well as the improved night vision. (
"Subjective" because it requires subjective patient response). Of the
50 patients who were treated with DMSO, 22 improved their eyesight, 9 improved
their visual field, and 5 better adapt to the darkness. 2 patients were further
back, and the rest had no measurable changes, or noticed personally not improve
his eyesight.
^
The asthmatic syndrome
In a paper that at the Latin American Congress of Asthma and
Allergies in Santiago, Chile, 1969, there were three medical experts, the
allergist Zoltan Bernath, M.D., the internist Norman Bennett, M.D., and the
lung specialist Ernesto Chacon M.D. their results known about their research in
the treatment of asthmatic syndrome. The medium that was used was DMSO, as
solvents for anti-inflammatory Streoide, and antihistamine preparations with
recognized efficacy, and strong bronchodilators, which
were all administered by intramuscular injections.
The treatment was performed on 153 adult male 84 and female
69, which were divided into two groups. The 43 people in the first group
suffered from recurrent Astmathaanfällen, however, under more or less prolonged
periods asymmetric. The second group of 110 patients had more intensive and
frequently occurring seizures without asymmetric intervals, regardless of the
treatment they received previously.
The results of treatment were evaluated by frequent
inspection of the patient, including her chest sounds, chest movements, exhale
ability vital capacity, as well as other tests. See the Table 4.1 to the extent
to which DMSO solution has helped the patient. Table 4.1 As the DMSO solution
helped the patient
Results number of all patients percentage of people
Excellent 37 24.5
Good 92 60
No change 24 15.5
^
Pregnancy after tubaler obstruction
Thousands of animals were fertilized by sperm that preserves
the substance DMSO was-and had normal offspring. As well as other means, which
should be avoided during pregnancy, it should also not be applied. Anyway,
women who want to conceive a child, found success by DMSO
Hydrotubationsbehandlung. Hugo Venhas, MD, head of the gynecological department
of Valpariso Naval Hospital in Chile, reported that a solution containing one
gram enthältt chloramphenicol, plus the contents of a 5 cc vial DMS with dexamethasone
and Chlorpfeniramin, the whole diluted with 20ml dest.Wasser, was injected
through the method of ascending Hydrotubation through a cannula sterile in the
woman, because of the inflammatory tubalen obstruction. A series of six
Hydrotubationen, one every three days have been performed. was as good tubale
function achieved, the woman was asked to lead a normal sex life. If the
pregnancy is not entered within three months, the treatment in the same form
was repeated. An analysis, based on the results that have been noted by 64
patients have been reported. Dr.Venegans said: "The results that we
received through this new approach have surpassed the traditional methods of
treating infertility tubalen far. Possible limitations of this new method of
treatment are minimal, and observed no unpleasant side effects, except for the
characteristic odor which is exhaled by the patient during the therapy DMSO. Of
the 47 women who were sterile, were 27 pregnant ------ A success rate of 57.4
percent. 12 were given their babies to full maturity, healthy children,
representing 25.5 percent of all. Three women had spontaneous disposals, four
more had voluntary disposals for their own reasons; the remaining seven were
normal pregnant at the time of presentation of Dr.Vegas told the New York
Academy of Sciences in January 1974. It is worth noting that these pregnancies
among women of members of the Chilean Navy occurred that were only for short
periods on land. The gynecologist said, "We are convinced that the
beglückwünschenswerten results that have occurred, not only represent a
temporary improvement."
^
Various applications of DMSO
I could go on with the description of conditions clarified
by DMSO, or were substantially improved. In fact, every body, most physical,
and many mental illnesses, was affected in some, the patient helping nature.
Instead, I want to dedicate the remaining chapters these health problems where
more research has been recorded, and I will present in this section some other
contraptions. In the dental practice in Poland DMSO explained problems with the
gums, and was effective in cases where corruption reached the dental nerve. In
cases of corruption DMSO attacked both on the infection and inflammation by
nursing both, and the pain and the same time. Russian doctors informed in
November December issue of the newspaper Stomatologiia of 1988, such as young
patients and older were successfully treated with DMSO and procaine, to free
them from the chronic parenchymatesen periodontitis. (Inflammation of parotischen
salivary glands) in 1981 was combined in a different Russian study DMSO with
two means to this dry in the treatment alveoli. In a dry socket is a non-healed
wound on the side of a tooth extraction, characterized by intensive
Pain, pus flow out and sequester. It is usually accompanied
Duch a difficult extraction. DMSO acts as a synergistic Penetrant for the two
agents, thereby increasing the rate of healing.
A German study showed that women who DMSO was administered
one month topically, were freed from a painful condition of the breast, chronic
cystic mastitis. States of the urinary tract, which have not been affected by
any known medicine, responded to this drug. In some cases it was possible for
men, again perform sexual intercourse, where early pain or urethral blockage
made this impossible. DMSO accelerate blood flow by increasing the blood
vessels. South African studies show that it is at Herzatacken or angina
pectoris effectively. It is rated to prevent the damage to the heart muscle. It
would be the most urgent need for research on the use of massive doses of DMSO
(2g per kilogram body weight) for the treatment of heart attacks. Only by
soaking the hands and forearms of his patients in the middle, had the former
Rheumatologist the Cleveland Clinic, Arthur L. Scherbel, M.D., great success in
scleroderma, in which thickens the skin becomes hard and rigid. More about the
use of DMSO in scleroderma can be found in Chapter 13 is similar to the past of
the DMSO from ether. Ether has been known for 600 years until it was verwendte
as an anesthetic. Dimethyl waited nearly a hundred years on the bench until it
was discovered that it has medicinal properties. Extensive tests for more
therapeutic applications, to detect possible or unknown side effects, both clinical
studies and laboratory experiments take place every day. Reports of the DMSO
are forwarded daily to the University of Oregon, the central clearing house.
New information and more journals references are sought. What is recognized as
toxicity or side effects, should be compared to the medical community stored
and transmitted, including the FDA.Die following section defines writing is
complete information about side effects and toxicity, and how these with DMSO
are connected. As you will see, there are not many. The research goes on, under
the watchful eye of the FDA.
^
Chapter 5
Chapter 5
The toxicity and adverse effects of DMSO
The ABC-TV program Good Morning America, interviewed Robert
Herschler, the co-discoverer of the pharmaceutical effects of DMSO, on 5
February 1981 at 8:17 AM. The spectators saw this chemist, a former employee of
the Crown Zellerbach Corporation, now director of DMSO research center when he
said the following: "..... the toxicity of DMSO is very low. It is not
true that it is dangerous. Compared with aspirin, DMSO is a much safer drug.
People come to when they take aspirin; nobody ever came
to the application of DMSO "The host of the show, David
Hartman said," about when this is the case, and you are convinced, why has
the FDA its use not permitted "" In 1964, the FDA complained
bitterly.? DMSO, because it is both a commercial solution, as well as a
medicine. "replied Herschler." They could not control it. In
addition, we had a meeting with Francis Kelsey of the FDA, in which she raised
her hands and said: "We can not cooperate easily with a product such as
DMSO. We review hundreds of applications for new registrations that come in,
and we simply have neither the budget nor the staff to do so. "Since they
took a firm stand against the DMSO ......... There are many controlled studies,
who verified that it is effective and safe. And the FDA knows that! The FDA
decreed last over 100 000. Clinical Patient reports if they had evaluates them
statistically, what they have done so if they had tried to examine whether it
is unsafe or effective, they would simply not allowed to do. They used this
maneuver of "double-blind", --- to be able to this
"double-blind" to use as a base to the DMSO to be rejected.
"Herschler added that there is a situation of a" bureaucratic Mickey
Mouse " would that would keep the DMSO from the hands of the people.
Hartmans other television guest, J.Richard crout, M.D., director of the FDA
Division of drugs, it looked at as an exception, to be placed on a level with
the Mickey Mouse. "It is true that there has already been the breath of an
initial investigation already applied --- scientific banter ----- sure many
patients have the DMSO," said Dr.Crout. "There is no question about
it! But it is not "Why not?" Passed through the rigorous,
disciplined, controlled type of development, as well as doing all the other
drugs. "David asked Hartmann. "I think there are probably two main
reasons. The one is that it really has not caught the attention of a number of
experts. It is not dramatically effective, and a number of people have realized
this. Secondly, I think the way of its application tended over the years to
scare the Etablisement science. Unfortunately! A lot of people who are normally
in charge of drug research, and the study of new drugs, DMSO have simply
neglected. "" What proof do you have that it is unhealthy? Do you
think that DMSO is harmful? Mr. Herschler informed us that it would be safer
than aspirin, "said Hartmann. Dr.Crout replied: "It is even really
sure if there are on the skin. I do not think that I would spread alarmist,
would if people apply and use only for a few days. However, anyone who uses it
a month or longer, in doses of one ounce (31.1 grams), or more, is in the range
of the unknown. There is simply not much experience with its Toxiztät.
"The agent is located in the unofficial general use since 1964, applied by
thousands Americans, and so far no Toxiztät was reported by consumer reports,
medical meetings, in the scientific literature, while the four international
symposia DMSO, or even somehow different. The approximately 2 000 people, for
which the physicians have personally prescribed in medical practice, the DMSO
were advised not about any serious health reactions. Yes, there are minor side
effects, which I will discuss, but they are not significant in the many
advantages of the DMSO. If certain toxicity or ill health from its use? No,
absolutely not!
^
Laboratory studies on the toxicity of DMSO
Scientists have studied DMSO at 8 species of mammals, including
human beings, as well as some fish, and birds, with almost universal agreement
on its low Toxizität.1 long- and short-term administrations of many animals,
have shown that this is very well tolerated. When it was fed, injected, or
administered to the skin of laboratory subjects, or human clinical subjects,
about the periods of weeks, months, or years, there was no, or very few signs
of any adverse reaction. People want to offer the analgesic properties that
DMSO. Although mild side effects are present, they are improving the difficulty
that this substance be worth. One of the explanations that Richard J.Crout made
in Good Morning America was that DMSO "would not be dramatically
effective, as well as a number of people would admit that too." What he said
is directly the opposite of the official declarations of Dr.Crouts private
office of the FDA. Published In fact, an assessment that gave the FDA known
about drugs, and in Consumer Report, showed that the authorities often
contradicts itself. The FDA behaves secretive in relation to the type of
studies that are needed to give in order to allow a drug to be used. The
Authority explained to the public that when a drug is safe and effective, it is
also permitted, but this is not always true. For example, a number of drugs was
classified by Dr.Crouts office with respect to their effectiveness. The
classification divides the drugs into the following Kathegorien on: 1A --- This
means is a rupture-like discovery; 2A ----- This agent has potential
applications; 3A ----- this means is useless sometimes. For 37 drugs, the FDA
classified the into these categories, only four were rated 1A. DMSO was one of
those four. So far, the FDA has not approved DMSO for general medical use, and
Dr.Crout also alleged nor, it would not be "dramatically effective."
Since DMSO dissolve many materials, and can be absorbed through the skin, were
combinations of the solvent and many other substances studied. Some materials
which have been dissolved in DMSO showed a change of their toxicity, or speed
of the Absorbation. Many remained unchanged. DMSO only increased their
therapeutic activity.
The toxicity of a substance is in science indexed by the
LD50 value, meant the number of milligrams (mg) of DMSO per kilogram (kg) of
the test animal, which caused the death of half of the animals to which it has
been tested. The observation period normally varies between one and four weeks.
So, 100 Guinea pigs get a DMSO, or several weeks, at a dose of 2mg per kg (one
pound is about 0450 Kg), so that gives a three pound Guinea pig, about 3mg
DMSO. Raising the dose up to a point during that period, at the die half of the
animals from the toxic dose, or the value of LD50. The toxic dose, divided by
the therapeutic dose produces the therapeutic index. This therapeutic index
tells researchers and doctors how dangerous a drug, or a substance in the
living organism is, especially in humans. The higher the number representing
the index teherapeutischen the safer the drug or substance. If there is a
smaller number, the substance is toxic. The LD50 of aspirin in monkeys is 558
mg / kg. The LD50 of DMSO in monkeys 4 000 mg / kg. So to speak, DMSO is seven
times safer than aspirin. In cases laboratory mice were tested which of DMSO,
when it was applied to the skin LD50 has been reported with 50 000mg / kg. Mice
survive immersion in up to 60 owned DMSO completely. Rats survive immersion in
80 owned DMSO, and they survived the repeated immersion in 60 owned DMSO three
times a week, for 26 weeks. See Table 5.1 on the single-dose toxicity of DMSO
and the LD50. In humans, the DMSO concentration on the skin produces a
reddening typically, but the effect is often not longer perceptible after
repeated applications. When people who use the means 35 percent, a burning
event in the area is noted with the contact. Fewer patients experience skin
roughness, mild itching, blistering, skin inflammation, thickening, and
scaling. None of them are toxic reactions, but only side effects. Some of these
effects arise presumably by dehydration, as well as by the removal of oils from
the skin. In most cases, a smell on the breath or on the skin is probably. (See
the detailed description of side effects of DMSO at intravenous use later in
this chapter in itself.)
It could toxicity occur if the agent is inhaled. DMSO
evaporates very slowly because its vapor pressure is 0.6mm / Hg at 77 degrees
Celsius. Therefore, when it is administered to the skin, the DMSO concentration
in the air is usually very low. When heated or sprayed, however, the normal precautions
against inhalation by the user should be taken, as with other organic solvents.
The addition of DMSO to the blood causes different reactions from, resolutely
with its concentration, and the method of administration. The effects of skin
applications of DMSO, the membranes of the small blood vessels of New Zealand
White rabbits are in Table 5.2. shown.
Table 5.1 Single dose toxicity of DMSO and the LD50
Administered species on the skin numb through the mouth in
the blood stream under the skin in the abdominal cavity
Mouse 50 000. 16500-24500 3800-8900 13900-20500 14700-17700
Rat 40000 17400-28300 5200-8100 12000-20500 13 000
Guinea Pig -----> 11 000 ----- -----> 5500
Chicken ----- 14 000 ----- ----- ---- cat
----- ----- ----- 4000 ---- Dog
> 11 000 of> 10 000 2 500 ----- ---- Monkey
> 11000> 4000> 4000 ----- -----
Further studies on live animals have shown that the blood
circulation back soon returning to normal, according to the direct
administration of DMSO in a vein. Dogs recovered after he intravenous injection
of DMSO at a height of 10 000mg / kg rapidly. In the scientific literature
never cases any toxicity that occurred in humans or animals through the skin
application of DMSO have been reported. Tests were conducted on hamsters and
chickens, in which direct injections of DMSO were placed in the embryo or the
area of the fetus, and it came to birth defects. However, 50 owned DMSO,
given orally at a dose of 5 g per kg per day, to male and female rats for 4
days, before mating, caused neither abnormalities nor infertility. The females
DMSO was given during pregnancy, the litters were born normal. DMSO is not
carcinogenic. Further, the composition does not allergic tendencies.
General allergies that already exist in humans, such as this
house dust, animal hair, grass, pollen and are not reinforced by DMSO.
Nevertheless, be warned that the skin irritation that occurs in some people,
(which cause allergies substances) through the medium, the activity of some
allergens could increase.
Administered by any means, DMSO is absorbed and enters
through the skin capillaries in the bloodstream. These tiny blood vessels to
distribute it in the circulatory system, so that it penetrates the tissue of
the body. Most of DMSO is unconverted excreted through the urine, and
laboratory studies on rats and rabbits have shown that 85 percent of the agent
takes this path. Something is oxidized to dimethyl sulfone; while has been
furnished in a study with cats proof that 3 percent of DMSO is excreted in the
breath as dimethyl sulfide. This dimethyl sulphide, a product of the metabolism
of the body is that which gives a DMSO patients the malodorous smell and
breathing. Such metabolized products are non-toxic, in the measurable
quantities that were found in the body. Table 5.2 Effects of DMSO skin
application in New Zealand white rabbits
DMSO concentration in percent Observed Effect
_____________________________________________________________________________________
20 Glue the white blood cells
30 A granular, pasty consistency
50 or more momentary solubilization
the red blood cells, bonding
of white blood cells,
fibrinogen precipitate
_____________________________________________________________________________________
It is noteworthy that the Qwelle halitosis, dimethyl
sulfide, was found from natural sources including milk, boiled corn, tomatoes,
tea, coffee, Asparangus and clams.
^
Ocular changes that brought the spell of the FDA with it
Ocular changes that brought the spell of the FDA with it
The research at the DMSO in the USA came abruptly on
November 11, 1965 to a standstill, since changes of the crystalline lenses were
observed in a number of mammalian species. A conference between the FDA and the
pharmaceutical companies that were involved in the research, has been called
up, and they declared themselves in agreement to suspend the clinical trials.
This set aside, were observed no changes in human beings or primates. A
possible error in the pretreatment examination of a large number of patients
who were at that time in DMSO treatment was that her eyes were not previously
checked routinely. The consequence of the retraction of the DMSO from clinical
trials was that it was offered of extreme toxicity, comparable to that of
thalidomide, or any other means, which had previously fallen into greater
toxicological problems. It was a medical bureaucrat FDA, Dr. Francis Kelsey,
which thereby became famous that they had allegedly held thalidomide from
invading the United States in 1962 under causing birth defects. (At least
that's the official version. The whole truth is that thalidomide was used in
the US for six years, and was available for 1,200 doctors. There were American
thalidomide babies, many of whom were the children of doctors! It is the same
FDA official who threw their hands in the air, an alarm and frustration against
the DMSO, in the years that followed the ban by the test in 1965, as reported
by the chemist Robert Herschler in Good Morning America. declaration, which was
issued on March 24 in 1980 by Steven D, Symms during a hearing before Congress
Committee on aging processes in the house of representatives, pointed to some
of the bureaucratic problems that were shown here to save Congressman Symm said
the following. "I think what we really need is a wide stance, which
affects not only the DMSO, but also other products. we had a problem with
alferatte. we also had the problem with Erythrozin in tuberculosis, it took so
long, it in the US to bring to the market, although in other parts of the
world, people these products already applying Deten very good. Part of it is
due to our überstriktven changes that were adopted 1962nd They certainly have
the cause accrued for a showdown of the ability of the FDA to make these
decisions and enforce them quickly ....... The Fundamental question is, what
happened to the FDA since 1962, when someone busy and I have used a lot of my
time to occupy myself with it, "said Mr.Symms continued," is that we
have a delay of drugs to consider a showdown of effective need to be able to if
something is effective. "As mentioned, there were in 1965, no cases of
confirmed human eye lesions or abnormal symptoms, by any administration to
patients. None of the studies, carried out by any pharmaceutical company
pointed to eye problems. Instead, were changes in the refractive index
(turbidity), found in dogs, rabbits and pigs. After the DMSO was kg overdosed
with approximately 5g / three months, the animals were weak myopic. No
microscopic or chemical differences could be found between the lenses of the
treated and the control animals. The affected animals two zones created by
different light refraction. That could easily be observed by a Optalmoskop, and
using a slit lamp. It happened in relation to the dose, and the problem
disappeared when the dose was reduced. These animals were exposed to doses that
correspond to the 50 or 100 times a normal human therapeutic dose. Until now,
the pretreatment were studies on the eyes of human patients not performed. The
researchers were of the opinion that the review, at this late date, all of
these people who had been treated with DMSO, would be fruitless. Many of the
patients were older, and began their DMSO treatment under pre-existence of eye
problems. Everything the researchers so they could do was to high doses to
check the long-term DMSO patients. In Portland, Oregon, examinierten Dr. Jacob
and Edward E. Rosenbaum, M.D., Clinical Professor of Medicine and Head of the
Department of Rheumtologie Medical School of the University of Oregon, 32
patients by Opthalmologen that were connected to the medical school. These
patients had been treated between three and nine for ten months at an average
dose of 30 grams of DMSO per day. None of them had any of the characteristic
lens changes that have been observed in animals.
One of the 32 patients was a nineteen-year-old man from
Seatle, in which, by changing the procedure a complete pretreatment examination
by a Opthomologen few months was conducted before his injury of the neck. The
neck was treated with 60 grams of DMSO per day, more than 20 months. In his
subsequent eye examination no changes in the lens were observed, even with
careful tonometry, the field of view, the refraction of light, and in the slit-lamp
examination. At the Cleveland Clinic, Dr. Scherbel 44 people in treatment with
Slerodermie. Some patients received as much as 3g / kg body weight a day, and
were treated over a period of 23 months. None of them had the characteristic
changes in the eye lens, which occurred in patients treated with the DMSO
animals. After 11g / kg DMSO was administered to the skin of monkeys, and they
5g / kg each day, was given to drink over the period of one year, were no
changes in the eye lenses. The laboratory staff speculated that the eyes
changes occurred only in dogs, rabbits and pigs. Meanwhile, pharmaceutical
companies began to work to collect case reports in which no real toxicity, or
any kind could be observed it. The Merck gained progressively 17,000 patient reports.
The Syntex collected some 7 000, and E. R. Squibb and Sons in about 3 000. The
FDA seemed to the eye to be concerning these human studies blind, although DMSO
had been officially banished from the human experimental use. Richard D. Borbyn
Thereupon, M.D. of Bainbridge medical center, in Bainbridge, Iceland,
Washington, commissioned as a representative of Squibb 'Laboratories to develop
a program to re-establish the clinical research on DMSO. In the latter half of
1967 to February 1968 Dr Brobyn led by permission of the FDA by human
toxicological studies of dimethyl sulfoxide, especially as it is as I behave
towards the lens.
^
Hoogstraten Lens changes on humans?
65 healthy inmates of the state prison in Vacaville,
California, offered themselves to get administered a 80 owned DMSO gel on their
skin, at a dose of one gram per kilogram of body weight, over a period of 14
days. There were no toxic effects. Next, allow a second group of 40 healthy
prisoners that they covered for 3 months with DMSO, and there were no toxic
result. Her eyes were examined by slit lamp, and Opthalmoskopen Tenometrie;
Your Linsbrechung and visual field were examined, and underwent many of them
blood, urine, liver, and other analyzes. These were cardiovascular studies,
neurological and other physical tests, and Elektrokardische studies. It was the
most extensive series of toxicological studies ever carried out at a time.
Explore Table 5.3 on, is shown in that the DMSO emanating no harm to the human
eye. The conclusion was by Dr. Brobyn: "A very extensive toxicological
study of the DMSO was carried out on the 3-30 times the amount of a normal
treatment dose in humans over a period of three months. DMSO seems to be a very
safe drug for human administration, and in detail, were the lens changes,
Table 5.3 observations prove the harmlessness of DMSO to the
human eye.
Number of human patients duration of DMSO treatment footnote
(in the edition eng.) Unlimited Up to 2 years 31
160 ----- 32
52 9 months 33
9521 ----- 34
38 12 weeks 35
108 Up to 15 months 36
Further studies 37,38,39,40,41
which in some mammalian species occurred, not in men, which
were in this, very high and prolonged treatments. I am very happy to be able to
present this information now so that we can dispel the myth of permanent that
DMSO in any way would be a toxic or dangerous agents. "On the other hand,
the DMSO seems to be effective, it could be legitimately used as a hanger.
Considering the enormous amount of DMSO, the first group of
prisoners, for 2 weeks was long, and the 2nd group for two months, the absence
of toxicity is confirmed. Wog the average subject 90kg (1Kg correspond roughly
2.2 pounds), and used this to 1g / kg, then 8.1kg (8100 grams) were taken, in
the next 90 days of testing. Any other means, whether sugar, salt, coffee, tea
or taken in such immense quantities would kill the subject during this 3-month
period. Or he would suffer from serious metabolic problems. Not so the
prisoners who the DMSO haben.DMSO get through the skin was instilled directly
in the eye, and was used to protect the eyes during freezing. Jack C. De la
Torre, M.D., of the Department of Neurosurgery, Medical School, University of
Miami, and colleagues administered for nine days, 3g 40 owned DMSO per kilogram
body weight in monkeys by intravenous injection. These were monitored before
and after DMSO treatment, over a period of 120 days to determine any kind of
pysiologischen deviations from normality. He found none, either in chemical
testing of urine and serum in cardiovascular and neurological studies, as well
as other extensive health studies of these animals. This inferential, the
animals were sacrificed after 4 months, and pathologists led to the death of
investigations by the organs of monkeys. They found absolutely no pathogenic damage
in the organs of these primates that might be caused by the intake of such high
concentrations of DMSO. Similarly, the time when they were still alive was
recorded, it was as well as in human beings, found no obvious pathogenene
symptoms in monkeys. All ophthalmic and pathhogene studies were performed on
double-blind basis. The other tests, as well Evulationen, which were carried
out by the researchers, were single-blind. The routine tests, such as weighing,
cardiovascular studies, respiratory rate, temperature, fundoscopy, and other
studies have been daily, periodically carried out before and after each
administration by the study. Dr. de la Torre said in conclusion: "Proposal
has no changes in refraction or permeability of the lens or other abnormalities
were noted in any animal, before, during, or 18 weeks after administration of
the drug." This toxicology study, which in the Journal of Toxycology and
Environmental Health in the output 7, was published in March 1981 is available
as an eBook by JC De la Torre, Department of Neurosurgery, (R-35), University
of Miami, Florida, USA 33,101th Scool of Medicine, P.O. Box 07960, Miami,
Florida In other animal studies on the effect of large doses of DMSO to the
eyes, the variations of each species depended. The oral administration of 5-10g
DMSO, per kilogram per day to dogs caused a change of the eye lens after a
treatment period of 9-63 days. would for a 30lb dog 5g / kg / day equivalent to
approximately one-third cup per day. The skin application of 4.4g / kg / day,
in rabbits, as well as 9.0g / kg / day in pigs produced effects, after 90 days
of treatment. Lines of discontinuity were produced, and sometimes the lens
clouded. When the administration of DMSO has been interrupted, disappeared
some, but not all changes. It is true that reports from various investigators
identify a secure change in animal eye effects without the unterschliedlichen
means their analysis seemed appropriate. Something that is not to be dismissed
out of hand, is that the lens changes in animals affect only a few species, and
people are not among these species. The dosage and the number of days before
any change in the animals' eyes is noticeable is shown in Table 5.4. A
researcher read to know that a change in the eyes of monkeys occurred after the
experimental animals with 9.9g / kg / day DMSO over 9 weeks and 3.3g / kg / day
for 14 weeks dosierte.48 Anyway, the scientists who conducted this study
indicated, later stated that the study would be invalid. It appears that the
conspicuousness of the lens changes were difficult to assess because the
monkeys in this study,
Table 5.4 DMSO effect on the eyes of animals.
Level animal time to impact on the eye
5g / kg / day orally Shepherd 9 - 20 Days 49
10g / kg / day oral dog 28 days 50
5.5g / kg / day orally dog 9 days 51
5g / kg / day oral dog 63 days 52
4.4g / kg / day Skin Rabbit 90 days 53
9.0g / kg / day Skin Pig 90 days 54
10g / kg / day orally Hase 7 - 10 Days 55
1g / kg / day Skin Rabbit 11 weeks (low) 56
6g / kg / day orally monkey 11 days, no effect 57
11g / kg / day monkey skin 6 months, no effect 58
0.9,2.7,8g / kg / day
Skin or orally
Monkey 3 months, no effect 59
1, 3, 11 g / kg / day monkey skin 185-200 days, no effect 60
footnote
were previously used for other research purposes, a study of
the drug Phenolphthlein with incwuded. In summary, human and animal studies
that have been carried out carefully by clinicians and laboratories to
determine the toxicity of DMSO showed no negative
Changes in the chemical and physiological parameters. No
major pathogens of ocular changes found in humans, and not a great or
microscopic changes were found in any monkeys. There are few adverse effects
arising from the use of DMSO, but none of them is dangerous. The nasty side effects
seem far less to outweigh the wonderful benefits, which set up, in the case
history of Patricia Mc Clenthan that almost experienced any known side effects,
and still uses DMSO.
^
The undesirable side effects
The undesirable side effects
Patricia McClenathan from Cheektowaga, New York, a 39
year-old housewife, a treatment received by rheumatologists because
spondylitis, more than 6 years. Spondylitis is an inflammation. By an injury or
disease, such as arthritis or tuberculosis, one or more vertebrae of the spine
For Mrs. McClenathan it was a chronic condition of the crippled led to a
certain degree of stiffness of the vertebral joints, as well as to more easily
deformation. Since 1964, she suffered from severe pain and loss of mobility.
They walked through the entire gamut of arthritis agent, wich made it extremely
uncomfortable gastric problems. In addition, she received muscle relaxants,
painkillers and nerve blockers in the area of the spine, in the form of an
ethyl chloride spray, and by injections. The nerve blockers helped more than
half the time, and the painkillers they did over the whole period of time, so
they handled the pain, but you could not do their homework. Ruptured disc
problems emerged later as well, which inflicted their additional back pain, and
they handcuffed for prolonged periods of time in bed. In Aprill 1980 she was
referred to a neurosurgeon who sent because of a laminectomy surgery to the
hospital to the affected vertebrae to remove. She underwent a computerized
Axialtomogramm (CAT scan), and the myelografischen Diagnosikprozeduren.
Unfortunately, the myelogram was wrong with in accordance with what the Chirug
expected, and he could not find the exact point where he thought that there was
a rupture disc blockage in the backbone. That's why the neurosurgeon led the
operation is not carried, and Mrs McClenthan was sent home, and continued to
suffer in agony. Extensive bed rest and painkillers, were the only
Behandlunsschemen that were available for them to maintain the balance in their
lives.
The patient fell into a deep depression. Their hopes were
dashed completely. She thought that the laminectomy would solve all their
problems, but now she was bedridden, felt constant very bad, could not do as a
wife and mother, and realized that the last door to escape, was locked. She was
absolutely immobile and suffered from depression. When her sister, who lived in
Port Charlotte, Florida, Pat McClenathan contacted in June 1980 to explain to
her that DMSO was allowed for legal application in Florida, took the patient
the chance --- the last chance --- -To find a way to relieve their back pain.
She decided that she had nothing to lose if they allowed DMSO trying. She was
afraid to make himself hope, but Mrs. McClenathan was a fighter, and refused to
lifelong pain. She flew from New York to the north from to Florida, and was
taken to Sarasota for DMSO treatment every day from Port Charlotte.
Treatment began on Monday and brought no immediate relief.
On Tuesday, she felt even more stringent pain, which is a well known but
unexplained side effect. She was again fully depressed, and believed their time
and money to waste. The relief from their pain occurred for the first time on
the third day of treatment. "Wednesday night I felt a pain relief," said
Mrs. McClenatan. "I was lying on a couch, as a surprising relief came over
me. That night I tested my relief by repeatedly getting up and sitting down,
and I could this for the first time since the age of 6 do it again without
supporting myself, using my hands. I was excited! I was freed from the pain,
I've lived for years. On the fifth day, the last of my treatment, I had no
pain, even with every move. "The drive did not bring them in difficulty,
as it was at the beginning. Sitting in a car while someone else drove was
always amschwierigsten for them, but not now. Subjecting the intravenous DMSO
therapy did not feel uncomfortable at until the solution dripped a little too
fast in their vein, explained Mrs. McClenathan. You should ask the nurse to
reduce the velocity of the droplets, or wnigstens to get up to do it
themselves. De drip can go faster than in the vein on a hand into the arm vein.
Most of the time she held the hand alongside the thumb. Occasionally the
patient asked for a tray on which they could rest their hand while the
intravenous infusion. Pain remained in her arm, about a month after the
intravenous treatment was completed. The intravenous event was accompanied by
tingling and burning, which subsided quickly when the flow was reduced. She
felt sick, but she learned that eating a good breakfast before they went into
the intravenous treatment, which prevented nausea. Each treatment lasted
between three and four hours to five days. The solution, which was located in
the dropper bottle, consisted of 50 percent DMSO in 500cc dextrose, a sugar
water. Mrs. McClenathan said: "I had a total loss of my appetite while I
took the treatment to complete. I had to force myself to eat a soup itself. I
felt the characteristic sweet taste of DMSO on my tongue, almost coinciding
with the opening of intravenous Tropfs by the nurse. It went really fast --- a
surprise, more than a taste, as if I were a little burp, and a drought was in
my mouth. Even now, when I'm only DMSO on my skin, it is difficult for me to quench
my thirst. Similarly, it promotes the urge to urinate. I was quite confident,
because of the smell I carried with me, "continued the patient." The
smell exuded from my pores on the entire body. I think I could see the
substance almost in my bathwater. The DMSO seemed to have a yellowish tint. I
do not know if I exaggerate it, but my brother made me paranoid about my smell.
I am unsure about my feelings because of the smell, I should, however, return
to Florida for treatment, I would not stay in this house. In 5 days he consumed
about 4 cans of Lysol spray deodorant. When I walked by a room was sprayed. If
I remember, I do not believe that everything was bad, but at the time I was
totally obsessed by the smell of my body and breath, and consequently did not
leave the house in Port Charlotte. When I flew home, I was really worried about
how I smelled. "Mrs. McClenthan described the taste of DMSO as not salty
or garlic-like, and do it some. They said it was the taste of mild heartburn or
breaking, which may be compared with mussels, or oysters or other raw
shellfish. As a general response to intravenous infusions, they experienced
mitlerweile slight diarrhea, every time she applies DMSO if. Through the mouth
or the skin "When I play with it begin at home to administer DMSO, the
diarrhea is worse. My stomach and my gut protest worse than at the time when I
took the arthritis agents. This caused me great discomfort, such as bloating,
heartburn, and stomach cramps. It's what happens when I give it only to the skin.,
"She said. They used veterinarily specified DMSO, at a strength of 99
percent that they diluted to 70 percent, by adding 3 parts of water to 7 parts
solution. This veterinärische DMSO, in full concentration produced no hives on
her skin, as it did in others, although Mrs.McClenathan, redness, irritation
and a rash experienced. Administering veterinärischem DMSO on their backs
caused more burning, a warmer feeling, but less odor in the bottle. When it was
mixed with water, the thermal reaction between the two substances seemed to
bring out the smell with it. The DMSO smell definitely disturbed, at the sexual
Zweisamkeiten with her husband, she said in our interview. And this is the
person who helps his wife about to apply the solution. He is a patient and
tolerant man, she said, but he found it very difficult to remain close to her
body, there was no way, even though they would like to covet. "I felt
rejected," she stood, until they discovered how they could overcome the
problem of body odor. Omitting the DMSO application over a few days allowed,
the McClenathans advance their sexuality. It's a little insight that they are
willing to share with other couples in the same predicament.
DMSO transpires from the skin pores from 24-48 hours. So it
remains for 7 days in the body until it is completely eliminated. When Patricia
McClenathan felt extremely well, and was free of complaints, she stopped with
skin application. "I use the topical DMSO for a period of three or four
days, and then I hear again with countries applications for about 2 weeks.
During autumn 1980, I worked with relative ease, despite the constant changes
in air pressure. Previously, this was the worst time of year for me., "She
said. Patricia McClenthan had agreed to publish this experience report,
including its intimate details to help people who suffer from pain, and are
worried about the side effects of DMSO. She wrote: "Since then I take
DMSO, I am now a normal working person, I was not before, I spent much time in
bed, and got nowhere. I can now make the most normal things, citing the DMSO.
At the moment I do not take painkillers or muscle relaxants (both used it
extensively before), and I think, for this reason, I get along very well with
all. I am talking last physically, menthal, and emotionally much better, and I
owe it to the DMSO. I think that the problems that DMSO has caused by far
against the new life that was given to me, are underweight-life, other than
just to survive under constant pain. Again, thank you!
^
Overcoming malodorous DMSO side effect
Mrs. McClenathan experienced virtually all the unwanted side
effects of the routine use of DMSO. The pharmaceutical, as well as the
veterinärische DMSO has his individual way to highlight body's adverse
reactions, and each person reacts to his individual way. "In all the time
that I have DMSO inkorpuriert as part of my treatment program, I experienced no
serious side effects, except for possible redness, burning and itching of the
skin, when applied topically," said Robert L. Harmon, MD, the medical
director the Mattie Evans alderman Foundation of preventive medicine was a part
of the Desert Holistic Health centerOf Palm Desert, California. Dr.Harmon DMSO
used as the arthritis therapy, over a number of years, "The skin reaction.
Much more noticeable than other in some people. There is no other relationship
that you can create. It is strictly the character of an individual. We did not
come across any toxic reactions when administered intravenously, although we
have given people over 50cc pure DMSO in 500cc Ringers lactate solution in
period of 2 hours. There were no toxic effects, neither immediate nor delayed.,
"Added Dr. Harmon added. "We have administered it, wherever there
were skeletal problems included with joints, muscles, and connective
tissue." The biggest problem of DMSO --- the odor which arises when the
agent intravenously injected, taken orally in juice, or subcutaneously, the
skin is spread, has not yet been completely solved.
The chemist Robert Herschler combined DMSO with a series of
complex substances, including urea, salt, or other substances for topical use.
He reduced the DMSO odor by these complexes by about 75 percent. If intravenous
DMSO was administered to seriously ill or injured in a hospital as the medical
center, connected to the medical school of the University of Oregon, the
endotracheal tube a bewustlosen patient was connected to the wall suction to
stop the smell. Exhaust fans were installed, and usually ran in the hospital
and in treatment rooms by physicians, where DMSO was administered by infusion.
In other instances, oral administration of DMSO could improve their odor when
the patient would be cheese, ice cream, milk and other dairy products eat it.
Raw milk seems to be especially able to reduce the bad breath when drinking it.
Raw milk is the primary beverage of children in Chile. If the Chilean youth is
sent to one of the three known types DMSO, the smell of her body and breath is
less offensive, possibly because of the raw milk in their diet. The US Representative
Robert Duncan, Member of the Congress of the State of Oregon, was consistent
with the fact that the smell is the main problem in the DMSO application.
Congressman Duncan said following the Kongressauschuss for aging: "With
respect regarding my own use, is the most serious side effect, to be threatened
by my wife with divorce because they can not stand the smell. Dr.Jacob had
removed some of the smell, and he clad him with another preparation with
wintergreen fragrance. I asked my wife if her wintergreen scent would not like
it, and if that would not dispel their objections. She said no. Instead of You
smell like the mud flats in Bayonne, New Jersey, when the water is gone, she
said, you smell now as the locker room the garbage men. But this odor problem
is infinitely small compared to the relief that brings the agent. "
This characteristic smell that escapes when the DMSO come
into contact with the water content of the body, is the reason that there has
been no implementation of clinical single or double blind studies that were
sought by the FDA that. The report of the ad hoc Komittees over sulfoxide, a
department of medical science, National Academy of Sciences-National Research
Council, supported by the FDA, contract FDA 70-22, Order number 14, published
in August 1973 came to the same conclusions as the FDA. Just put the report the
reason for the lack of double-blind studies found --- it was the smell. This ad
hoc committee said: "It is currently impossible to find a substance that
is able to mimic both the unique breath odor, and skin irritation of DMSO, they
were in double-blind studies not exist, in which the placebo is not by the
specimens should be identified. In this way was the smell in several ways
stumbling block.
^
The condemnation of other side effects
The condemnation of other side effects
The ad hoc committee was harshly the various other side
effects, as a rationalization for its position against the DMSO. Nevertheless
it secured against any condemnation from, and was even close to it, recommended
that DMSO because of its cost-benefit factor. They said: "DMSO produces
side effects, especially on the skin that most people who have been treated,
and there were sporadic cases, with reasonable confidence, in which DMSO has
led to acute general Utrica (hives) in humans. There is also evidence that DMSO
in some species of laboratory animals at doses much higher than those that have
been considered for people who produced a unique variation of the lens. The
nature of these side effects, the importance of animal data, and the frequency
of adverse reactions alone would not guarantee for the misappropriation of the
drug in clinical circumstances in which there is the promise to save lives, or
where it would be safe effective than the currently available treatment to stop
a disease process, to reduce discomfort or alleviate pain. "the members of
the committee, all trained doctors, or doctors in the Health sciences, examined
the most evidence of toxic effects of DMSO in humans and concluded that the
reports "do not correspond with modern criteria of the origin of the
toxicity and safe medicines." Boshaftigerweise we believe that there is a
reasonable argument, namely, that with the exception of eye effects in animals,
the toxicity of DMSO is very low .. we .......... conclude that the use of DMSO
to treat diseases for which there is no satisfactory treatment, is not
particularly dangerous, and justified the further clinical research on the
agent in the treatment of such diseases is. The members wore before their
advanced suspicion of the animal eye effects and any potential risks to human
beings. They said: "..... by the evidence of eye effects in animals, in
chronic studies the risk with prolonged administration to humans should be
weighed carefully against the expected therapeutic results, but it could if a
proof of effectiveness guaranteed research involving a treatment period of 2
weeks to be made with a low risk of eye effects.
Further research into the DMSO, using modern toxicological
procedures, is of absolute importance to provide a solid basis for judging the
safety of prolonged applications of this drug by patients with minimal medical
supervision and monitoring. Such research on animals, especially monkeys should
include:
eine well-designed and executed study of lenticular
effects in subhuman primate
Die evalution of the potential of DMSO for inducing in
carcinogenic, teratogenic, and mutagenic effects
Studien about the biochemical and metabolic aspects of the
mode of action of DMSO in the animal body
Vergleich of toxicity and skin oraler- administration
"The Subkommittee hopes that additional studies on human exposure and
tolerability of DMSO, through the daily and long-lasting skin application are
performed. In such studies, the attention should be paid not only to the
lenses, but also for signs of toxicity to the body cells, as well as various
organs. "
In the Good Morning America television program of the FDA
Commissioner crout said the following: "These tests are conducted by the
promoters or sponsors of the agent. We are in the position to review the work
that has been done once. Wearing the ball up to half, with respect to the drug,
is what the drug manufacturers normally do. And in fact, some work for the DMSO
was used until now, which is of high quality. We look forward to obtain this
information in a year or so. I believe there would be no major changes in the
coming year, from what you can see now, but (to bring DMSO to the people), the
current loop will subside, and in one or two years we will get the information
that we need. "Michael D.DeLuca, MD, an orthopedic surgeon who offers
services at the company Humble orthopedic Associates, PA Of Humble Texas, wrote
to Congressman Claude Pepper, on May 30, 1980 the following:
Thanks for the kind support they have given the medical
profession in the budget session HR7023 to legalize the DMSO national ....... I
want you to know that I, with a practicing orthopedic surgeon and doctor more
years of practical experience, your troubles guess and beyond the opinion am
that DMSO has a huge benefit, and it should be considered in the treatment of
humans. It is imperative that we are able to prescribe, insofar side effects,
for all practical purposes non-existent. Thanks again for your support, against
this relentless bureaucracy that currently intervenes in this area in the
practice of medicine.
^
Chapter 6
The potent drug for sports injuries
During his final year at the Academy, June Jones wanted to
be a defender for the professional Atlanta Falcons football team, and signed a
contract to play in the big football league after Graduation can. But he hoped
that the team management would it not send him onto the field out to show his
skills. The reason? He could not lift his right arm to throw a football. Jones
suffered from a calcification of the right shoulder of his throwing arm. Some
days he was unable to do anything at all. He could not put on his jacket,
because it gave such a punishment the movement of the arm. He spent sleepless
nights, writhing in a cold sweat, especially if it happened that he turned on
his right side. The calcified bursitis his shoulder threatened his professional
football career to finish before they even started. "Fortunately, I was
using DMSO for ankle sprains and bruises at the high school, but I never
thought about it, apply it on my shoulder," Jones told the
Kongressauschuss for aging of the US House of Representatives. "Without
any kind of a chance I read in a paper about Dr.Jacobs work, and visited them
in order to meet him." Jones is originally from Oregon, but had moved to
Georgia, most people from Oregon consider DMSO as home grown home remedies ----
her special contribution to medical progress. "I was treated with
DMSO" continued Jones continued, "I used it in my senior year, and it
took me relatively painless on the season ........ I thus on, began to use it
on Thursday and Saturday, and I was pain-free for 5-6 hours. So I continued as
six months from July to September. Finally, I thought that maybe I should not
do anything more with my shoulder, and it would go all right. From December until
the beginning of April, I raised no weight, and also threw no football. But my
shoulder worsened again. "I went back down to meet Dr.Jacob, and he
administered me an injection in my shoulder. He told me that if I would use
DMSO for 30 days, the calcification would disappear. And she did! Finally, I
would like to say that I in July without using DMSO continue in a camp went,
painless, and also the X-rays showed no calcification in my shoulder. I had
previously taken cortisone, Butazolidin and all the other things that the team
doctors said they would help my shoulder. They did not. The only thing that
helped me was the DMSO. Without this means, I would not play today. "The
DMSO treatment-related sports ailments such as sprains, serious cuts, acute sprains,
bruises, broken bones, tennis elbow, and a large area of gymnastics injuries,
race or field events, injuries in wrestling , football, basketball, judo,
diving, swimming, weightlifting, skiing, cycling, water polo and fencing were
unscathed by the athletes, their coaches, and the coaches and team members. In
cases of acute trauma, can the pain by rapidly, sometimes even spectacular. The
swelling subsides, and the function is recovered. Coaches and doctors said that
the cure is so spectacular, "that they forced us to leave to urge our
patients exercise great care to avoid further damage to the joint," which
had not yet fully healed.
Chronic ailments, some of which were re-emerge, also reacted
rapidly, with pain relief, reduce the swelling and the function was restored.
DMSO also supports the quick recovery, and the return to use, subsequent to the
immobilization according to fractures. The Institute of Sports Medicine of
Italy made the following points: "The complete absence of unwanted
kollatoraler reactions, easy application, and the few precautions that must be
observed, making DMSO to a medication for a wide range of applications in
medical therapy, and also at a much needed drug in the sport due
Traumathologie. "
^
The healing of sports traumas
Is there any reason for such a dramatic weakening of the
tissue that has been damaged by sports, or other causes, and the trauma
triggers in the body? "Yes," says Dr. Stanely Jacob. DMSO "If
they have the test tube cells that are damaged, by what we call osmotic stress,
and one adds DMSO added to these damaged cells, these cells are revitalized,
rather than die, and return to a normal state." accomplishes this because
as Dr. Jacob explained, "it's currently more than just to ease the pain.
DMSO is not only a substance that reduces pain, inflammation and relieves.
Currently it helps to reduce swelling, and this was demonstrated in good
fundamental, scientific studies. "Garham Reedy, M.D. from Enumclaw,
Washington, the former team doctor of the Oakland Raiders, a professional
soccer team, stressed that his players have benefited significantly from the
routine use of DMSO. It did exactly what Dr.Jacob described. In 70-80 percent
of those to whom it was administered at football injuries, good to excellent
results were noted. The injured player had an immediate reduction of swelling
and pain, and there was consequently a more rapid recovery of the various
injuries. These benefits were noticed by the athletes, by comparing their
current injuries in which they were administered DMSO, with previous violations
of the same nature, which they had drawn up. Equally they compared their own
experiences of injury with the experience of others, with the same types
momentary traumas. Dr. Reedy said, "DMSO at 70 percent concentration, is
an excellent agent which seems to significantly shorten the rehabilitation time
for sports injuries of soft tissue or joint injuries. It also contributes
significantly to the fact that support of us who are active in the field of
sports medicine, private medical, and industrial medicine. "It seems to me
that it is one of our greatest objectives, to bring people back quickly to
their activities." Added the sports physician. "Thus, the primary
significance in the use of DMSO is not only in the relief of pain, but in the
ability, this person to rehabilitate faster. Therefore, it could be in the core
of our nation save millions of dollars in the rehabilitation of industrially
injured patients, in which one might bring them back into the work. "With
injuries by professional football and sports, we are interested in the
rehabilitation period. In the event that we reduce pain and swelling, and the
player, or the person can rehabilitate back to his activity faster, we can
significantly reduce the loss of playing time, the loss of work, and increase
the quality of life.
^
A limb that has been rehabilitated
There are hundreds of human experience reports in the top
basketball league, but a poignant story is what happened to a young pitcher the
Washington Senators Bill Denehy. Denehy was the player of a 9-10 record profit
aufstellte, and at a large Stikeout game in which he starred in his last
appearance. The following spring, he tore a muscle in his shoulder from, and
was sold to the Cleveland Indians. But this deal was perhaps the best thing
that ever happened to Denehy since it brought him with DMSO in connection to
to rehabilitate his shoulder. Denehy was the Washington
Senators by the New York Mets in October 1967 for $ 100 vekauft 000th From the
time after he arrived in Pompano Beach, Florida, the training began in the fall
of 1968, a lot of it was demanded. The Senators have not only passed on its
acquisition, in the business, but they gave him also the jersey number 14 ---
the number that Gil Hodges had worn when players with the Brooklyn Dodgers and
New York Mets, and as a manager the Mets. Denehy had plenty to do. "I
noticed it at the beginning not" said the hand same right-handers with
wavy hair, of Middletown, Connecticut. "I knew that the Mets have a lot
nachrückender young pitcher, and I believed in a club, the Washington, I get to
throw the chance. And I did it for the first time. This spring, I thought I had
so many seasons, as no other pitcher of staff, and I had a really good record.
But then the season was opened, and they forgot me almost. "Denehy threw
only three games this season. Then he was sent to Buffalo to throw in the
international league, where he managed a 9-10 record profits with the 2nd
Division Club. He stayed for 2 years there, and it seemed as if the senator
would call him to start again with the full-time throwing in the big leagues,
when Denehy tore a muscle in his shoulder. While he was treated the damaged
muscle fibers, the Senators sold him to the Cleveland Indians. The sale brought
him to Portland Oregon, where he met with Dr.Jacob who cured his shoulder
problems, using the solution with which the surgeon is so closely linked.
"The doctor asked me something before that DMSO was, and it was
administered on my shoulder. It is a very powerful stuff, and we need to know
how you have to use it. It breaks up the scar tissue injury, and represents the
strength of the muscles recovers, "said Denehy. "Elgin Baylor used it
on his knee, and Jerry Lucas. (These were well-known basketball player) This spring
I gave Jim Borg wage in Puerto Rico "added Denehy added" and he threw
a ten seasons game, threw in his last start. "Lonborg for Boston Socks.
After Denehy began to use DMSO, he was visited by Len Zankie, baseball scout
who earlier drew him to the New Yok Mets. "When I told him that would
rumkommen my arm again, Len had to report this to the Mets." Said Denehy,
"because I have a few days later, a call from the manager John Murphy was
recalled, and he told me that the Mets me would draw back. "Sure enough,
they did well, and 1971 informed Denehy the year to play for the Memphis in
Südliga and the Tidewater in the international league. He had an enviable 10-8
winning record. Under these circumstances, and under pressure from other major
league ball clubs who wanted to acquire Bill Denehy, the Mets made him the
major league roster. "I do not know what my chances are, in this
club," he said. "It is obvious that they have many litters. At the
moment I can only ask if I get a chance. One thing, however, I know. My
shoulder is strong again. In Memphis, Tidewater and Puerto Rico I threw 261
seasons this year, and stroked 208 blows. I could not have done if I had not
been healthy. "Bill Denehy got his chance, and made in the big leagues as
a replacement launcher with. DMSO gave the opportunity to show that his
shoulder muscle was in good shape, and was able to do the work to him. Denehy
threw for the Detroit Tigers over several years. Now he has left the league,
because of age, not because of the shoulder pain. The never searched him home.
And if they do, to Denehy felt sure he could again create that good health of
his shoulder through the DMSO.
^
Professional Sports Team doctors use DMSO
Professional Sports Team doctors use DMSO
During the early months of 1980, asked the US House of
Representatives, the Congress Committee on Ageing, answers in the form of a
survey, by professional sports team doctors. It such questions were asked, such
as:
(1) Have you, or your team coach ever used DMSO, or
prescribed for athletes who look after you?
(2) For what types of symptoms, diseases or conditions you
have the means depending prescribed, or seen, that it was used?
(3) If the funds in your opinion effectively to alleviate
inflammation, pain, or other arthritic symptoms?
(4) Should the United States, do you think the DMSO
legalize, for the treatment of arthritis, and other diseases in humans?
(5) Would you testify these answers before Congress
Committee on Aging? The identification of the responding physicians was
voluntary.
The staff doctors of professional athletic teams responded
to the survey. Of the 39 who were surveyed, with only 7 told that they normally
used the funds for such ailments as inflammation of joints, sprains, swelling,
tendinitis, bursitis, muscle injuries, bruises, and gout. Five other team
physicians said that they have seen that the means for the same complaints was
applied. Ten of the twelve doctors who have applied it, or have seen that it
has been applied, DMSO found to be effective in reducing inflammation, pain, or
other arthritic symptoms. Most physicians who responded to the survey, believes
that further research is warranted and important to verify its safety and
effectiveness before DMSO would be legalized in the US, for the treatment of
arthritis, and other diseases in humans. Were
Below comments are listed by doctors, accompany the teams of
professional athletes:
R. R. From Highland Park, Illinois said: "I
experimented early with DMSO, and the only adverse event was a disastrous
breath." R.C. wrote from Oregon City, Oregon, "As I have already
stated in the answer to your completed survey, I find that, ultimately, no ill
effects had occurred at this time, at least in the topical application of DMSO,
and I personally find it to be effective, as the proprietary Counterirritants
how BEN GAY, and this kind of already available remedies. My principal concern
at the proliferation of DMSO is that some things should be done nationally that
happen locally, I believe that is the reason most serious concerns. I want to
specially attract your attention, about the fact that DMSO is injected, in
treating various ailments, and I think that is premature, and somewhat
adventurous at this time. In any case, I believe that if DMSO is generally
available to the population, this should done in a very regulated manner and
are limited at this time alone to topical application. "D.A. From Atlanta
said: "If relevant studies could be carried out to see whether there is
objective evidence of the effectiveness of the agent, then I would prefer to
use." EM from Baltimore stated: "Controlled studies by approved
researchers were and be executed. I would suggest that you consult these
people. The FDA should guide you here. If Congress FDA neither familiar nor
relies on it, this should improve the FDA.
E. V. of Philadelphia wrote: "There is enough anecdotal
information suggest that this is an effective means, so I think that proper
scientific studies should be carried out. I would not use an agent until it has
been evaluated. Y.C. From Houston said, "When used judiciously, it can be
a very helpful and useful tool to alleviate short and long term joint symptoms
and pain." The summary of the survey that was sent to the doctors of
sports teams, recommended the committee members the Komitteeausschuss for aging
as follows: "the Committee was informed of the apparently widespread
Fußanwendungen of DMSO in professional athletes. The team doctors were,
however, reluctant to interact with'dem Committee. Only 20 of the 110 sports
team physicians responded to our, carried out in January survey. Three of them
pleaded for the use of DMSO, just stressed 8 of doctors that DMSO would be
effective to reduce pain or inflammation. "Lowel Scott Weil, DPM, of Des
Plaines, Illinois, the professor of podreatischen Orthopaedics at the
University of podreatische medicine of Illinos is, and the founder of the
Sports medical Centre of the University, and the Sportpodeatrist the Chicago
Bears football team, and the gymnastics team of the United States, DMSO used on
a regular basis, with athletes who are injured. He administered the solution
for over 20 years. One of the classical areas that are treated, is gymnastics.
"I say classic because I spent three full days with the young people, at
the Olympic trials in 1980, in which I applied DMSO every minute, and could see
exactly how their symptoms disappeared.," Said Dr. Weil. "We had a
special gymnast who suffered from a serious Gelenksverstauchung. Your coach
thought it would be no chance that they would be able to participate in the
test, and was going to have them removed. I used the DMSO in combination with
some other physical therapy modalities, and she continued, and even made it
into the Olympic team. "Most of my experience with DMSO I got through use
in tendonitis, myositis (muscle inflammation by complaints), post-traumatic
injuries such as muscle strains, joint sprains, congestion, and water in the
soft tissue. These types of problems tend to have successfully responded to
DMSO. Additionally, I have it still, especially where used for my arthritic
patients with rheumatoid arthritis, and befell them dramatic relief. "In
the patients whom I administered DMSO, I had a success rate of about 60
percent. The Fehelerquote of 40 percent, was in people who had simply no good
or bad effects of the agent. "Dr. Weil" The only side effects were
some skin irritation, as well as the occurrence of an inflammatory blistering,
in people with sensitive skin. Skin problems can be easily treated by applying
a cortisone cream, and seem to be a big problem. I have noticed no other types
of allergic reactions, or disease effects. "The shapes of the DMSO which
Dr. Weil administered topically, were of veterinärischem purity ,, processed
into a 80-percentage gel, and the means Rhimso-50-percentage of 50
pharmaceutical grade , which is normally administered anywhere in interstitaler
Zysitis. Inflammatory disorders such as nerve impulses in feet, were those in
which he found that it worked best. When a football player the Chicago Bears,
the muscle tear in his thigh, it was expected that he would be set for 5 weeks
out of action. "I used the DMSO with him every day," said Dr. Weil.
"For about half an hour I rubbed it on the injured area. Then I
administered it to him before bedtime, and he kept it all after it. After six
or seven treatments, the player felt that he would have complete freedom of
movement, virtually no pain at all, and that he could stretch out his foot as
he wanted. He returned shortly thereafter immediately return to football games.
Apply the players it on your own back? "Not only have I gained experience
with the use of this remedy in my athletic efforts", June Jones said,
"I was even emotionally involved with him ..... I've seen amazing results
in humans. Recently I met a person who was unable to walk for almost six years.
He moved his toes for almost 8 years no longer. To alleviate the pain he gave
DMSO on his spine, not in the assumption that it would cause something else ---
and he can now walk again two weeks after its use. Jones explained that the
DMSO is used extensively as a remedy and for alleviating pain, among sports
personalities, and a number of athletic teams, but not in football. Do not
allow the knowledge that is normally distributed, except for himself, since the
use of the product caused in every way with the professional athletes frown.
Drugs could a player an unfair advantage, the contrived opinion. The Atlanta
Falcons running back, and Haskel Stan Back sprained his ankle in the first game
in which he was ultimately become the starting player. In 1978, he worked hard
in training camp, and was called throughout the season as "first string
tailback". It what his big chance. In the third quarter of his first game
between the Falcons and the Houston Oilers, Stan Back struck a bone, and tore
the ligaments in his ankle. The team doctors decided that he should wear a
plaster cast for the next six weeks and the player has been placed on the list
of injured reserve. With the knowledge of the consequences of a plaster cast on
his wrist, realized Stan back that he could finish with this season. His last
hope vanished. It would again take 4 to 5 weeks after the cast would be taken
back from his foot to his feet again would be good enough to prove himself on
the field. The season would be over before he could make a Single Step running.
The team manager told him to take his equipment back home. His heart was
broken. There would be no more football for giving Stan Back. Then came June
Jones to his rescue. "I tell you, take this stuff home with you, and you
do it all night on it. I will sags, get every hour on, and give to it. He made
it all night, "said Jones. He arrived on Monday without swelling of his
joint. The doctor could not believe it. They X-rayed him again. The bone chips
was still there. It still looked like as if damage had been done. "The
Falcons had on Tuesday free. No game, and no training. The doctors said they
would have to wait until Wednesday to see what will happen with Stan Backs
ankle before they would make a decision whether he can play. Stan baking was
all day Monday DMSO on his foot, and his leg, and all day Tuesday. He appeared
for training on Wednesday and was to run in a position to tackle a football and
throw, and do all the other things that have been demanded by a professional
Fusballspieler. He showed that, on the following Saturday, against the Los
Angeles Rams. "Aviale capability in our business is the most important
thing for an athlete," said Jones. "If you get hurt in a training
camp, can your income, your life, everything that gets your income upright, be
extinguished only by an injury." He said that the DMSO "the time to
get it back to work after a injury creates, enhances or shortened. "When
he was a doctor for the Oakland Riders, administered Dr.Garham Reedy, 70 owned
DMSO with which he began the injury of his players, on an experimental basis,
in October 1971. He explained each patient carefully the side effects such as
bad breath, and possible skin irritations within 72 hours after its administration.
Our technique for administration was to apply it free over the entire joint, or
muscle, "he said," and to let it dry for 5 minutes. This procedure
was repeated up to four times. These treatments we performed two to four times
through the day, across a period of three to four days. "Regular players
come to the hospital because of her serious acute joint or muscle problems. You
are immobilized, ice, and highly placed, for periods of 48 hours while the DMSO
is administered in the manner in which it was prescribed. Viewed over a period
of five years, the DMSO was administered approximately twenty to thirty times
per year. "Said Dr. Reedy. "Some of the players who used the agent,
were Ben Davidson, Tom Keating, Daryle Lamonica, Fred Belitnikoff, Jim Otto,
and Bobby Moore. The greatest value of the medium was in its administration in
the first three or four days of acute injury to a muscle or joint, which had a
severe swelling. Our experience was a significant reduction of 70-80 percent of
the time, with such injuries. "The circumstances of the most dramatic
decrease of symptoms of a sports injury, reported on the Dr.Reedy, was the
serious bruise an elbow, the Bobby Moore had contracted , in a crash during a
football game. Immediately after the game ended, the doctor DMSO daubed on
Moores bruise, and to the whole area of the elbow. Practically after the
solution was applied, saw the doctor and patient, as the swelling went down.
Robert Rosenfeld, M.D., the orthopedist the Falcons had noticed this phenomenon
and viewed with. The reduction of pain happens just as quickly, so that the
primary benefit from the experience of the players, the DMSO, a rapid decrease
in swelling of the muscle or joint is under the guidance of a physician, or to
use it himself, accompanied by a lessening of pain. If swelling and pain
disappeared after a few days, the doctor may speed up the rehabilitation of the
injured member, by the introduction of other heroic measures. The estimate of
the benefit for the players is approximately 50-75 percent by faster results,
and return to the football field, compared to their previous treatment for
injuries.
^
Double-blind studies in sports
Double-blind studies in sports
Double-Blind, or placebo-controlled studies were performed
in order to know the true characteristics of DMSO for sports injuries. For
example, the use of DMSO was in 1981 tested with tennis elbow and tendinitis of
the shoulder joint, by such a double-blind study. Within the period of one
year, treated the sports physicians E.C.Precy, and J.D. Carson, 102 patients
with a clinical diagnosis of either medial or laterialer epicondylitis (tennis
elbow), or tendinitis of the shoulder, by the topical application of dimethyl
sulfoxide, or a placebo. Your controlled double-blind study was carried out
with these patients in private practice of an orthopedic surgeon to find out
how well would treat DMSO these known clinical symptoms. The result of this
study showed that DMSO pain, tenderness, and swelling improved, and the freedom
of movement increased. 40 patients were treated by each of the two types;
Patients treated with the 70-percentage aqueous solution
of DMSO were treated, reached no further advantage by the
middle, as the patient, the 5 percent aqueous DMSO received a placebo solution.
Dr. Reedy tried the double-blind studies run among the players, but was this as
absolutely worthless, because of the special properties of DMSO. He gave a
10-percentage solution than placebo, but the effect was much less bad breath,
only a minimal redness of the treated area, and a much shorter drying time than
is normally at a 70 percent solution. Dr. Reedy said, "We had a player,
Fred Belitnikoff, a round Schulte joint contusion drew upon in a collision. 70
percent were administered at the joint, and only 10 percent at the shoulder. He
said very quickly to me, "Doctor, this is not the right stuff; it is not
red, and it dries too quickly "Therefore, the double-blind studies could
not be completed."
^
The players see a need for DMSO
Dr Reedy noticed with blond players, and this, skin
reactions were more likely to occur with fair complexion, than in those with
darker color. But the degree of skin reaction was not comparable to the
advantages, for example the reduced swelling. He administered DMSO usually in
acute swelling in a joint or muscle trauma of, especially the limbs, or ankles,
elbows, hands or wrists. The unwanted negative effects that he was able to
confirm are the same as have already been described: bad oysters smell that
does not respond to a number of breath fresheners, and local skin reactions.
The skin irritation appear to occur in two separate shafts, normally the third
or fourth day, or in the ninth to the sixteenth treatment session. In blond and
slightly hairy players these phenomena came a little earlier. Anyway, these
symptoms usually disappear within 72 hours, after the last treatment session.
"I also want to tell yet, that the positive effects of many of the players
were desirable in order to get faster on the field back," said Dr. Reedy ,
16 years ago Dr.Reedy ended his association with the Oakland
Riders when he moved into his current home in Enumclaw. Active involved in
clinical practice, and in educating the public in preventive health care, and
against drug abuse, used Dr.Reedy DMSO continue as a tool. "My experience
in my private practice, outside the area of sports medicine was essential not
primarily, then decided I apply it within the sports medicine, since I am with
Dr. Jacob decided. I would say, however, because I would love to apply it in my
patients with Arhritis and acute ankle injuries, as about 50 percent of my
experience in the field of Sprtmedizin originate. Therefore, I am very eager to
apply it more extensively. Daryle Lamonica, a former player of the Oakland Riders,
from Walnut Creek, California, wrote on 2 Aprill 1980 at Val Hallamendaris, the
consul, the Commission for aging,
House of Representatives following:
I am writing to share my feelings that I got through the
experience with DMSO. As a former professional athlete, I had the opportunity
to use it in case of injuries. The first time I had jammed my thumb my throwing
hand. The swelling was so strong that I could not bend it. DMSO was applied,
and to my surprise, the swelling started to decrease within minutes. Although
my skin made currently blowing, I threw the ball within three days hard again,
and was again completely successfully on the following Sunday afternoon. In my
opinion, that would have been impossible without the profit from this
ungebräuchlichem means. I also had other injuries, in which DMSO was used and
the results were very positive. It was administered by my over anstrengtes left
knee, my lower back, my bruised little finger of my throwing hand, and on the
inflamed and sensitive right elbow. I want to emphasize that we are an
excellent team physician, Dr. Garham Reedy had. I relied on his medical advice,
and guidance, and am of the opinion that he was most helpful with my
outstanding accuracy in N.F.L. , He introduced me to the DMSO. I have played
with many other players who have used the DMSO under great success. The only
gripe I have observed is that my wife said about it: "blatant body
odor". This added to my social life is not much towards, but I believe
that this has been improved.
I personally am of the opinion that there is a great need
for the DMSO, not only for professional and amateur athletes, but for all
people who suffer from pain. Therefore, our community is blessed to have such
as DMSO, to help us with calamities.
^
Chapter 7
Arthritis treatment with DMSO and diet
A member of the US duty, Roger O. Varga, from Bowie,
Maryland, the divorce papers were served by his wife. The kind of man was so
troublesome to come by the inability of his arthritic pain out, "that it
could not stand my wife with me." He was a. Mr Varga was a long-time
injured by rheumatoid arthritis, and rheumatoid spondylitis (spine arthritis).
His joints were much worse. In the last five years, up to the point where he
could no longer bear the daily stress After he got an intravenous DMSO anti
arthritis therapy, found Varga, now 59, amazing relief, within less than 5
days. He was able to return to his normal work routine. The patient underwent
two separate intravenous DMSO meetings, within 14 months, and as he traveled home
both times he felt really comfortable. He treated himself currently between
intravenous DMSO sessions themselves, with topical DMSO in the form of an
ointment-DMSO, mixed with a cold cream in 70 percent concentration.
XXXXXXX
An expert who bred beautiful orchids, and is living in Mount
Airy, North Carolina, Calvin Clayton Veron, suffered from a combination of
rheumatoid arthritis and osteoarthritis, which related mainly to his back,
shoulders, hips, and right ankle. Since he received oral, topical and intravenous
DMSO treatments found Mr.Veron who just crossed the age of 72 that his joint
pains had subsided great. He could go better, had less swelling around the
ankle, and increased his mobility in all joints. The patient's condition was
classified as "significantly improved" by the doctor who accompanied
the conclusion of the five-day standard treatment program. Vernon said: "I
brought some home with DMSO to make it continue to oral and topical use. I
suppose it will continue, and I think that I can continue with my work. "
XXXXXXX
A quality inspector, James S. Smith, of Marietta, Ohio, got
the rheumatoid arthritis in November 1979. It was a serious, acute outbreak in
all his joints, especially in the ankles, feet, wrists, and fingers. He slept,
if at all bad, through this deep, sharp pain, which kept him away from his work
also, because of the lack of strength in his arm, and his unstable legs. Five
days intravenous DMSO treatment combined with the administration of DMSO on its
skin, as well as administration by mouth, brought instant relief. The pain
disappeared in so extensive an extent that Smith said: "I'm looking
forward to playing golf."
XXXXXXX
A car mechanic, James E. Singletary, from Porter, Texas,
suffered from rheumatoid arthritis all his joints, for over 30 years. He took
so large quantities of many different drugs. In June 1990, Mr. Singeltary took
five days of intravenous DMSO treatment to complete, and came up with an amount
of the agent home, for oral and topical further processing. He said: "A
month after I got DMSO intravenously and orally, seemed the pain, swelling, as
well as to ease the inflammation, although the soreness persists in my
joints." The freedom of movement of both shoulders widened, and the pain
left his knees and feet.
XXXXXXX
A retired housewife Vilma F. Singer country from Sarasota,
Florida, got a gastritisches ulcer, by taking Indocin, against their rheumatoid
arthritis. Since 1978, it bestowed its knees, hips, neck, and back pain severe.
She underwent an intravenous DMSO therapy, in September 1972, when she had
unusually severe pain, and combined this with oral and topical DMSO, and
combined the DMSO with Xylocnine which it was injected into both knees. This
joint injections brought forth an excellent result. Your grip strength improved
dramatically, and neck pain disappeared. Mrs. Singer Country said: "I am
of the opinion that it is very useful in some areas. Especially in the field of
sacral joints around the waist. "
XXXXXXX
A saleswoman in a clothing store, Beatrice L.Luke from
Saluda, Soth Carolina, suffered Ostheoarthritis in the spine, and in his hands.
You could not stand the various arthritis medications, and found the DMSO
treatment as an alternative. Mrs. Luke learned great results by the intravenous
and oral DMSO treatment, and was able to return to full employment in August
1992nd "My main problem was the pain in my back," she said, "and
it is now much better." They administered 30 times topical DMSO before
they underwent a total pain in the back, but the well-being was gratefully
received after it arrived.
XXXXXXX
A housewife from Port Carlotte, Florida, Mary Hayes had
osteoarthritis, caused for 2 years pain in her arms and shoulders. She was
restricted in their freedom of movement, and could not even put on her bra.
"My left arm was inflamed and swollen, and very painful," she wrote
recently, "It was so painful that I could not find good night's sleep
difficult. After using a can DMSO cream, I can even put my bra back. "Mrs.
Hayes needed any treatment other than their own administration of DMSO on their
skin.
XXXXXXX
A highway toll collectors, from Florida, Fred Flechsing of
Fort Lauderdale, was harassed. By severe, degenerative arthritis of the hips
and knees By the car fumes inhaled at work, suffering Mr. Flechsing also to
lead poisoning, which has possibly contributed to his bad joints. During the
lead level is a durchnittlichen Americans of 0.1-2.0, the hair analysis of this
man gave a work-related lead content of 5.0. Flechsing did not require
intravenous DMSO treatment to
To find relief from his arthritis, as well as always. He
learned this immediately by the twice daily application of a DMSO cream on his
joints, as well as through the regular drinking of oral preparation, starting
on 22 May 1990 levels.
XXXXXXX
A teacher, Marie G.Miller from Randolpf, New Jersey,
osteoarthritis had for over 20 years to endure. She had pain in several joints,
which she needed for her very active life, and for their tendency to do too
much on the day. They needed help to walk, leaning on walls, and furniture in
her apartment from. Mrs Miller writes: "I went to DMSO treatment, as a
last resort to constant pain in all joints, shoulders, spine, fingers toes,
ankles, and knees to relieve. The knees and feet bestowed me big problems. I
could not go without a lot of pain, and it was very difficult for me to get up
from a chair without hanging onto something that was located just near to pull
me from or supporting it. "I got golden shots, Indocin, Butazolidin, etc,
for two years. I took two aspirin (650mg), four times a day, what brought me
some relief, but I had at least as many bad days where I had to be a half or a
whole day in bed, under a blanket, even in mid-summer and at temperatures of
80Grad Fahrenheit or above. "Then I started with Darvon, which gave me
more relief after I 2 tablets, took a day at intervals of 4 hours, while a bad
day full of pain. After I got intravenous DMSO in May 1990, I had only about
taking to January 1991, a dozen Darvon. "Until now I use DMSO for all
joints when they are a bit sore or inflamed. I can stretch out my fingers
straight, without all these previous pain. The joints are a little stiff, but I
am able to use it without pain, as long as I'm careful not to overexert. I was
very happy about the results that could be obtained with the DMSO treatment. I
thank God for every day since I found to DMSO, and the doctors discovered this
treatment, and for the doctors who use it to get it in arthritis to try and
help, "wrote Mrs.Miller.
^
The incidence of arthritis
In a spring edition of the Medical World News from 1991 it
was reported that up to now seven DMSO clinics were opened in Mexico to treat
arthritis patients, mostly Americans. A businessman in Mexico was said to have
treated with DMSO in 1989, 30,000 Americans with arthritic symptoms, with a
turnover of over $ 20 million. Rudy Minoot, owner of a DMSO clinic in Tijuana,
Mexico, told the audience at the meeting of the national 26.jährlichen Health
Organization, in Long Beach, California, on January 18, 1981 exactly how he
uses American institutions to his Mexican clinic fill with US patients.
"We thought of a hospital near San Diego. Patients sleep, eat, and drink
in San Diego. Then we got it in the afternoon, for 2 hours in a limousine to
Tijuana, to deliver them to the intravenous drip DMSO. It is an ambulatory
system., "Said Minoot. "We have a different hospital, 400 miles down,
on the west coast of Mexico." The Mexico Connection delivered
intravenously pharmaceutical DMSO to approximate treatment costs of $ 800 for
the 3-day treatment. People paid their own room and board. This is big business
for the clinic owners, the Americans seem to be extremely vulnerable, facing a
Arthritis form with excessively painful manifestations. Rheumatoid arthritis affects
6.5 million US citizens, of whom 65 percent are women. Ultimately, 66 percent
of those affected are older. Alone in Ohio, suffering 300 000. People only on
these complaints, the Ohio, the annual cost for the State of Ohio declared
Congresswoman Mary Rose Onkar, a member of the Congress Committee on aging
processes. "Because of the arthritic disease estimated to be approximately
$ 450 million excluding $ 175 million wage losses. Furthermore, "said Ms.
Oakar," there is in northeast Ohio, a ratio of a rheumatologist to 200 000
people. "With a total population of about 10 million people, which results
in Ohio a disproportion 5 000 practicing Arthritis specialists. It is not only
the patients with rheumatoid arthritis; there are plenty of other arthritis types,
to keep them busy. All other forms of arthritis together that affect our
national population, add up to more than 41 600 people 000Opfern having
arthritic symptoms severe enough to receive medical attention. It relates to a
six people; Among people over 65 years, it is one of deuces. Almost 4 000 000
arthritic Americans suffer from degrees between complete or partial disability.
Arthritic diseases include 100 species, and osteoarthritis, in which the joints
are worn out and destroyed, makes the most of them. In fact, arthritis is a
common disease. If you live long enough, you will probably also get some form
of complaint. If you are lucky, you will not suffer from acute pain or
deformity, as did the people who I described to you, but you will know to have
it. Arthritis is one of the degenerative diseases that are generally listed,
"that they have no known cause, and that there is no known cure." It
has a long course of disease, and weakened and disabled patients. The prominent
orthodox treatment for the problem involves the use of anti-inflammatory
agents, such as cortical steroids, gold injections, as well as analgesics to
reduce the pain. Aspirin is often used for arthritis. In the history of Western
humanity the irrational behavior of politicians and high-ranking military has
often been attributed to the pain and suffering caused by arthritis. A form of
arthritis drove a Roman general to suicide, forced Henry the VI to postpone his
wedding date, and made it Charlemagne and Alexander the Great, difficult to
live with. It was also the reason for Goethe`s hopelessness.
Joanna Jackson, from Savannah, Georgia, lost all hope, as it
was plagued by the general destruction of their joints, from which severe
deformities and swelling arisen. At 29, she had already almost 20 years when
the disease periodically flared experienced repeatedly, causing progressive and
permanent tissue damage left behind. Because of their rheumatoid arthritis,
Mrs. Jackson had already taken every conceivable arthritis treatment claim that
offered by modern medicine. For weeks she swallowed thirteen, seventeen,
twenty, and even aspirin tablets a day until they got peptic ulcers, mild
deafness, and tinnitus. She took Indocin, occurred to various side effects in
the central nervous system, such as headache, disturbance in attention, as well
as weak motor coordination, which precluded continued use of this drug.
Injections with gold worked only when there was their disease in the earliest,
active stages. Steroids proved generally considered toxic, and began her
features to a moon face transform. Even the means Tolectin, a non-steroidal and
anti-inflammatory therapy brought abdominal pain and discomfort, and even
nausea and vomiting, and it delighted with peptic ulcers. Mrs Jackson admitted
that she thought to end their Miserie suicide until the 60 minute television
documentary on Sunday evening on the DMSO watched. Friends of Johanna Jackson
persuaded them to cross the border from Georgia to Florida, and there to begin
the DMSO treatment. She shrugged respect of which prompt, in the belief that
the prescribed analgesic property in arthritis, the agent, in turn, would be
another quack cure that would produce additional side effects to make their
lives even more unbearable than it already is now.
^
The official position of the Arthritis Foundation
The official position of the Arthritis Foundation
Ultimately Miss Jackson was influenced by the position of
the Arthritis Foundation against DMDO. Previous observations have shown that
the Committee was untested remedies against the legalization of the drug in the
state of Florida, which brought the Arthritis Foundation in the position,
opposition to the use of DMSO to relieve arthritis to afford in Florida.
Charles C.Bennett, vice president of public and professional
education, the Arthritis Foundation of Atlanta, Georgia, appeared before the
House of Representatives and the Congress Committee on Aging. Mr. Bennet said:
"The Arthritis Foundation is not against the DMSO. We would be pleased if
it would be established by appropriate scientific procedures that prove its
effectiveness. I do not think that the security issue is the most important
thing. This has been well understood. But the question of the effectiveness in
arthritis, particularly in inflammatory arthritis, especially in chronic arthritis,
has not yet been clearly resolved. The question is to find an agent that deals
with the problem of pain in a disease, including the search for something that
is not only for a short period, but also in a long-lasting, chronic use.
"Thus, the Arthritis changed Foundation your position. After the
disapproval of the legislation in
1977 to allow the use of DMSO by individual states, and
under acceptance of the ad hoc committee on dimethyl sulfoxide of the National
Academy of Sciences, and knowing about the negative report of the National
Research Council, it approved the Arthritis Foundation for the limited use as a
pain reliever. "No one believes that DMSO is a worthless drug," said
Bennett. "It appears to act as a local analgesic, and therefore it could be
in a lot of discomfort, causing pain, useful. However, there is no scientific
certainty that there swelling, and inflammation is reduced (which is of very
great importance would be used for treating rheumatoid arthritis, for example),
or that the course of deeper changes any connective tissue disease. "In
summary, the Arthritis told Foundation the people who were suffering from
rheumatoid or inflammatory arthritis that DMSO is not the means for them would.
You need more than just pain relief; its ignition must be gedämft, something
even like aspirin in ordinary doses could do this, DMSO could not, they said.
The staff of the Foundation wanted the FDA, DMSO for lower
pain problems allowed to be seen -without time-consuming studies that would be
necessary to clarify questions about the utility of the agent in serious
systemic problems, Bennett said. He had announced that his organization would
have a neutral stand. He talked ambiguous. The TV presentation of Mike Wallace
changed the mindset of Miss Jackson on the mobilization of the treatment, the
official position of the Arthritis Foundation she did not care. About a week
after the first show, she called to consult a doctor who prescribed DMSO. She
arranged her journey, and borrowed the money to pay for the treatment. The
average were in the US for the entire process of DMSO arthritis treatment,
under medical supervision, including medicine for three months, varying from
doctor to doctor, based in what area he practiced, an average of $ 950 for the
first week, and $ 700 for the second week calculated, if a second week was
necessary. The first thing noticed a patient while he entered the doctor's
office, was the smell. These were not the antiseptic aroma of alcohol, which is
common in most medical facilities; There was the pungent smell of garlic. A
sign with the ufschrift "Excuse our smell. It is the DMSO at work
"hung over the application. Miss Jackson was introduced therapy in the
standard protocol for arthritis, with DMSO and diet, the initial part of their program.
^
The protocol for the DMSO arthritis therapy
The DMSO Association of Florida, Inc, recommends that every
patient who is treated with the solvent, to be trained, should be through the
comprehensive anti-arthritis program with DMSO and diet, and also under the
direct care of a physician. The program for Miss Jackson was therefore both a
learning experience, as well as a therapy. The doctor acted as teachers. A
complete work-up of food was carried out, including prescribing megadoses of
nutrients, especially pantothenic acid, niacinamide, ascorbic acid, and other
vitamins and minerals, in the form of supplements to the diet. A typical
patient with inflamed joints, as Johanna Jackson, following the specific
protocol for DMSO Arthrithis therapy.
She consulted the doctor to evaluate their existing health
problems. A medical examination was carried out, including a number of clinical
trials to determine the extent of the restriction of movement of their hands,
feet, legs, hips, her back, shoulders, her neck, and other articulations. The
grip strength was measured. At her a series of basic blood tests were carried
out, and urine analyzes were performed. Too detailed a number of laboratory
tests was not executed because of arthritis, the patient is already passed
through too many tests, probably any in this book. This over testing for
arthritis is an all to common practice, in most medical facilities. It is a
waste of money the medical consumer. Miss Jackson was an investigation of blood
deposits, a liver function test, a hair analysis, a computerized diet analysis,
and several other studies. It is important to know what the patient eats, since
earlier observations of people with arthritis showed that extensive sugar
treat, symptoms of joint pain brings. (I have something more to say on this
topic, later in this chapter.) The computerized diet analysis gave the doctor
notes, for what was the nutritional training needed. With the completion of the
preliminary tests, the patient's entire treatment program was declared. She was
handed (See Bild.7.1) to read this informative consent, and signed, in
accordance with the official position of the Medical Association of Florida, as
described in chapter 2. For Miss Jackson began the first day of treatment, with
the intravenous injection DMSO half a dose (0.5g / kg body weight). The
infusion procedure took three to four hours to complete, depending on the speed
at which the solution flowed into the vein. The next day, and the treatments
that were administered later, the full dose (1.0g / kg, mixed with 1000 cc
liquid) was added. In a week there were five days of treatment, which took
place from Monday to Friday, and a
Series weekly injections is normally sufficient, except for
people who suffer from arthritis of the spine. It takes longer to spondylitis
patients respond so that two weeks might be necessary with infusions. Also no
health insurance compensated the patient for DMSO arthritis therapy, Miss
Jackson funded a second week of treatment even as they watched as an
improvement in their joints occurred. At the beginning of the second week care,
she felt more comfortable than at any time in the recent
Past. A tape recording of the dialogue in the treatment room
between doctor and patient was as follows:
Doctor: Tell me about your progress, Johanna.
Jackson: I think it is much improved.
Doctor: In what areas specifically?
Jackson: Well, when your sister my grip strength testing by
means of this blood pressure monitor a few minutes ago, my grip strength
improved by only 20 pounds a week ago on 60 pounds today.
Doctor: Just about tripled; It is one of the best test
results that we had this month. A good progress!
Jackson: But all my fingers want to until now not close into
a fist.
Doctor: These fingers are already deformed; they will never
close fully.
Jackson: But now include these two completely (forefinger
and third finger on his right hand), although they did not before.
Doctor: Are there any other to report progress?
Jackson: Yes, my feet are better.
Doctor: How can you say that?
Jackson: Because I can walk without crutches again. I can
lift my feet up, and turn my knees without pain. And my ankles do not hurt
anymore. I think it's less arthritis in my leg joints, what do you think?
Doctor: Yes, if you can lift your feet well off the ground,
I would say that less inflammation exists. And you have definitely noticed a
difference when walking?
Jackson: I have for sure! I can do deep squats, which I was
not able to since my ninth Lenensjahr.
Doctor: Wrap plastic binding on the joints under your hips,
having had this brushed with the solution, and enter a gauze bandage, or
another envelope on the plastic. Leave these covers off overnight. Sleep with
it. The skin there is quite resistant to skin reactions by the DMSO. But do not
use Saran or other plastic envelopes above the waist because there is prone to
blistering, by DMSO administration under the plastic skin.
Jackson: I pocketed my knees with DMSO, and covered with
Saran Wrap. You think I should do the same with my ankles? Even with my hands?
Doctor: Are they there at the ankles, but not in his hands.
You may not enter into the air above the DMSO, at any joint above the waist
because it will cause blistering. Scientists do not know why the skin above the
waist is more sensitive than the lower. Brush your finger joints with the solution-all
you want, just do it. I will provide a complete description of these
impermeable plastic Einhülltechnik in the next section, but let's keep going by
following Johanna Jackson through their first week of treatment.
Figure 7.1 Informative consent
Consent form for the arthritis treatment
I, _______________ was the DMSO form of arthritis treatment
explains the intravenous and topical DMSO (administered on the skin), large
doses of vitamin C, enzymes such as bromelain from pineapple, and contains a
strict dietary regimen. I am aware that various side effects such as nausea,
depression, or skin rash may occur. I am aware about the other modes of
treatment, and I was instructed by Dr .________________ to at least obtain the
assistance of an opinion of a doctor who specializes in the traditional
arthritis treatment. I also understand that DMSO has not been approved by the
American FDA for the treatment of arthritis. Finally, in most cases,
intravenous DMSO therapy is not covered by Medicare, or another form of insurance.
witnesses:
_____________________ ______________________
(Signature) (Signature)
_____________________ ______________________
(Date) (Date)
She was taught on the first day, as the topical DMSO is to
be administered, and has also given her the arthritis diet, with the initial
supply by additional elements. On the second day Miss Jackson received a
further explanation of the diet. Gentle passive exercises were administered to
her, and more active were shown her, for their own training at home. The third
day of treatment included a demonstration on how to create the waterproof
dressing. The nurses also gave teachings on the significance of hair and diet
analysis. Reports of analyzes of hair and diet were given the patients within
10 days after the tests. The whole time was Miss Jackson evaluated by the
doctor during their physical examinations. The fourth day of treatment
consisted of more intravenous DMSO, and the formal instruction of the doctor
about the diet. Family and friends were invited to listen to the instruction,
so that the patient would get support at home, when they tried to change their
habits. Miss Jackson were prescribed daily doses of cod liver oil, because of
its vitamin Shares A, D, and E. They administered it topically, and also took
it orally. At home, the patient was instructed to a teaspoon of cod liver oil
with lemon juice twice to swallow a day to get their blood levels upright. Cod
liver oil supports the effect of DMSO. Just more passive exercises to Miss
Jackson were passed at this visit. In her last visit, she went through in turn
the entire diagnostic testing to compare their results with the baseline that
was recorded when she arrived for the first time. Although Miss Jackson would
not have decided to stay another week, she had, as usual, receive a three month
supply of DMSO, consisting of four bottles for oral, and two bottles for
topical application, with an explanation of when and how they should apply
these. As it was, at the end of the second week, she brought a 6 month supply
home.
Each Intravenous treatment procedure was the same. The
patient was instructed to take a good breakfast every morning before
intravenous circuit to be out in the mornings, where blood was drawn for
testing. The circuit took place between 8:00 AM and 8:30 AM, not later. They
brought a snack to eat during the hours of treatment. There was no
Restriktierung the bathroom privileges, everyone could go to the bathroom, and
take them with the dropper bottle that was still connected to the vein. One had
only uphold the dropper bottle, with the other hand, when in the sitting the
needle. The hand holding the needle had held down, and Vedas protected against
shocks. In the bathroom there was a catch near the dresser, where the patient
was able to hang the bottle.
^
The impermeable covering technique
The impermeable covering technique
The punch card operator Irene A. Brooks, from Bradeton,
Florida, had horror moderate pain in the left knee by osteoarthritis. Your
improvement came only from the topical application of DMSO, under an
impermeable cover, a type of plastic film, which is normally used in the
kitchen, for example, Saran Wrap, Glad Wrap or Handi Wrap. Over three months
followed Mrs. Brooks of Einhüllprozedur, administered it every time on her
knees, in the burning pain.
Then she felt a relief, at least temporarily. The
impermeable covering technique consists of the initial application of topical
DMSO, as a liquid, gel, Cerme, or ointment, to cover the area of discomfort.
Do not rub on the medication, but wear it lightly, using a cotton swab, a
wooden cotton swab, a soft and narrow paint brush or just your fingers. Wrap a
thin layer of a gauze bandage on and around the affected area. Next, cover the
entire federation, and the solvent layer from with plastic wrap. Take the tight
packaging from the first time by two hours. If no skin irritation occurred, the
next period for which they can start the cover, your total sleep period. Or you
can start even during the day. Do not wash the treated area with harsh soaps,
other solvents, or household chemicals, which could support the skin
irritation. The DMSO alone could bring a rash or irritation with it -in this
case, you stop this form of administration. The plastic covering technique
should be used in parts of the body below the waist, such as the hips, knees,
ankles, feet, or in their areas. Apply this procedure not on-- for the upper
body to the arms, hands, trunk, neck, face, shoulders or back. Plastic seems to
be too strong to cover the areas above the waist, and keeps the air from,
DMSO-treated skin.
^
The DMSO anti arthritis diet and dietary supplements
For every person with arthritis daily diet is extremely
important. The end products of red meat, such as beef, pork, veal and lamb are
especially antagonistic to inflamed joints. Kosequenter example should be
removed in the arthritic diet of red meat, at the beginning of treatment, and
during the acute flare-up of symptoms. Metabolic Research Foundation Clinica
Manner (Manner Clinic), P.O. Box 434290, San Ysrido, CA 92143-4290, (0800)
4334962 or (0800) 248-8431, the Manner recommends metabolic therapy A, for use
with DMSO. Performed by the late Harold W. Manner, Ph.D., former professor of
biology and chairman of the biology department of Loyola University of Chicago,
is the metabolic therapy A from an anti-arthritis diet and various supplements.
To get an overview of the general diet, see the table at 7.1, which shows the
foods that are allowed, and which should be during the following DMSO protocol
avoided. In addition to the recommendation that various foods should be
avoided, the Foundation also recommends that pesticides, food additives
(especially sodium glutamate, or MSG, and other additives that end with tat),
and artificial colors, flavors, and preservatives should be avoided , In
addition, sugar should be avoided, for themselves, and processed into food. The
prolonged intake of refined sugar (and other refined products), is a factor
that will contribute most to arthritis. Refined sugar reduces vitamin C stock.
Table 7.1 The Manner Clinic Anti-Arthritis Diet
Food Category Food allowed foods that should be avoided
Drink herbal teas (chamomile,
Peppermint, papaya; no
Caffeine), fresh fruit juices,
fresh vegetable juices,
purified water
Dairy products Raw milk, yogurt, butter,
Buttermilk in limited
Quantities, lean cottage cheese,
white (Farmer) cheese
Poached eggs, or cooked (a
per day)
Liquor, cola, caffeinated and
decaffeinated coffee,
carbonated beverages,
conserved and pasteurized
Juices, artificial fruit drinks
Any processed and
imitation butter, ice cream,
any unpasteurized cheese
Fried or scrambled
Food Category Food allowed foods that should be avoided
Fish fresh, white meat, grilled or baked
All fruits dried
(Ungeschwefelt) boiled
fresh, frozen, (unsweetened)
Cereals Whole grains, muffins,
made from rye, oats,
Wheat, bran, buckwheat,
Millet, and other whole
grains; Cream of wheat,
brown rice, whole
Sesame seeds, pumpkin,
Sunflower, linseed
Meat poultry but niemels fried
or breaded
No white meat fried,
or breaded
Canned, sweetened
White flour products,
sealless cereals and
seeds
like pasta, crackers,
Macaroni Snacks, white
Rice, cooked or cold
Früstücksflocken,
boiled seeds.
All red meat products, so
such as beef, pork, lamb,
calf
Nuts Any fresh, raw nuts roasted and / or salted,
especially peanuts
Oils cold produced as
safflower oil
Seasonings Herbs, garlic, onion,
Chives, parsley,
marjoram
Soups ragtag all, so
such as vegetables, chicken, barley,
Millet, brown rice
All seedlings, especially wheat, peas,
Lentils, alfalfa, and
mung beans
Sweets Rohhonig, unsulphured
Molasses, carob, not
flavored gelatin, pure
Maple syrup (in limited
Quantities)
Vegetables All raw and not
over cooked, steamed, fresh
or frozen potatoes
baked or grilled
Shortening, refined fats, and
Oils (unsaturated and
saturated), hydrogenated margarine,
or hydrogenated nut butters
Pepper, salt, hot spices
Preserved and creamy
(Thickened), generally
Millet, Bullion, fat soups
No
Refined sugar (white,
brown), chocolate,
Candies, syrups
Any canned vegetables,
frozen potatoes in each
Form, corn chips
The highest concentration of vitamin C in the body in the
adrenal glands, and chronic vitamin C deficiency. (Hypoascorbemie) leads to the
exhaustion of the adrenal glands. In a prolonged lack of adrenal glands, a
deficiency of endogenous (produced by the body) enters cortisone. Rheumatoid
arthritis is the end result of this persistent attack of the sugar on the
adrenal glands. The "demonic sugar" is thus one of the biggest
factors that support osteoarthritis, which is also known as degenerative arthritis.
Sugar suppresses the blood phosphorus. The calcium and phosphorus in the blood
are maintained by the body in a precise balance, as long as you're healthy.
Each stress relative to the body, and disease, or the intake of refined sugar
will bring the delicate and extremely important calcium / phosphorus ratio
confusion. The reduction in blood phosphorus by refined sugar causes a relative
increase in blood calcium. The parathyroid, confused "low" by the
phosphorus level, believes that the blood needs more calcium, and responds by
releasing of thyroid hormones, which pulls the calcium out of the bones. So is
now even more calcium in the blood. However, the body knows that too much
calcium in the blood cause sudden death
can, therefore, operates the body to protect itself from
hypercalcemia and death, in two ways to eliminate this excess calcium. He
separates the calcium in the urine, and also, more properly to our discussion,
it stores this in soft tissues from, as in the arteries, and in the joints. The
prolonged consumption of refined sugar leads to a veritable army of aggressors,
lashed at your body, resultiernd in arthritis, atherosclerosis, diabetes,
chronic infections, and osteoporosis. It is popular to believe that "You
are what you eat", but that is not entirely correct. The food has to be
digested and absorbed into the bloodstream before the nutrients can do the body
any good. Arthritis is a degenerative diseases, which shows that the digestion
of the ingested materials is incomplete. The food is not absorbed, so that the
body joints are nourished insufficient. To overcome this weak absorption, and
reduce the stress that is on the gastric glands and the pancreas, a tablet
hydrochlorische acid, pepsin, and enteric coated pancreatic enzymes should
contain, be taken with each meal. The Manner Clinic has made such a dietary
supplement to a part of their anti-arthritis system, and I also believe it. It
ensures the proper digestion of food. Note: For some people, supplementation of
gastric juice could cause excessive flatulence, which means that they already
have enough hydrochlorische acid. In this case, just take tablets that also
include salivary gland enzymes.
The Manner Metabolic Therapy A in arthritis includes the
following dietary supplements:
2000mg vitamin C at every meal
400 IU vitamin E, at every meal
1000mg pantothenic acid, at every meal
2 multivitamin capsules after every meal
25000 IU vitamin A (or 2 teaspoons cod liver oil) two
times a day
2500 IU vitamin D, three times a day, (including bed time)
The amount of the above-mentioned food supplement can be
halved after a symptomatic improvement is noticed. Vitamin A should be taken in
emulsified form in order to avoid liver problems. Up to € 500 000 IU
(international units) of vitamin A solution side effects was not administered
by physicians who practice the metabolic therapy, in such places as the health
and wellness center of Mineapolis, or the medical center for degenerative
diseases of Las Vegas , If elmulgiertes vitamin A is not available, I recommend
instead to use a few days 50000-100000 IU of regular vitamin A,. Note: Observe
your skin. When dehydration or scaling occurs, stop the vitamin A for a week.
If other signs of vitamin A toxicity occur, such as headaches, hair changes, or
dryness of the mouth, put vitamin A for a week from, and and take the
administration the following week at a reduced dose again. Take one half daily
dose for two weeks continued to again suspend one week. Symptoms of vitamin A
toxicity disappear, as you reduce the daily dose. Vitamin C is very important
for patients suffering from arthritis people, and megadoses, up to 15g should
be taken daily, according Manner Clinic. I would suggest a slightly smaller
size, at least initially. Make sure that the vitamin C is in the form of
ascorbates, which have a neutral pH value, and therefore problems with the
acidity be prevented. Also include Ascorbate bioflavonoids, which are important
for the proper metabolism of this vitamin. Note: megadoses of ascorbic acid can
cause gastric disorders such as Diarrhea. Acute diarrhea is show the tolerance
level of the body, and you should reduce your dose until the diarrhea stops.
A therapeutic vitamin and mineral food supplements should be
taken every morning and evening. The tablets or capsules can be swallowed with
a protein milkshake, which the Foundation also recommends (see below). In
addition to the dietary supplements that have been mentioned so far, is also
recommended on a daily basis, 3g calcium, a quarter pound of fresh liver, or 15
liver tablets, fresh wheat germ, and 6 tablespoons of bran (the breakfast
cereal) to eat. The dietary supplement superoxide dismutase (SOD) is also
supportive. Recent laboratory studies have shown that people who suffer from
arthritis or rheumatic diseases, have a reduced level of SOD in their
circulating blood. SOD is Metalloprotein, a natural enzyme. To overcome a lack
SOD, should one or two tablets, which contain the enzyme may be taken with
every meal. As a dietary supplement has an anti-arthritic effect. The
anti-arthritis diet, and the dietary supplement system should be started with a
two day juice fasting, which is also recommended by the Manner Clinic.
^
Protein milk Protein milkshake
2 eggs
¼ cup yogurt
4 teaspoons calcium gluconate
1 tablespoon lecithin
1 tablespoon safflower oil
1 teaspoon granular Kelp
½ teaspoon of magnesium oxide
4 cups skim milk
½ cup powdered non-dairy Instant
¼ cup yeast, enriched with calcium
¼ cup soy flour or powder
¼ cup wheat germ
1 teaspoon vanilla (not vanillin)
Mix thoroughly in the eggs, the yogurt, the calcium
gluconate, the lecithin Distellöl, the kelp, and the magnesium oxide by
Blender. Enter two cups skim milk added, the milk powder, yeast, wheat
seedlings, and vanilla, and mix it again. Now enter the remaining two cups of
skim milk added, and fruit or fruit juice, locust tree bread, honey, extra
vanilla or other flavorings, according to taste. Drink it two-thirds of the
cup, six times a day, at every meal, morning, afternoon, and before
going to bed.
To get used to the juice, a mixture of 50 percent apple, and
50 percent carrot juice should be taken first. As soon as possible the juice
should be omitted, and other vegetable juices are added to the carrot juice.
This is one way to facilitate drinking celery, beet, potato, or other vegetable
juices. Drink definitely not conserved juices, as the heat of the preservative
destroyed the vegetable enzymes. Prepare and drink the juice every day, to
avoid oxidation of the solutions, and eat two days
long nothing solid. Follow the anti-arthritis diet, and take
a dietary supplement while you are in treatment with DMSO. Join this diet later
on, as a part of your life stem. And avoid absolutely refined sugar in any
form.
^
detoxification
A process of detoxification takes place during the anti
arthritis diet and dietary supplement program. Every day, a coffee enema can be
administered. (This is the only useful application for coffee). Cool a cup of
brewed (not instant) coffee down to body temperature, and bring them this in
the rectum, using a rectal syringe. Keep the coffee 15-30 minutes there. The
stimulated by caffeine secretion of bile is an important part of the
detoxification plan, as it helps the alkaline condition of the small intestine
to restore. Continue with the colonics by coffee enemas until bowel movement is
normal, two times a day, if possible. Part of arthritic problems is that he or
she can not clean up of toxic products, which were catalyzed by the body. The
bowel habits are irregular. Drinking 4-8 glasses freshly prepared vegetable
juices also helps the bowel movement to bring back to normal.
^
The Manner cocktail for arthritis
The Manner Clinic uses the Manner Coctail for permanent
relief from various forms of arthritis, including tendonitis, gouty arthritis,
bursitis, rheumatoid arthritis, and osteoarthritis; chronic back pain, and
acute sprains, and bruises. The cocktail consists of a combination of vitamin
C, amygdalin, and DMSO. It was developed by Dr. Manner, around the year
1987herum, as chelating agent metal ion is likely to in the body, and improves
the electron density on the oxygen atom and the steric availability of oxygen,
giving the compound of oxygen atoms improved so that more oxygen is available
is to nourish the cells. Since it is in its approach both an anti-inflammatory,
and analgesic (causing the reduction of pain), this is DMSO infusion extremely
useful for the correction of arthritis, and their many complications. To learn
more about the administration of DMSO in the form of men cocktails out, please
contact the Manner Clinic.
^
Reported Arthritis DMSO research
In 1969, five Italian doctors explored the complications and
symptoms of rheumatoid arthritis, and tested the efficiency of dimethyl
sulfoxide in the total complaints. The journal Minerva Medica, the doctors
wrote their results down: "In this study we investigated the role of oral
dimethyl sulfoxide (DMSO) therapy in 2 patients with primary amyloidosis (AL),
a form of rheumatoid arthritis, with secondary amyloidosis (AA) which has long
had rheumatoid arthritis. The DMSO treatment produced no profitable effects, in
patients with idiopathic (cause unknown) Amyolidose. Instead learned that
patients with secondary Amyolidose a subjective improvement, a decrease in the
inflammatory activity of rheumatoid arthritis, and an unequivocal improvement
in renal function, which was followed by three to six months on the DMSO
therapy. Proposal has no serious side effects of DMSO were observed, except for
the unpleasant breath odor. We conclude that treatment with oral DMSO could
prolong the lives of patients with secondary Amyolidose. "In a study of
gouty arthritis, which was carried out in 1981 in Russia, DMSO was administered
to these complaints, and compared with indomethacin, a drug therapy. The DMSO
treatment was more effective in gout. Fabulous results have been reported in
young people with rheumatoid arthritis, in one case, in 1984, when DMSO was
administered to a girl with secondary amyloidosis, a tangle of their arthritis.
The dimethyl sulfoxide was administered by topical application to their skin.
The gastrointestinal symptoms of the young girl, and the massive Proteinurea
(protein in the urine), improved. Your posthumous left ventricular function of
the heart, and the creatinine clearance renal also improved remarkably. The ten
Japanese doctors who worked on this case, came to the following conclusion:
"The positive effect of dimethyl sulfoxide, in this individual patient
deserves further investigation by controlled trials." Two Russian
orthopedist used DMSO to rheumatoid arthritis to treat without complications,
which they report in 1981 reported in their case. Another group of Russian
doctors researched DMSO in the treatment of rheumatoid arthritis, and compared
its effectiveness with colchicine. DMSO was advantageous, and produced no
kidney complications.
Usually the disease is a chronic Still's Arhritis that
occurs in children before the age of sixteen. There are several different forms
of arthritis that affects children, and some governments limit the diagnosis of
disease Still`s as follows; A disease of childhood, characterized by arthritis
(often several joints affected), with reciprocating fever, and transient red
rash. It is often a serious disease that affects the entire body, and the state
could be complicated by an enlargement of the spleen, and lymph nodes, and
inflammation of the pericardium (heart muscle), and the iris of the eye. It
reported seven Japanese Clinic researchers over the DMSO application in a case
of Still's disease, to a 37 year-old man, with the adult onset variety. He
suffered from severe diarrhea. The Japanese doctors examined the upper and
lower digestive tract, by endoscopy, and found a swollen mucosa, with white
spots, erosion, bleeding, and Amyolid deposits. As previously explained,
amyloid is a glycoprotein, similar to starch, which is deposited in the
internal organs, in the presence of pathogenic conditions of Amyolidose.
Amyolidose is an infiltration of the liver, kidneys, spleen, and other tissues
with amyloid. The clinic staff withdrawals biopsy samples from the intestine of
man. After they administered a three-month long therapy with DMSO and
prednisolone, an improvement was observed in the endoscopic appearance of the gastrointestinal
tract of the patient. The Amyolidablagerungen in the biopsy samples have
reduced in the stomach, and appeared totally negative in the colon. Your
patient was successfully cured by the application of DMSO.
The author of Malpractice and Confessions of Medical
Heretic, Robert S. Mendelsohn, MD, of Chicago, who, before he died, associating
professor of establishment of preventive medicine and health, was in medical
school at the University of Illinois, said in an interview "Since my experience
with DMSO 17 years ago, I think it should be like any other medicine-with
tackled extreme caution. Should it be used for arthritis? I would look at it
like any other drug-use it, whom all else fails. My opinion is that a person
should begin to live properly first, under the conditions of good nutrients,
suffizientem training, and healthy living stem, then his arthritis is
completely improve by itself. One must not DMSO as a way to use just because
you then Indocin, codeine, Motrin, Butazolidin, Gold injections, and other
anti-inflammatory agents is not required.
"This, despite our observation of very few reports of
side effects DMSO -as well no deaths. If I had to einordenen therapies, I would
place the DMSO way ahead, in front of the conventional anti-arthritis drugs. It
is preferable to any of these. But I would classify the DMSO use behind a
regular diet and good nutrients ..... I suggest water exercises for people with
crippling arthritis. What happens if they can not make these water exercises?
Well, if not, then go directly to the DMSO.
"My argument is, if the government proceeds, to protect
you from the application of DMSO, this should absolutely keep away from the use
of all the other conventional arthritis drugs, which as we know, hold many
dangers. We do not know of any threats relating to the DMSO. Of course,
"added Dr. Mendelsohn," this type of argument would throw the
rheumatologist out of business. "What did I do with all the people who
came to me to relieve her arthritis? I have discontinued their medicines that
they have taken; I improved her diet, I joined them with water exercises; it
bothered me that I was not prescribed DMSO; I wonder why is that?
"It is a question that will face many doctors
themselves, in the coming weeks. Thousands of people, who are suffering from
arthritis, ask yourself the same question. When will we be able to obtain DMSO
per prescription, or over the counter, as we received other anti-inflammatory
drugs? "
^
Chapter 8
The adaptation of DMSO to foot and leg problemsshake
The adaptation of DMSO to foot and leg problems
In the spring of 1963, to DMSO was still in the laboratory
research, and was not yet adapted to human administration. It was the time when
Sam Bell of Bloomington, Indiana, now the track coach at the University of
Indiana, but at that time the manager of the State University of Oregon in
Corvallis, Oregon, came into contact with the solvent, for the potential
treatment of leg and foot problems. "At that time I had two athletes who
had leg problems," said Mr Bell said Senator Edward M.Kennedy with, the
chairman of a hearing, which was conducted July 31, 1980 by the Subkommittee
the Senate for health and scientific research, the Committee for labor and
human resources. The hearing was a deep insight for the Senators Howard M.
Metzenbaum (DOhio), Richard S. Schweiker (R-Penn), and Orrin G. Hatch (R-Utah)
that Senator Kennedy joined in the "investigation of Tests of DMSO, and
the role of the FDA in the process. "the two athletes who described Sam
Bell, were Morgan Growth, and Norman Hoffman, both world class 800 meter
runner, and were both potential champions in the National Collegiate Athletic
Association (NCAA) .But Growth had an inflammation of the achilles tendon, and
Hoffman was suffering from a pulled muscle hamstring. "We had with each of
them is a chronic problem," said Sam Bell continued, "and what we
workout as made with them, had no effect on them. I had read in the newspaper
about some of the things that Dr. Jacob discovered with DMSO, and I called him
at the medical center of the university-Oregon, and asked him if I could bring
these two athletes to him so that he is this look. We visited him, and he
examined it, and gave us some DMSO, and told us how it was used. We applied it
topically; which means that we have given it to the skin. "
The recovery of the leg tendon of Growth was nothing less
than remarkable. The Achilles tendon injury, according to Coach Bell is a
chronic injury that heals poorly, but even by itself when one has really hit
them. But this spring, was Growth NCAA champion in the mile run at the
University of New Mexico. And the hamstring problem by Norm Hoffman, which
prevented him from training was completely dissolved. Hoffman landed the
champion title of the 1963 NCAA in 880 meters running. Coach Bell had some of
the DMSO over, and when he did some gardening, he sprained his ankle when he
dug up a tree stump. It was the return of a previous injury from his football
days at the college. "I made the decision that I would perform an
experiment with the DMSO by myself," said Bell, "and I administered
myself six treatments over a period three days. My ankle swelled as it was an
old injury, always very viciously when I sprained it back to me. Within three
days, I had no swelling, no soreness, and no discoloration; I could do anything
I have done before. His next experience with the agent, brought a case from
1964 with it. At this time led Bell by a two-day Olympic test, in track and
field, at the State University of Oregon. One of its participants was a young
man, Daryll Horn, expected by the Bell, that he would win a place in the
Olympic team of the United States. Horn was the number two rank long jumper,
and the number two in the ranking triple jump in the country. Triple jumping
involves jumping, step and a jump in a three-step jump, which is very difficult
for the feet, and extremely strong legs requires. Darryl Horn had graduliert at
the State University of Oregon, in the middle of 1963, and went to the Air
Force. It was then allowed him and he was released to go to the Olympic trials.
Previously, he was trained at Stanford University in California, where the
Olympic trials were held. Bell flew to Southern California to oversee the
Olympic trials, but he could horn in the training Kamp there find not. He asked
Peyton Jordan, the coach at Stanford University, which he believed, where the
young athlete unless. Jordan said: "I do not say it will be happy, but he
had a massive pulled hamstring on Monday, and he is to get in Palo Alto a
treatment as long as possible before her coming back here. . But there is no
way that he can compete "Immediately cried Bell Daryll Horn in Palo Alto,
California, and heard how the athlete said," Coach, I'm black and blue on
the gluteus (the large muscle on the backside) down to my knees. I can not walk
without a limp. "The coach called Horn on," an aircraft to take, and
come here as quickly as possible. "Then he called Dr. Jacob in Portland,
Oregon, and asked him if he something DMSO could get to treat the young man.
"If you have someone who takes it meet, I will deliver the DMSO,"
replied Dr.Jacob.
Bell asked a friend to go to Dr. Jacobs practice, and to
transport the agent to the airport of Portland, where he found a stewardess who
took it to the airport of Los Angeles. The coach was waiting for this aircraft,
and got the DMSO. Daryll Horn came to treat with the next flight from Palo Alto
on Thursday, the Olympic trials were scheduled for Saturday afternoon. Bell
doused the violation of the athlete with DMSO. The smell led Horn's roommates
to move the sleeping accommodation. Skin irritation occurred Horn's on leg,
which they ignored. The immense discoloration of leg injury immediately began
to fade, and the pain went with her. "To make the long story short,"
said Bell, "we bathed Daryll almost two days in the stuff, and on Saturday
afternoon, he missed the Olympic team by a quarter inch. On Sunday we returned,
and he took up again, we have it all Saturday night, and treated on Sunday
morning, so he came back, and went again, and missed the Olympic team in the
triple jump to one-half inch. He came clearly not to go to where he was, but
the fact that he was ever able to compete is, so I think a little miracle. He
went on with no discoloration of the foot; it was totally gone within 2 days,
and the soreness was gone. I think the strength was obviously not completely
back, but the fact that he was able to act at all, is an amazing thing. "
^
Placing the DMSO in the Foot Care Medicine
At about the same time as Sam Bell, Darryl Horn proposed as
a member of the Olympic team of the United States, the DMSO intrigued
scientists around the globe. Pharmaceutical companies began to allocate amounts
of the agent for research. They requested the participation of selected and
respected medical researchers who were willing, in clinical trials with enter,
in its various specializations. They began, DMSO for burns, arthritis, skin
problems, musculoskeletal pain
apply all kinds, and many other problems. "Soon there
were hundreds of publications that reported by` Wunderkuren` with the agent for
all ailments ranging from ingrown toenails, to vascularen
Headache. "Said Dr. Jack C. De la Torre, associating
Professor of Neurosurgery and Psychiatry, Medical School, the University of
Miami. The Merck, one of several pharmaceutical companies DMSO moved as a
commercial product in the light, and said medical organizations important to
seek out outstanding members as researchers. The American Association of
Podriaten (APA), was asked early in 1965 to choose the doctors Podriatischen
medicine that would participate. I, Morton Walker, D.P.M. had, just won 1964
the silver anniversary of the APA, the Gold Medal for scientific researches and
writings, the highest award ever given by the Federation of American
podiatrists. Therefore, executives from Merck have written to me to win me as a
candidate for her research project DMSO. The FDA had already approved elsewhere
clinical research which previously brought me nine additional awards for
research, writings, and scientific exhibits. I got about 22 such awards. The
company Merk offered me any costs for the study and the records, which
concerned the DMSO treatment in foot and leg problems, to take over. During
this period, 1964-1965, the pharmaceutical company Merck, Syntex, Squibb,
Geigy, Schering and American Home Products gave composed of $ 20 million to
fund the clinical trials. It 1500 clinical researchers were involved, and most
of them were doctors. In spring 1965, when the pharmaceutical company Merck
presented me their offer to encourage me, it was podiatrists from Connecticut
not allowed by law to administer an internal medicine, so the agent was applied
only to the skin, in foot and leg problems.
In front of this new clinical tests by the company Merk, I
had completed a study of the company Armor Pharmaceutical, over the
chymotrypsin (a pancreatic enzyme) Chymar (whose name has now been changed in
Biozyme). In these researches I administered the Chymar ointment under a dense
Umantelung. It was the first time that plastic covers are used in podiatry to
bring a medicine in locally affected inflamed tissue at the base, for example,
corns or calluses. I adapted this technique for clinical trials with DMSO, and
they worked very well. I also introduced a technology in order to bring in the
DMSO, especially in deep-seated injuries, such as painful heel spur, by I used
ultrasound. Instead of the normal ultrasonic gel or mineral oil, DMSO, as the
connecting means between the quartz of the ultrasound device, and the skin.
This worked well. I had to eliminate many of the heel spur inflammation of my
patients are able. This foot and leg studies were conducted, various over a
period of four months, beginning in 1965. precautions were taken before the
start of the studies. It was read a lot about the subject. For two months a few
podriatische patients received the DMSO treatment. A long memorandum the
pharmaceutical company came on 8 September 1965, as acting with detailed
information about the benefits of the product, as the doctor has to apply it,
for what it is, and as DMSO in the body. This memorandum was handed over to
each medical researchers in the country, which had been certified by the FDA,
the DMSO applied on an experimental basis. An employee of the company Merk
visited me with another DMSO delivery, and reporting forms to the reactions of
the patient record in a clinical trial with comprehensive scope. An unknown to
me wife died on September 9, 1965 in Ireland by the administration of DMSO.
This report has not been documented, and possibly they died of some other cause,
just as they used the DMSO. But this death produced panic among the officials
of the FDA, and had great political impact on Dr.Stanely Jacob, and his
colleagues at the University of Oregon. No release of the pharmaceutical
company or the FDA regarding that incident came in, however, the clinical
research on DMDO with foot and leg problems continued. I led to less serious
problems of 124 patients in clinical trials. Excellent results emerged from the
various applications of DMSO. Recordings were made; objective and subjective
observations were reported in the form provided; more DMSO deliveries were
requested. In this study, there was podriatischen on 10 November 1965 an abrupt
stop, because a doctor's letter came in, which prompted us to cease all research
in this project. The FDA requested that all used and unused supplies of DMSO,
and all records of patients for whom it was administered, must be returned
immediately to the sponsoring pharmaceutical company. I did not have these
things to return because I promptly visited a company employee, and all
took-all patient reports that stocks of DMSO, and even the duplicates of
reports. We were instructed to report any adverse health effects from the use
of the product, but there was none. No such report was published in the medical
literature ever, during this four-month podriatischen study on the adaptation
of DMSO to a variety of foot problems. All the records of clinical trials were
confiscated, and what followed was strictly speaking the impressions from this
research, 27 years later. They were based on the personal history of personal
foot health history of patients in relation to their individual Toe, foot,
Fußgelenk-, or leg problems.
^
Bunions the big toe
Bunions
der großen Zehe
Bunions entstehen
durch die Abweichung zweier angrenzender Knochen, normalerweise am Gelenk des
großen Zehs, und des ersten Mittelfußknochens. Es gibt zwei Formen Bunions. Der
akute Typ, oder die Bursitis, ist aprupt und schmerzvoll. Wenn ihr nicht
ordentliche Aufmerksamkeit gewidmet wird, wird das akute Bunion größtenteils in
den Typ 2 übergehen—dem chronischen Bunion, oder hallux valus,
welches sich oft in der
schmerzhaften Deformation des
großen Zehs äußert. Manchmal, wie auch immer schmerzt es
stark.
Die Bursitis Bunion
ist die Entzündung des Schleimbeutels, eines Sackes der eine Flüssigkeit von der
Konsistenz von Eiweiß beinhaltet. Dieser Schleimbeutel agiert als Schmiermittel
zwischen der Haut und den Knochen. Kontinuierliche Irritation
durch extremen Druck, so wie
bei schlecht sitzenden Schuhen,
verursacht, dass der Sack sich entzündet, und der Zustand akut und schmerzhaft wird—eine
Bursitis.
Hallux Valgus ist ein
allgemeines Leiden, dass den Fuß belastet, und ein abnormales Vorragen des Gelenkes
der großen Zehe verursacht. Es verdickt den Fuß, und bringt einen Verlust an
Balance mit sich. Stehen und gehen wird schwierig. Arthritis im Fuß Kann früh
im Leben auftreten, durch diese Beschwerde.
Osteoarthritis ist
die regelmäßige Konsequenz des Ignorierens des Bunions an der großen Zehe. Verkalkung
an den Punkten, an denen der Stress auftritt; Gelenkserweiterung kommt dazu; der Deformierung kann
nur durch größere
Schuhe entgegengetreten werden.
Durch die DMSO Verabreichung verbesserte sich das akute
Stadium des Bunions, primär die Bursitis bemerkenswert. Hallux Valgus
machte dies nicht.
Das luftdichte Abschließen,
sowie die Ultraschall
Methode funktionierten sehr gut, mit dem DMSO, das auf die entzündeten
Bereich gestrichen wurde. Bei der
Prozedur wurde DMSO
und Ultraschall als Praxisbehandlung
angewendet, und anschließend die Patienten
nach Hause geschickt mit DMSO unter einer Plastikabdeckung, die drei Tage
angelassen wurde, mit einer schützenden Filzpolsterung, und einem
unterstützenden Binde. Zur Zeit dieser Studie wurde kein DMSO verwendet, für
die Anwendung durch den Patienten zu Hause, da nicht sicher war, welche
Nebenwirkungen auftreten würden. Es wurde strikt unter meiner Kontrolle
gehalten, und ich verabreichte es in der podriatischen Praxis. Unweigerlich
verschwand der Schmerz des Bunions, bis
der Patient zurückkehrte. Keine weitere Behandlung war
notwendig, bis bei
dem Patienten das Bunion
wieder aufflammte, durch das Tragen von modischem, aber
schädlichem Schuhwerk.
^
Hammerzehen
Die Hammerzehe, eine der
schmerzhaftesten Fuß Alimentationen,
ist gekennzeichnet durch die Kontraktur der
Sehnen am Vorderfuß. Zugehörig
zu diesem Phänomen ist
eine Laxheit der Ligamente, sowie eine Winkelung der zweiten und dritten
Phalangen, der individuellen Knochen jedes Zehs.
Enge Schuhe pressen
den Fuß, und engen die Muskel ein, die
die Zehen bewegen, so dass die Muskel verkümmern. Die Bewegung der Zehen wird
kümmerlich und matt. Die Zehe sucht Platz, wo immer sie kann in dem krank
machenden Schuh. Sie kringelt und wölbt sich, bis der Zehnagel fast vertikal
ist. Der betroffene Zeh kann aufsteigen, sich zusammenziehen, und andere
Zehen überlappen. Dessen Spitze kann bei jedem Schritt auf den Boden
schlagen, und flach und kompakt werden. Ein hartes Hühnerauge kann entstehen,
und der Nagel kann sich spalten, und einwachsen.
Obwohl jeder
Zeh so betroffen
werden kann, leidet
der zweite am
ehesten daran. Er ist
normalerweise länger, als die anderen Zehen. Die experimentelle DMSO Behandlung
war die selbe, wie bei akuten Bunions—erst das Mittel mit Ultraschall
verabreicht, und dann einen Verband mit dichtem Plastik über die
Lösung gewickelt. Bei einer
Nachuntersuchung des Patienten in
drei Tagen, zeigte sich,
dass der Schmerz
vom deformierten Zeh verschwunden
war, obwohl die Deformation zurückblieb. Der Schmerz
könnte einen oder zwei Tage später zurückkehren, wenn nichts getan wird, um die
Verformung permanent zu korrigieren.
^
Arthritis
der Füße
Arthritis kann alle
Gelenke im Körper betreffen, einschließlich die der Füße. Arthritis in den
Füßen entsteht in den meisten Fällen durch mechanische Belastung, nicht aus
einer Infektion heraus. Sie wird
manchmal begleitet von angestoßenen Knien, gebogenen Beinen, flachen und schwachen Füßen. Der
Zustand unterstützt auch
solche Deformationen an den Füßen,
wie Senkfuß, hoch gewölbtem Fuß, Hammerzehen, Bunions und
Fersensporn. Obwohl Arthritis zu dieser Zeit nicht kuriert werden kann, kann
das schmerzende Elend, und die Beschwerden, welche diese Krankheit begleiten,
zum Teil gelindert werden. Die Behandlung von Arthritis in den Füßen muss auf Beides
gerichtet sein, auf
die generelle Ursache, und auf die Linderung der
lokalen Symptome. Die
generelle Behandlung des ganzen
Körpers liegt in der Verantwortung Ihres Familienarztes.
Die Behandlung kann den Aufbau Ihrer Resistenz durch Diät, Übungen, Entspannungstechniken,
Gewichtskontrolle, und anderer Dinge mit einschließen, so wie der Dinge,
die Ihren Lebensstiel
ausmachen. Die lokale
Behandlung kann Fußerholung, Hitzeanwendungen, Schienung,
Streckverband, physikalische Therapie,
und den Gebrauch von Arzneimitteln beinhalten.
Es wird auch
auf spezifische Ursachen
geachtet, wie mechanische Überbelastung, allergische
Faktoren, klimatische Bedingungen,
angeborene Defekte, Tumore, Infektionen, Verletzungen,
Vergiftungen, Kreislaufstörungen, Nährstoffmangel u.a. Wenn Sie DMSO als lokale
Behandlung anwenden, sind Sie in der Lage, sich selbst sehr zu helfen. Das
folgende Pflegeschema kann ein rotes, heißes, und geschwollenes arthritisches
Gelenk lindern, egal, ob es sich um die Ferse, das Fußgelenk, oder um die große
Zehe handelt. Arthritische Zehen reagieren recht gut auf diese Prozedur.
1. Streichen Sie das
akut entzündete Gelenk mit einer Menge
an ca. 70 prozentigem,
oder etwas höher konzentriertem DMSO
ein. Gehen Sie
nicht über 90
Prozent, da die Abdeckmethode, die folgt, schwere
Hautreaktionen durch das DMSO unter der Abdeckfolie verursachen könnte.
2. Umwickeln Sie den
gesamten, entzündeten Fuß mit mehreren Lagen einer Mullbinde.
3. Vielmehr als die
Haut direkt einzustreichen, können Sie die Mullbinde zuerst anbringen, und dann mit DMSO sättigen.
4. Bedecken Sie den
ganzen Bereich mit einem Gummituch, oder mit dünnem Schaumgummi.
5. Legen Sie
eine Schicht Lappen
oder Filz auf,
welche in heißes
Wasser getaucht und anschließend ausgewrungen wurden.
6. Platzieren Sie
Flaschen mit heißem Wasser um den entzündeten Bereich, oder bedecken Sie diesen
mit einem elektrischen Heizkissen, eingewickelt in Handtücher.
7. Halten Sie die
Wärme, indem Sie alles mit Frottiertüchern abdecken.
8. Heben Sie den Fuß,
und das Bein auf eine Ebene mit dem Herzen an.
9. Fahren Sie mit
dieser Behandlung so lange fort, wie sie Ihnen bequem ist, allerdings nicht
länger als 60 Minuten pro Einzelanwendung.
10. Wenden Sie das
DMSO, soweit nötig, alle vier oder fünf Stunden erneut an.
Nachdem Sie diese
Behandlungsmethode über 12 Stunden angewendet haben (Bei einem Maximum von drei
Mal), entfernen Sie die Pads, Flaschen, Verband, und waschen den Fuß, um alles
DMSO zu entfernen. Verabreichen Sie eine beruhigende Lotion, oder eine Salbe
aus der Korthisonfamilie, oder Aloe Vera auf den behandelten Fuß. Vorsicht:
Beachten Sie, dass Sie zwei Therapieformen in dieser Prozedur verwenden --DMSO
mit seinen entzündungshemmenden Eigenschaften, und feuchte Hitze, mit ihrem
eigenen entzündungsreduzierendem Effekt. Die Hitze scheint DMSO zu größerer Wirksamkeit
zu Katalysieren. Aber ich möchte Sie ermahnen, dass Sie eine zu große
Hautreaktion durch das DMSO hervorrufen können— und sogar eine zu große entzündungshemmende
Reaktion. Zu viel von etwas ist nie gut. Deshalb möchte ich Ihnen energisch
anraten, vorsichtig mit dieser Behandlung zu sein, zumindest bei den ersten
fünf Anwendungen. Kontrollieren Sie den Zustand Ihres arthritischen Gelenks,
und der Haut darüber. Erlauben Sie keine Hautirritation. Messen Sie Ihre
Körper-temperatur. Wenn Sie fiebrig werden,
beenden Sie die
Prozedur. Entfernen Sie
die Abdeckungen, wie
unter Punkt elf beschrieben, und beruhigen Sie den Fuß.
Dies ist ein sehr potenter Weg, um den involvierten Fuß von einer arthritischen
Entzündung zu befreien.
In der Praxis, im Jahre 1965, wurde diese Methode mit Erfolg
angewendet, allerdings wurde sie verabreicht durch einen Arzt der
podriatischen Medizin,
welcher wusste, wie er
diese Art von Reaktionen vermeiden
konnte. Die Schmerzen,
die Schwellung, sowie
andere Zeichen der Entzündung verschwanden aus dem Fuß des
Patienten in der Fußpflegepraxis, während der Patient in einem kleinen
Behandlungszimmer beschäftigt
wurde. Er oder
Sie gingen nach Hause, ohne Beschwerden,
und die Linderung blieb einige Tage.
^
Harte
und weiche Hühneraugen
Ungefähr 40 Prozent
aller Personen, die einen Podiatristen
besuchen, machen dies ursprünglich wegen Problemen mit harten oder weichen Hühneraugen, und 80
Prozent dieser Menschen sind weiblich. Harte Hühneraugen sind Gewüchse der
Hornhaut, im allgemeinen auf der
Oberseite der Zehen. Weiche Hühneraugen wachsen zwischen den Zehen. Beide Typen können leicht vom normalen Gewebe,
das sie umgibt unterschieden werden. Innerhalb eines harten oder weichen
Hühnerauges befindet sich eine zentrale Radix, oder Auge, aus harter grauer
Haut, und um das Zentrum befindet sich ein schmerzhafter entzündeter
Ring aus Haut und Fleisch. Schmerz
ist normalerweise das Hauptsymptom.
Die Hühneraugen
werden verursacht durch
Reibung und Druck durch den
darunter liegenden Knochen. Eine
scharfe Ecke der Zehenknochen reibt die Haut von Innen, und manchmal reiben schlecht sitzende Schuhe die Haut von
Außen. Die Haut stirbt eventuell ab, und baut Lage um Lage auf, um das Korn zu
kreiren. Irritation und Schmerz steigen, wenn das Korn wächst. Menschen, die an
Hühneraugen leiden, können von ihrem Problem entweder permanent,
oder
teporär befreit
werden. Niemand muss die pein eines harten Hühnerauges aushalten. Temporäre Linderung schützt nicht davor, dass das Hühnerauge an der selben Stelle wieder wächst.
Es ist palliativ.
Das Aufpinseln von
DMSO war so eine vorübergehende Maßnahme. Es wurde gemacht, nachdem das
Hühnerauge „rasiert“ wurde, um die Hornhaut,
die die Beschwerden verursacht zu entfernen. Keine Polsterung mit
Moleskin war nach der pallitativen Entfernung der Hühnerauges notwendig, wenn
das Auftragen von DMSO der Prozedur folgte; wie auch immer, das Hühnerauge kam
bald zurück, ohne das permanente Entfernen des darunter liegenden Knochens.
^
Schwielen
Schwielen sind
verdickte Massen an Haut, die sich auf den mit Gewicht belasteten Oberflächen
der Füße formen. Sie entstehen aus konstanter Reibung und Druck. Die pathogene
Schwiele, welche auf dem Fußballen entsteht,
ist nicht gesund. Diese Art einer gewachsenen Schwiele ist umringt von einem
entzündetem roten Kranz, und Flüssigkeit durchdringt das darunter liegende Gewebe.
Sie ist oft geschwollen, heiß und schmerzhaft, und erscheint regelmäßig als
eine harte, trockene, hornartige Masse, aus gelblicher oder gräulicher Haut.
Sie kann im Zentrum dick sein, und sich graduell zu den Seiten verjüngen. In
ihrem Zentrum kann sich ein tiefer, harter, grauer Mittelpunkt befinden, welcher
aussieht wie ein Kiesel, wenn man ihn entfernt. Wegen der verdickten Haut bei
Schwielen verliert diese ihre Elastizität, und die Haut streckt sich nicht mehr
in seine normale Länge um den Fußballen aus, wenn die Füße abgebogen werden.
Diese Schwielen scheinen zu „brennen.“ Manchmal wird eine korrigierende
Behandlung durchgeführt, indem Der Druck auf den Fuß, durch unterstützende
orthopädische Hilfsmittel reduziert wird, welche in den Schuhen getragen
werden. Übungen könnten verordnet
werden. Die Schuhe
könnten gewechselt werden.
Oder es wären chirurgische Korrekturen
des involvierten Mittelfußknochens nötig,
sowie die begleitende Kontraktion der Zehen. Meistens
bekommt eine Person mit Schwielen diese weggeschnitten. Wenn DMSO nach
dem Wegschneiden aufgetragen
wird, ist kein
Moleskin Pad nötig,
um den empfindlichen Bereich zu
schützen. Wie auch immer, DMSO durchdringt nicht die hornartige Haut, man muss diese zuvor entfernen.
^
Plantarwarzen
Plantarwarzen
Plantarwarzen wachsen
auf der Sohle des Fußes als erhobene Klumpen, oder
Fleisch. Sie sind gutartig, und wachsen tumorähnlich, und sind gut
versorgt mit Blutgefäßen und Nerven. Man könnte
sie mit Hühneraugen
oder Schwielen verwechseln,
da sie bedeckt
sind mit Schwielengewebe, und
weil sie schmerzen. Die Plantarwarze ist perlweiß, weich und schwammig, und hat
winzige schwarze, braune, oder rote Punkte in ihrem Zentrum. Diese Punkte sind Blutgefäße. Gehen flacht die Warze ab, so dass das Gewebe verdickt
und spröde in
seiner Struktur bleibt.
Die Größe verändert
sich von einem Stecknadelkopf bis zu einem Silber
Quarter, sie wächst entweder einzeln, oder in Trauben. Es trifft einen schwer,
wenn sie gedrückt wird.
Eine Verletzung des
Plantars des Fußes erlaubt das Eindringen eines Virus in die Haut, der das Wachsen der Plantarwarze verursacht.
Es ist Tatsache, das die Warzensaison im Sommer ist, wenn die Menschen barfuß
laufen, und die Unterseite ihrer Füße verletzen. Es existieren
verschiedene Techniken, um die
Plantawarzen zu entfernen. Das
Auftragen von DMSO ist eine von
ihnen. Alles was es macht ist den Schmerz durch die Plantawarze zu nehmen, nachdem
die darüber liegende
harte Hautschicht weggeschnitten wurde.
Danach wird eine Plastikabdeckung über dem DMSO
angebracht, daraufhin maziert die Warze, sie wird weicher, und geht vielleicht
von alleine weg.
^
Eingewachsene
Zehnägel
Bei eingewachsenen Zehnägeln
durchdringen die seitlichen
Ecken des Nagels
die Haut, und schneiden
in das Fleisch
des Zehes. Wenn
dies nicht bald
korrigiert wird, können
schwere Komplikationen resultieren. Die
Komplikationen, wie Entzündung,
Infektion, Geschwürbildung, und
Wundbrand können fortschreitend
aufeinander folgen. Jemand, der an eingewachsenen Zehnägeln leidet, ist
selten in der Lage, den
Schmerz zu ertragen,
und sucht normalerweise
Hilfe, bevor ernsthaftere Komplikationen auftreten.
Teenager scheinen besonders
anfällig zu sein,
da sie die
frühen Warnungen der Erwachsenen außer Acht lassen. Unkluges Schneiden
der Zehnägel ist die häufigste Ursache. Zuerst tritt eine Entzündung auf, dann
eine Verfärbung, eine milde Schwellung, und ein Austreten von Flüssigkeit. Eiter
und Rötung entsteht, und die Zehballen schmerzen, wenn diese vorgehenden Anzeichen ignoriert werden. Eine
blutige Masse an Material wird entstehen, welche man „Wucherung“ nennt, an den
Ecken der Nägel, zwischen der Nagelplatte und der Nagelnut. Wenn die Behandlung jetzt nicht verabreicht
wird, kann eine gefährliche Infektion auf dem gesamten Zeh entstehen, und rote
Schlieren treten eventuell am gesamten Oberfuß auf. Das muss nicht geschehen,
wenn die Behandlung schnell, schmerzlos und andauernd ist. DMSO lindert die
anfänglichen Symptome von eingewachsenen Zehnägeln, durch Auftragen eines Tropfens auf
den entzündeten Bereich.
Allerdings ist dies
nicht die beste
Vorgehensweise, da andere
fortschreitende Symptome zu einer Infektion führen.
^
Club
Nägel
Ältere Menschen
haben manchmal dicke,
häßliche, deformierte Zehnägel,
ein Zustand, der symptomatisch für eine systemische
Krankheit, oder chronische Verletzung ist, so wie Jogging in schlecht passenden
Schuhen. Durch die Verletzung sehen die Zehnägel oft verfärbt, verlängert und verdickt
aus.
Überwachsene Zehnägel
sind bekannt als
Club Nägel. Sie
können extrem hart und
kringelig werden, unten an den Zehen, vergleichbar mit der Form eines
grotesken Bockshorn. Die Reduktion dieser Nägel muß nicht schmerzhaft sein.
Tatsache ist, das es besser ist, diesen hornähnlichen Nagel so kurz
wie möglich zu
schneiden, um so
einen Nistplatz für
umliegende Pilzparasiten zu vermeiden, in welchem diese wachsen
können.
Die Nägel werden
zuerst mit Rizinus Öl, oder warmen Olivenöl, kombiniert mit 90 Prozent DMSO eingerieben.
Dies erweicht die Nägel, und reduziert deren Empfindlichkeit an deren Wurzeln.
Sie werden mit einem
kräftigem Nagelzwicker geschnitten. Die
Glättung der rauhen
Ecken ist erforderlich, so
dass die Strümpfe
nicht beschädigt werden.
Nebenher gibt das
dem darüber liegendem dicken Nagel ein besseres Aussehen. Wie auch
immer, die Hauptaufgabe bei der Reduktion überwachsener Nägel ist, den Druck
von den Nagelnuten zu nehmen, und so die Quelle der Beschwerden zu eliminieren.
Die Reduktion schafft auch mehr Platz in den Schuhen, in denen sich der Zeh
bewegen kann. Mehr Platz in den Schuhen kann auch den Druck reduzieren, und Hühneraugen
verhindern, die sich an den benachbarten Zehen bilden.
Nachdem die oben
beschriebene Prozedur abgeschlossen wurde,
können die abgeflachten Nägel wieder
mit einer Mischung
aus DMSO und Öl
eingestrichen werden. Dies
bringt einen lang anhaltenden Effekt von Komfort mit sich,
sowie bringt es auch das vormals komprimierte Gewebe darunter zurück, zu einem
normaleren Zustand. Um das Überwachsen von Nägeln, so wie bei dem Zustand der
Club Nägel, zu verhindern, beachten Sie bitte folgende einfache
Vorgehensweisen:
• Wenn Sie Ihre Zehnägel schneiden,
schneiden Sie diese kurz,
aber schneiden Sie diese quadratisch,
quer
• Benutzen Sie einen
Nagelzwicker, runden Sie
die Nägel in
keinem Fall. Nach dem Schneiden, platzieren Sie einen Tropfen DMSO in
mittlerer Stärke auf das geschnittene Ende.
Es gibt wenig in der
Humananatomie, was nicht einem spezifischen Zweck dient. Sogar das Haar auf dem
Kopf hat seine Funktion, auch
Zehnägel haben ihre-- in diesem
Fall, die Knochen und Nerven der Zehen zu schützen. Jetzt, weil
wir Schuhe tragen, können die
Zehnägel, anstatt die Zehen zu schützen, eine Quelle für Ärger
darstellen. Wie auch immer, wir können
uns vor den Problemen schützen, die sie verursachen können, indem wir sie ordentlich
pflegen.
^
Nagelpilz
Infektionen der Zehnägel
durch Pilz befinden sich unter
den meisten, regelmäßig
beobachteten Nagelproblemen. Eine aus
vier Personen, welche
einen Podiatristen konsultieren,
hat so eine Nagelkrankheit. Nagelpilz wird durch
Parasiten, wie Hefe, Schimmel, oder Pilz verursacht, alle von ihnen wachsen als Scherpilzflechte. Diese
Parasiten sind weit
verbreitet in Schuhen,
da diese das
einzige Kleidungsstück sind, welches niemals innen gründlich gereinigt
wird, und deshalb eine konstante Quelle für Infektionen und Reinfektionen
darstellt. Nagelpilz erscheint trocken, glanzlos, skaliert, und
gestreift; er ist
erhoben vom Nagelbett,
und er hat
eine
gräuliche-gelbliche-bräunliche, wurmstichige Erscheinung. Der ganze
Nagel, oder ein Teil davon kann betroffen sein, da wenn die Infektion
voranschreitet, sich diese
zurückarbeitet zu der Nagelwurzel.
Die Durchschnittsperson schenkt der verkrüppelten Erscheinung des Nagels
keine Aufmerksamkeit, da diese schmerzlos ist. Aber infizierte
Nägel sind die
Ursache für den
athletischen Fuß. Bei
der Behandlung des Nagelpilzes entfernt der Podiartrist die
verkrustete, puderartige Substanz, und formt sowie feilt den Nagel dünn. Er
kann das orale Antibiotikum Grisevolin verschreiben, den Bereich mit
Kupfersulfat ionisieren, und verschiedene Flüssigkeiten
auftragen, sowie fungizide
Salben. In vielen
Fällen werden die Nägel vollkommen entfernt, entweder
temporär, oder permanent,
abhängig von der Ernsthaftigkeit
des Problems. Wird
der Nagel temporär
entfernt, richtet der
Doktor seine Behandlung auf das
Nagelbett aus, und auf das Zentrum des Wachstums, von welchem der Nagel nicht
durch den Pilz infiziert wächst. Das ist der Ort, an dem das DMSO effektiv
funktioniert. Eine Paste wird hergestellt aus 30cc des 90 prozentigen
Lösungsmittels, mit zwei 250 mg MicroFormat Grisevulvin Tabletten. Verteilen Sie die Paste auf der Martix des Nagels, nachdem die Heilung des
Nagels stattgefunden hat.
Halten Sie die
DMSO Paste in
Position mit einem Klebestreifen, und behandeln Sie die
Zehnägel jeden Tag auf die selbe Art. Neu gewachsene, nicht infizierte Zehnägel
können unter dem Fleisch
erscheinen, in ein
paar Monaten, die
auf den chirurgische Eingriff
folgen. Lassen Sie
die Paste die
gesamte Zeit dort,
die der neue
Nagel benötigt, um über das gesamte Nagelbett zu wachsen—ungefähr sechs
Monate. Andere flüssige Fungizide
können mit dem DMSO gemischt, und
auf das geheilte
Nagelbett gestrichen werden. Formen
Sie eine Lache
unter der Fleischlasche, überwigend
an dem Wachstumszentrum des
Zehnagels. Wenn der Nagel auswächst, wird er kontiunierlich in Kontakt mit dem
penetrierenden Fungizid sein, speziell, wenn ein Stück Plastik über den Zeh
geklebt wird. DMSO ist selbst fungizid, so dass Sie das Problem mit zwei
Mitteln auf einmal behandeln.
^
Athletischer
Fuß
Der medizinische Name
für athletischer Fuß ist tinea Pedis, er beschreibt ihn und seine
Ursache am besten. Tinea
bedeutet Pilz, und pedis
des Fußes. Aber
ich bitte Sie, zu realisieren, dass
der „athletische Fuß“, ein ganzes Set an Symptomen beschreibt, aber
nicht die Hauptursache. Der Pilz an
sich verursacht die
Fußkrankheit nicht. Da
Pilz ein Parasit
ist, benötigt er ein
ordentliches Medium, um zu gedeihen. Die Haut des Fußes, eingehüllt in einen
heißen Schuh, mit der Hitze, welche das Pilzwachstum ausbrütet, ist ein
hervorragendes Medium. So wie ein Pilz im Oberboden wächst, lebt und wächst der
Hautpilz auf toter Haut, auf toter Haut von Hühneraugen und Schwielen. Er ist
vorhanden auf den Füßen hunderttausender Menschen, allgemein mehr bei Männern
als bei Frauen, da Frauenschuhe eher offen sind, und die Ableitung der Hitze
beim Gehen erlauben.
Wird eine Person
infiziert, zeigen sich die Symptome schnell als Skalierung zwischen den Zehen, und
entlang der Grenzen der Fersen, und entlang der Längswölbungen. Es tritt Juckreitz,
so wie Mazeration auf, mit
Faltenbildung , und
sich schälender Haut.
Das sichere Zeichen
eines athletischen Fußes
sind winzige Blasen,
die in Gruppen
auftreten, und wenn
sie aufplatzen, kreisförmige,
glänzende, rote Bereiche auf der Unterseite zurück lassen. Die Symptome sind
bekannt, dass sie von einer warmen Saison auf die nächste, in 80 Prozent der Fälle
wiederkehren; die Krankheit ist bei vier von fünf infizierten Personen
chronisch. Es gibt bereits eine exzellente Behandlungsmethode in Form von
antifugalen Mitteln, die auf den Fuß
aufgetragen werden, mit
DMSO als Transporteur. Diese
Lösung durchdringt die
oberen Hautschichten, und schickt
das antifugale Mittel
tief in das
Gewebe, um jeden Pilz
an der Oberfläche, oder
in der Haut abzutöten.
Zusätzlich ist DMSO selbst
eine fungizide Substanz, welche die Symptome des
athletischen Fußes stoppt, durch das verhindern des Wachstums
des nerventötenden Parasiten. Um sich selbst zu helfen, den athletischen Fuß los zu
werden, ist die Prozedur, die auch von
Mitarbeitern des Gesundheitswesens angewendet wird, die infizierte Haut zu
bearbeiten, mit dem geeigneten Heilmittel für den athletischen Fuß, und für die
Symptome, welche Sie behandeln wollen: eine Cerme für wunde, ungeschützte Hautoberflächen;
eine Salbe für verdickte skalierte Bereiche;
eine Flüssigkeit für ungeöffnete Blasen. Anschließend bedecken Sie dieses Heilmittel
mit der passenden
Form an DMSO:
einer Creme, einem Gel,
oder einer Flüssigkeit. Benutzen
Sie nicht weniger, als die 70 Prozentige Stärke an DMSO für eine effektivere Penetrationsleistung.
Die Beschwerden sollten in kurzen Zeit nachlassen, und möglicherweise nicht wiederkehren,
speziell, wenn Sie dieses Heilmittel zur Hand haben.
^
Fußgeruch
Fußgeruch, eines
der lästigsten Probleme,
ist weder schmerzvoll,
noch infektiös, und wissenschaftlich bekannt als Bromidrose. Bromidrose
resultiert nicht notwendiger Weise aus einem Mangel an Sauberkeit. Wo ordentliche Fußhygiene helfen würde, ist
Fußgeruch wirklich ein psychologisches Problem. Die Menschen, die an ihm
leiden, sind Subjekt von schmachvollen
sozialen Situationen. Die Hauptursache
ist eine funktionelle Störung des
Nervensystems. Es ist mehr als das Waschen der Füße notwendig, um Linderung
zu schaffen, und die Belästigung zu eliminieren. Die Symptome von Bromidrose
sind, den deutlichen Geruch beiseite gelassen, eine Aufweichung der Haut
zwischen den Zehen, sowie eine Empfindlichkeit des Fußfleisches. Es können sich
auf den Fußballen, oder auf den Fersen winzige Blasen bilden. Fußgeruch
verschwindet nicht schnell durch eine Behandlung. Wie auch immer, es gibt
Methoden, die das Problem verringern, und sogar komplett eliminieren. Das Einstreichen der Fußsohlen
mit DMSO ist möglicherweise eine von
ihnen. Obwohl es so erscheint, als ob Sie lediglich den einen schlechten Geruch
gegen einen anderen tauschen, wird
der DMSO Geruch in einem oder zwei Tagen
verschwinden, und den
Fuß zurück lassen,
ohne seinen eigenen
schlechten Geruch— wenigstens eine Zeit
lang. Je länger
Sie das DMSO darauf
behalten, um so länger bleibt
der
Fußgeruch weg. Nebenbei möchte ich anmerken, dass
viele Menschen dramatische Linderung ihrer „riechenden Füße“ erfahren haben, durch das
Entfernen von Zucker von ihrer Diät,
und durch die adequate Einnahme von Vitamin B Komplex, und eines Zink
Nahrungsergänzungsmittels.
^
Tänzerfuß
Tänzerfuß
Tänzerfuß is inflammation, and in severe cases, a shift or
break the two small bones that are below the head of the first metatarsal. And
as you suspect it occurs most often in people who dance a lot. The sesamoid
bones are located in tendons, which run under the joint of the big toe. Their function
is to reduce friction when the big toes move. Abnormal Stress can hurt these
two small bones. Dancing brings an unusual burden on the sesamoid bones, which
can be damaged. Inflammation and pain compromise the ability of the dancer. If
he or she ignore the pain, can break the small sesamoid bones, or moved. This
can happen with everyone, not only for dancers.
In treating this foot problem, a diagnosis is mandatory.
Then, a useful padding of the joint is carried out to measure the reduction of
inflammation to the physiological therapy. DMSO, ultrasonically bonded has
proved excellent, as a special form of the physiological therapy. She
immediately takes the inflammation from the sick Tänzerfuß. A padding is
applied, after it has been placed on the foot in the shoe, or as part of an
orthosis, in order to protect the sesamoid bones from excessive stress.
^
metatarsalgia
Metatarsalgia or Morton's Toe is a sudden, sharp, stinging
sensation of pain in the toes. The Morton's Toe comes from an inflammation of the
nerve of the third and fourth metatarsal, which causes a nagging feeling.
Runners are sometimes the victims of this neuralgic pain. Metatarsalgia is
caused by the compression of a small Zehnerves, between two shifted
metatarsalgischen bone. Inflammation occurs when the head of a bone
metatarsalgischen is pressed against the other, and it gets nerve between. At
each step, the nerve is rubbed, pressed, and irritated. Consequently, the
involved nerve is increased by a sheath of scar tissue, which shapes itself to
protect him. The tissue increases in a neuroma, which must be possible
surgically removed in order to gain complete freedom from pain. The Podiatrist
may procure the Mortonschen toe relief by applying other techniques than the
neuro shuffle surgery. This can be done through injections with local
anesthetics, which are mixed with DMSO, in the foot. A pad can be placed inside
the shoe to keep the metatarsalgischen heads mutually apart. Or it can orthotic
devices are worn by the patient. The Podiatrist be careful, and injected very
slowly because intramuscular injections may cause pain, although the local
anesthetic tends to conceal this. A good technique is to avoid discomfort to
the patient.
^
fallen arches
The so-called fallen arches are in fact weakened feet that
are so overworked that they have developed symptoms. In the classic case of
Senkfußes, almost all bones of the foot have changed their position. The heel
bone rolls inwards, ankles settles, the tibia is striking, the cuboid bone is
forced outwards, and both big toes, and the fifth toe to rise. The other bones
sink down, and the inner longitudinal arch falls. The victims feel pain and
burning in the feet, and fatigue, and sharp pain in the legs. You can neither
walk nor stand, over any period. Painful calluses can grow on the ball of the
foot, since the front metatarsalgische Bow also drops. Examine yourself on
flattened arches, through the control of your feet on flat. Or, imagine a
mirror and watch the back of your feet. Note whether the Frese tendons have
bent inwardly toward each other. This is the Helbische characters.
Relieving pain through the sunken arches can be achieved by
treatment with various devices that have been developed by professional
podiatrists. The Podiatrist can restore the normal function of damaged muscles
or Ligamentenin three steps again:
1. Physical therapy using DMSO and ultrasound in order to
reduce the inflammation.
2. Application of a corrective tightening
3. Manufacture of deposits for weakened feet.
As long as they have the problems and determine their
seriousness, how effectively the three-DMSO will be treatment. Realize Please
note that if nothing is done to guide the sunken arches, there will be periodic
episodes of pain, and that the symptoms are treated, disappear and reappear.
DMSO seems to be highly effective in acute foot problems, but hardly effective
in chronic foot problems, except in chronic calcaneal heel inflammation.
^
Heel Spurs
At the heel bone, the calcaneus, sometimes forming a
spur-like Gewüchs of calcium, where muscle and ligaments of the foot are
attached. One or more spurs grow on the heel bone, but are covered with
Fußfleisch so that it takes years until the spur is a problem.
The heel spur hurts when you enter your weight on the bones.
Anyone can be affected. Women suffer just because as men. He often seems to
occur in people over 40, and the complaint may be accompanied by arthritis or
poor circulation.
The underlying cause is the chronic strain of the foot
caused by weak feet, prolonged standing, improper footwear, or structural
misalignment of the feet. In any case, the feet are insufficient for the tasks
that need to meet them, and congestion brings physiological changes, such as
the overgrowth of the calcification. The pain usually comes not from the spur,
but by the inflammation of the muscles that are attached to the bone. It's
worst when you go start again after a rest. For absolute relieving painful heel
spurs, the doctor will diagnose the problem and analyze, and suggest a course
of treatment. This should ultrasound and DMSO are used to enclose and every day
to remove the deep-seated pain of inflammation. The airtight DMSO covering
technique is excellent when it wraps around the heel, to pull the painful
inflammation out.
^
ankle sprains
The Sprained ankle, a general injury is the result of a
violent twist of the foot. One can an ankle sprain if you walk just down the
street. You can sprain it when you climb on uneven ground, such as a rock or a
curb, when you start with a high heel in a grid, or when you jump from any
height without. The more active you are, the greater the possibility that you
sprained a joint.
A sprain occurs when the foot is rotated, it most often
occurs when the foot is somehow out of balance. If the weight of the body then
acts on the foot, it is, instead of being transmitted directly to the floor,
collected from only one side of the foot. The sprain will take place on the ligaments,
when the foot is out of balance, and the weight shifts suddenly stronger than
it can stand it the ligaments. Consequently, tearing the ligament that connects
the talus to the tibia. The violent the ankle was turned, the greater the
damage and the pain. you experience the signs and symptoms of the injury
immediately after the sprain. Each direct charge of the injured foot can cause
pain. If it is a mild sprain of the ankle is sensitive and delicate. If it is a
severe sprain, the ankle is hot, swollen, sensitive, and painful, so you can
not walk. The ankle turns, sometimes red, sometimes blue. When reinforced the
swelling, this is accompanied by throbbing.
The emergency treatment of a sprained joint can start before
going to the doctor. First you take the weight off the ankle. One sits down. If
the pain is really difficult, this proposal is hardly important for those cases
in which walking causes considerable pain. But you can make something remission
within a few minutes, by metering the torn ligaments, or pulled muscle with
90-percentage DMSO. It can burn something, or redness occurs, but the pain of
inflammation is soft from the ankle.
Enter still no weight on the ankle. The seriousness of the
injury can not always be detected immediately, the symptoms are not all visible
at once. The sprain could be considered only as a temporary disability,
especially after the rapid administration of topical DMSO, but the use of the
joint can easily exacerbate the damage. Do not take the risk.
The DMSO is reduce the swelling, or prevent it occurs at
all. Devise a proper support for the joint, such as wrapping the cloth
moistened with DMSO skin with a Zurrverband and cover it with a dense kitchen
plastic wrap to paste them firmly with tape or something similar. Remember that
not also mean the elimination of pain, the healing of the sprain; Support is
mandatory to keep the twisted ligaments against the leg bones so that they do
not move too much. Change the Zurrverband every four days, wash the skin every
time you emphasize this again with DMSO, and make this procedure continues
until no more pain at direct printing occurs on the Palpulation through your
fingers.
The majority, who suffers from foot and leg problems to many
gadgets used to, rather than to seek professional help, such as specific
materials and patented drugs, which are widely advertised as cures. Most of
these products are, unfortunately, ineffective; some were spun which offer in
the offices of advertising agencies this. Others are "family recipes"
that have been passed down from generation to generation, their new names were
given, they are artfully packaged and traded at high prices. The money that you
spend Gadgets for walking, is often completely wasted. Until
now, the public wanders from one remedy to another, in their never-ending
search for relief. There is no panacea. The only true effective products for
use on the feet are the ones that have been tested and tested in laboratories,
clinics, and doctors' offices. Until now seems a medicine to be most-nearly
applicable for foot and leg problems as a panacea, it is DMSO. It is applicable
for a wide range in difficulty of the lower limbs, and can be used as an
excellent emergency remedies, as well as subsequent therapy for many problems
that plague our feet.
^
Chapter 9
Chapter 9
The use of DMSO for injuries of the head and spine
Clara M. Fox from Toutle, Washington, was stunned to learn
on 15 September 1979 that her son Bill suffered a near-fatal injury which
paralyzed completely the young man. After a series of alternating Hospital
while William J.Shaal the first six hours was taken to the University of
Oregon, the Health and Science Center in Portland, after his accident. It was a
lucky move, because DMSO is a therapeutic additive, which comes on the surgical
intensive care unit of the institution used. George Greccos, M.D., the
physician who was in charge of Bill Shaals case, led an intravenous infusion of
the experimental means by, as an integral part of his treatment during the
first ten days.
Bill had broken neck, he was paralyzed from the site of
injury. He could not urinate yourself, defecate, move any limbs, talk, eat, or
perform some other type of voluntary function. At its clean shaved head ugly
but necessary steel tongs were screwed into his skull to immobilize the spine
column. Thin ropes and pulleys with weights were attached to stretch his neck
up to the decisive point, to bring it to the original state, and to heal
possible way. He remained in traction for 45 days after he came out of
intensive care, where he was treated for four days between life and death. The
teenager was about six months in the hospital. Spinal cord injury are extremely
serious, and lacerations or cuts across the strand, let the victim necessarily
permanently without function. An acute transverse spinal injury, caused an
immediate enervating paralysis, and the loss of all sensations of the
vegetative system, below the line of injury. The paralysis gradually changes in
hours or days to a spastic Paraphlegie due to the exaggeration of the normal
stretch reflex. The limbs develop spontaneous leaps or spasticity. Later, when
the mainstay in the lumbosacral region is not completely separated, appear
spasms of stretching the muscle or flexor muscles, and deep tendon reflexes and
autonomic reflexes return gradually.
Depending on how complete is the trauma of the spine, only
partial motor and sensory nerve loss may occur. Voluntary movements can return,
but they are unregulated; sensory losses are dependent on what is affected part
of the backbone. The lost or impaired preferential senses can affect the sense
of posture, vibration, Lichtemfindlichkeit or pain, the temperature, and the
sense of touch. A half cut through the backbone causes spasticity, the loss of
the sense of posture of the page that has been severed, and the loss of the
pain and the Temeratursinnes on the other side. When an injury is sustained, as
the young Bill, the backbone of the serious damage may not recover, and often
is this permanently. Therefore, if occurring in the first week after the injury
movement or feeling, these are favorable signs for some rest. Each malfunction
that lasts six months remains permanent. A severe spinal injury on the fifth
cervical vertebra which is usually fatal. Bill was at this point. Certainly
occur motor and sensory loss, and the reflex arcs that control the bladder, the
sexual activity in men and bowel function, are destroyed. Although the DMSO
acts effectively in curing Rückgratlverletzungen, when administered
intravenously within 90 minutes after the injury, Bill Shaal the received DMSO
only seven hours later. Nevertheless, after several days he got significant
feelings in his shoulders, arms, in his upper chest, and even in his nipples.
His family was overjoyed to be able to observe the return of his senses, Clara
Fox said: ... and before the agent was deposed, he was able to experience
emotions and surprises in his bladder and kidneys, when he tried to urinate
again and again, and also could urinate. Of course, you can imagine the joy
that occurred with each new discovery. This was phenomenal because Bills
problem was so serious that Dr. Greccos when he met the family who first came
to the hospital, showed them the radiographs, and told them that their son
would be dead. He said that the main cause, the Bill has made it at all, would
be due to his excellent physical and menthalem state. The doctor added bluntly
added that if Bill would survive, he would undoubtedly remain paralyzed for the
rest of his life, downstream from the site of injury in his neck. During the
course of the first two weeks, the patient fended off three bouts of pneumonia,
and a very malignant inflammation of the urinary tract. It is not uncommon for
victims of cervical spine injury, the difficulty breathing and bladder problems
with them. The family members of the patient and the doctor, realized, however,
that the DMSO has literally saved the young man's life in which he ceased, the
liquid and the pressure of his spine, and head while slowly the feeling in his
body restored. Without the intravenous administration of the agent he would
probably have died.
Many of the cartilage in the patient's neck had
disintegrated. Bill needed an operation in this area to provide a remedy, and
this was carried out five weeks after the hospital staff had deposed the DMSO
with him. The surgical procedure, which comprises implanting two stainless
surgical rods in the back of his neck with einbezog, was combined with a little
bone and muscle, which were removed from his left hip.
The operation was definitely successful.
A physical therapy program has been incorporated as a part
of the rehabilitation process, however, held postoperative pain the patient
from carrying out it. He would have needed more passion to practice, but these
could not be found. As the days passed, he deteriorated slowly, and the young
man and his mother realized that there was a need to take intravenous DMSO
treatments again. The only thing, which allowed the hospital staff, were some
topical applications of the composition to the
aching areas in his neck, shoulders, arms, and other parts
of the body. DMSO to the skin minimizing the pain. Then some family members
noticed light and flowing movements in Bill's legs, as she auftrugen the
solvent. His mother described the movements of the hospital staff, but their
descriptions were dismissed as the possible spontaneous hops or spastic
paralysis of the hemisection of the spinal column. The nurses and medical
students, in this hospital ausbildendem summarized the movements on a simple
natural Fußspastiken which occur from time to time.
"Then one day made one of his feet such movement while
Dr.Greccos stood by him, to talk to him. The doctor came out of Bill's room
with a look of awe and wonder, and stated flatly that he knew now, about what
we were talking, and he agreed immediately so that a via which this would not
be regular spasticity in fact, but something quite different than what you
would speculate in the coming weeks. "said his mother." about three
months, since they have discontinued the DMSO at Bill we fight every day about
that intravenous procedure continues, without much success. But we did it
finally, just before the Christmas holidays, they agreed, but under safe
conditions. The medical staff wanted the patients to move across town,
neurological for a series tests that should be performed with special equipment
at the Good Samaritan Hospital. If these tests indicate any hopes of a
noticeable improvement which could be the DMSO attributed, they would give him
the means again for a few weeks. Then he'd returned to the Good Samaritan
Hospital, and the next series of the same tests would be carried out again. If
there were no significant changes, the intravenous administration of DMSO would
be discontinued. "From this point on," reported Mrs. Fox "Bill
improved quickly and constantly to have up to the point where he is now a
maximum of occupational and physical therapy managed daily for three to five
hours without pain; he was almost exhausted, as it so hard work on himself. He
rose when lifting 2 ½ pound weights by his right arm and wrist to 15-16 pounds;
and by 1 ½ with his left arm and wrist to 35-40. Because the was able to
achieve this, he held out his triceps (muscle) in the right arm restores that
were stunted by then, and I would make a very good biceps add on which he is
extremely proud and would be willing to take on anyone in a wrestling match.
And slowly but surely, the right triceps recovered, and we are full of
confidence that he gets back everything he had once back earlier. "
On 13 März1980 Bill was returned to Good Samaritan Hospital,
to repeat the previous tests. The results were nothing short of astonishing.
All Interpretations of the earlier tests indicated his dramatic improvement. In
addition, the patient showed that he had sensory nerve sensations in his right
foot. The patient was restored almost to what it once was. He was permanently
discharged from the hospital.
Bill came home to eat in a position even to brush his teeth,
to shave his to dress, and bathe himself. Six months ago he was more dead than
alive, and the family was preparing for his lifelong complete paralysis before,
now the young man was able to use his manual wheelchair itself. Move Even a
month ago konnter the wheelchair alone. But intravenous injections of DMSO
changed all this. "During the last six months I spent many hours in Dr.
Jacobs Clinic, with its wonderful and umsorgenden staff who were able to
observe wonder of wonders, what happened right before my eyes," Clara M.
Fox wrote to Claude Pepper, the chairman of the Congress Committee on aging of
the house. "I have seen people who were 20 years or more totally
paralyzed, and when they were treated, they began to move. One can see the
amazement in their eyes. I witnessed the awe in her eyes, and the actions of a
young couple whose child was treated at Down's syndrome, and listened with rapt
attention, as they told how far the child from the door of death came up today.
I have people with different diseases or pain sent to Dr. Jacobs Clinic, or
they belong personally delivered and their laughter and their ultimate
satisfaction seen how this has been cured or helped them, after years of
discomfort and pain. And then I leaned back to see Dr. Jacobs absolute ecstasy,
according to a new successful case treatment. How proud and happy he was to be
able to help us humans. "I read a lot and researched, only all my hope in
prayers take on the whole and true story of this remarkable agent, and I can
together, along with many millions of others that this modest man can see
materializes all his work and dreams, in the final success, so that the DMSO is
retrieved by the FDA on the market, so that all Americans get a chance that
they will be helped, or they may be saved, by these efforts. I urge everyone to
be connected to this possibility, please carefully check all the facts, and to
help and to give this devotion of hearing. "
^
DMSO research on reversing neurological disorders.
DMSO research on reversing neurological disorders.
The laboratory experiments continued, where DMSO was used to
treat simulated injuries which were caused in the vertebral columns of monkeys.
Under ideal conditions, the external factors and the reproducibility of the
violations of monkeys are strictly controlled, and "the effects of DMSO
were often dramatic, sometimes unusual and rarely without effect," said
Jack.C. De la Torre, Sc.D, M.D., Chief of the Department of Neurosurgery,
Medical School, University of Miami, in Miami, Florida. He was interviewed at
the biannual meeting of DMSO Society of Florida, Inc, which was held in
Sarasota, Florida, in November 1980. "The important question of our
research of the present time is not whether the DMSO acts, this has been
repeatedly shown in our laboratory, and in the laboratories of other, but ...
how does it work? "
Dr. de la Torres experience with DMSO comprising now 24
years old, and includes fundamental, as a clinical research with. He
experimented with head and spinal injuries, strokes, burns, urinary excretions,
respiratory stimulation, brain swelling, and the cellular mechanism. He used
seven different animal species, including human beings. He discovered that the
DMSO exerts a positive effect on a number of life-threatening ailments,
including head and spinal trauma, celebraler embolism, and difficulty
breathing.
Neurological head and spinal injuries, and stroke are
complex medical problems. Despite the wide range of application of DMSO makes
this useful in many of these cases. Through a combination of increased
diffusion of fluids through the body membranes and dehydration, the solvent
alleviates the damaging swelling, and the pressure that often accompanies head
and spinal injuries. This relief arises because the substance is the skin
barrier and the blood-brain barrier crossing. The blood-brain barrier is a
protective mechanism that exists between the circulating blood and the brain,
which limits the number of molecules which reach the brain. They protects from
foreign proteins, natural body proteins, and the occurrence of other
substances, some of them may be toxic to the nervous tissue.
"At first we thought that this property of DMSO could
be a disadvantage," said Dr.de la Torre, "because we felt that it,
once it has penetrated the barrier, is simply stored in the nerve tissue, and
more swelling would cause. What makes it really, is that it enters the tissue,
madly absorbs water in order to rush out of the system by releases pressure.
"
The ability of DMSO rapidly the skin, as well as to cross
the blood-brain barrier allows him to help, which was already rather stressed
during penetration of other agents. "As an example, some tumors in the
brain had to be treated by chemotherapy injections. High doses had to be
injected before the funds began to take effect, and at this point, the toxicity
of the agent to kill the patient, "said de la Torre." If you have a
substance such as DMSO, which in the anti-cancer agent can transport the tumor,
and in the area immediately surrounding, you can use reduced levels of the
chemotherapy agent. "
Because DMSO can penetrate skin barrier with ease, but the
cells not damaged, DMSO is itself a class of a new healing principle.
Furthermore, it protects cells against mechanical damage.
Ramon Lim, M.D., associating professor of neurosurgery and
research, associating in biochemistry at the Medical School of the University
of Chicago, led by some experiments in which he used DMSO to glial cells. The
supporting tissues of the spine and brain consists of glial cells. Dr. Lim
prepared cultures of glial cells and DMSO, which he exposed sound vibration.
DMSO protected the cellular membranes before the breakup by the vibrations, it
protected the components of each cell. For example, the bag-shaped Lysome
located in each cell would release enzymes that are harmful to other cellular
systems, if they would escape from the confines of their parent cells, and
would therefore aggravate swelling and pressure. If DMSO is instilled into the
cells, is that enzyme loss through the cells does not take place, as evidenced
by Dr. Lim experiments with glial cells.
Much of the permanent neurological damage in a brain injury
and stroke, is caused by the reduction of blood flow in the brain. An
interrupted blood flow results in an inadequate supply of oxygen and nutrients
the brain tissue. DMSO supports a better blood flow by reducing the
Trombozytenklebrigkeit and the accumulation of clumps formations. these are
normally states, which can clog arteries and veins. DMSO
stimulates the release of prostaglandin, which increases the diameter of the
blood vessels. It also inhibits the release of the other prostaglandin welchse
the vessels constrict and reduce blood flow. Dr. de la Torre emphasized that
the patient must have a spinal injury, which are candidates for treatment DMDO,
two criteria. First, the violation of the victim must be fresh if it is more
than a few hours old, the pathogenic consequences have been well established.
You will not be reversed by any means. "Been In our research DMSO and a
half hours the limit," said the neurosurgeon. "We do not know how
long this limit can be successfully delayed, since this depends on the location
and severity of the injury." The second criterion for a patient is that it
must have a so serious spinal injury that conventional treatments would make no
sense is excluded, and a spontaneous recovery. "Many patients come in with
a loss of sensory feeling, and even a loss of motor skills, yet they sometimes
recover without treatment," said la Torre. "If DMSO is administered
to such patients, there is no way out if their recovery is spontaneous, or
because of the agent." How can a doctor isolate patients who will not
recover by the onventionelle therapy? "We've got a test, called the"
somatosensory evoked response "," he said, "which measures the
activity in the somatosensory cortex in the brain once the Peripheral nerve is
stimulated. Should a permanent damage of the spine are made, no activity is
recorded. Because of our experience with laboratory animals, we believe that in
patients with no response may be the motor function will not recover. By undo
this non-recording of activity in the brain with DMSO, we know that we have
done something. "
^
The emergency therapeutic principle
When DMSO was pointed by his co-discoverer of the
therapeutic principle. It is a means that, for a number of diseases is
effective, which do not have a common denominator. "I think this comment
refers to the fact that very little research on the agent has occurred as a
pharmaceutical drug," says de la Torre. "The more we study it, the
more potential applications in a number of diseases, we will explore the
possible way when it is used alone, or in combination with other agents."
He believes that DMSO established its therapeutic benefits, without toxicity,
with a large number of serious health problems. He is of the opinion that it
should be carried in ambulances and paramedical units as emergency therapeutic
tool. "I think that would be extremely mandatory," said de la Torre,
"especially when we emphasize that these serious injuries of the spine and
the brain are permanently within four hours. One uses some established criteria
to assess the injury, whether a para medical DMSO administer or not administer
would, depending on each individual case. If we emphasize that there is no harm
in any state, it could be injected as a prophylactic agent, even with an
injury, which is thought at the moment that this is permanent. "The
neurosurgeon, and his former colleagues of the Department of Neurosurgery
University hospital of Chicago, Drs. John F. Mullen, K. Kajihara, and Henry
Kawanaga, observed some initial results from their work with the agent, and
reported this at scientific meetings. "We played the effects of DMSO down
always," said de la Torre, "because the agent had the label of an
undershot means. Doctors tended to meeting against each other with elbows to
work, and giggling to suggest: How can something be so good "Over time,
the pharmaceutical versatility of DMSO was ultimately confirmed by a number of
clinicians who have been experimenting privately with him?. "I no longer
see many doctors who still giggle; they begin to suspect that something is
behind all this, "said de la Torre. "I believe that if more people
learn to accept that it is not in DMSO to a miracle cure, but an agent with
many potential applications, they might be motivated to go into their
laboratories to do some of this work . "There is a need for more research,
for research that the FDA takes, before DMSO is released as an approved agent
for a greater number of applications.
^
Animal experiments in which DMSO is used in brain embolism
The disease in the brain occurs when brain tissue death by
cutting off the blood supply. The blood, which brings oxygen and nutrients
along with it, can be blocked by a blood clot, which is called thrombus, or by
a plug of clotted blood, or by foreign materials, which is called embolus. To
study the effect of DMSO on the gross manifestations of such occlusive brain
infarcts, twenty normal rhesus monkeys one sex are used in a laboratory study
of medical scientists from the Medical School at the University of Chicago and
the Medical School of Eastern Virginia which their recources and talents combined.
The symptoms of a brain infarction can be simulated in the monkeys by injecting
them air to trigger a celebral air embolism. You get cramps occur on sensory
changes, it show motor deficits on the eyes, they get paralysis as
Atemstörungen.2 This should currently not be overstated, since the monkeys were
specifically intended for use in laboratory research purposes. You are making a
very nice life until they enter the scientific methodology. Your contribution
is the health and life support of humanity.
The members of the group of monkeys whose average celebrale
artery was compressed in an experiment by a small Mayfield Klammer.3 The clip
remained for 17 hours in place. The DMSO treatment started after the fourth
hour, after these arterial occlusion, and was continued for between one and
four days. Monkeys that survived this procedure were sacrificed seven days
after initial closure. During the entire experiment, the animals were observed
by quantitative as laboratory and clinical tests produced the very positive
results on brain embolism. In human brain embolism caused by fatty deposits in
the large arteries that supply the brain. It can also arise pieces that break
off of thrombosis in damaged heart. These may result from deposition of
platelets, fibrin, and cholesterol on the surface of ulcerated plaques, wherein
the hardening of arteries; by the desolation of the heart valves, caused by
bacterial endocarditis; by mural thrombi with rheumatic heart disease, or
subsequent heart attack, or clumping, resulting from open heart surgery. Brain
embolism can meet divers suffering from decompression sickness. If the blood
supply is interrupted by one of these emboli for more than a few minutes, then
dies from a part of the brain, and the neurological damage is permanent.
An acute stroke is another manifestation of a blockage of
the blood supply to the brain. So a zerebrovasculäre disease is the leading
cause of neurological disability in Western countries. They usually arises from
the hardening of the arteries, high blood pressure, or a combination of both.
Stroke meets someone suddenly, with symptoms and signs that reflect which area
of the brain is damaged. The closure of either the inner kartoiden, and the
average the cerebral artery, which was carried out in monkeys, can produce a
range of severe neurological abnormalities, such as those that occurred in the
monkey.
DMSO prevents or reverses the pathogenic sequences, which
result from the zebralvascularen insufficiency, which ultimately bring a local
death of brain tissue through the embolism itself. The agent must reach only
fast enough to the site of injury. DMSO stimulates the synthesis of
prostaglandin, what the potential damage that occurs in brain infarcts, is, or
reverses. Prostaglandins (PGs) are a group of cyclic fatty acids which possess
diverse and potent biological activities that affect cell function in every
organic system. PGs have sedative, hypnotic and anticonvulsant effects on the
central nervous system. DMSO increases the oxygen which is available to the
brain tissue, by the extension of other blood vessels, which lie next to those
that have been blocked by an embolism.
DMSO also helps in releasing of energy, and allows the
ischemic tissue sufficient time to obtain a hemostatic balance and returns to
further damage to the cells of the central nervous system, or prevents this.
Other experiments in dogs showed that significantly better behaved with
DMSO-treated animals than untreated control animals, as they were subjected to
experimental acute spinal cord injury. The recovery rate of the animals was
associated with the initial dose of DMSO, which has been administered, as well
as the time interval of the elapsed after the injury before the agent has been
administered. High doses, as well as previous treatment resulted in much faster
recovery. As 40 rhesus monkeys of acute experimental head injury were exposed
by compressed them the brain by means of an extra dual balloons, joined by a
variety of symptoms. As DMSO has been administered to these animals died less
and the neurological defects in the surviving animals were less apparent than
with the control animals. The scientists who carried out these experiments,
studied the effect of DMSO on serious head injuries, such as brain compression.
Brain compressions may be caused by weapons from serious head injuries such as
gunshot. "We have no medicines to treat the most severe head injuries
adequately," said de la Torre, "and there is great hope that DMSO is
able to fill this gap, at least until we learn more about the pathogens that
involved in these injuries is to learn. "
Summary of knowledge on the application of DMSO to the
central nervous system
Summary of knowledge on the application of DMSO to the
central nervous system
^
During his appearance in March 1980, before Kongressauschuss
for aging processes, candied Dr. de la Torre his experimental work with DMSO.
The questions, which he answered, almost bordered all along, which is currently
known about the adjustment of the composition of disorders of the central
nervous system. Over the years, thousands of laboratory animals were used in
dozens of experiments to accumulate suffizientes knowledge before you began the
solvent in humans. Alone the de la Torre group led the DMSO treatment to more
than 500 animals by, at four different species, as well as many luxurious
models of neurological trauma, dated since early 1971, as head and spinal
injuries were explored. The following information comes from the testimony of
the neurosurgeon: The injured animal enters an improvement of cortical flow
within 30 minutes after the administration of DMSO, even after cortisone
distribution was stopped. Cortisone is a natural body substance that helped the
experimental model to fend off the effects of head trauma. By infusion of DMSO
is an increase of blood flow in the carotid artery to the brain. The carotid
arteries are two cerebral vessels, which bring oxygen and nutrients to where
they are needed. This circulation mechanism is shut down by the trauma, and
constituted a kind of brain death, without the infusion of DMSO. DMSO-treated
animals responded much better than those animals who have been given anything
else wurde.DMSO seems the Elektronenzephalogramm of the person concerned to
re-establish. In this model injury, the animals were brought to a point at
which the measurement was Elektronenzephalogramm flat, as in any preceding
Gehirntod, or eventual death of the animal. Ten minutes after the injection of
DMSO the Elektronenzephalogramm returned, and the brain was active, by his own
healing and own thinking.
Elevated blood pressure was stabilized at this DMSO-treated
animals. This is important because when performed spinal or head injury always
an increase in blood pressure occurs in humans and animals. Can not be
controlled of being ascended blood pressure, this may result in death.
There is an increase in the breathing pattern of the injured
models which use DMSO. The animals seemed deeper and breathing more quickly, a
desirable effect, since in many brain injured patients breathing falters and
stops eventually. When urine output, DMSO produces a diuretic effect, and
increases the excretion of the body to a fivefold compared with other drugs.
After intravenous administration of DMSO there is an increase of the blood flow
in the spine, to the region of trauma. One of the first things that happen is
for a spinal trauma that a reduction of oxygen and blood flow using, be in the
concentrated or shut down the blood vessels and thereby reducing the secretion
of important enzymes or other materials is prevented to the tissue that.
Without treatment, the fabric then swells. This may lead to paralysis. If the
cerebral stroke the animal either falls into a coma, is teinahmslos, or dies.
By an infusion DMSO, immediately after the injury, all that is prevented. The
brain is a result accumulated from the trauma of water because of damage
destroying many of the cells. They distribute their components into the tissue,
increasing the water content, and therefore the pressure in the brain. This
fluid builds up in the skull on which is no more than a bony container, which
may compress the vital centers at the bottom of the brain, and leads to death.
However, medical researchers have observed that treatment with DMSO causes a
significant reduction of intracranial pressure. "If DMSO would effectively
reduce only the intracranial pressure," said de la Torre, "it would
be a very useful drug ....... It absorbs water and carries it to the blood
vessels, and removed it then from the brain. It dries the brain in a way right
out. "In the same way, a blood deposition, which compresses the tissue in
a vital critical area, causing irreversible brain damage, however, is
transported away DMSO this non-toxic blood. Experiments, which were conducted
in 1992 at the University of Health Sciences-Medical School of Chicago have
demonstrated the reduction of scattered blood, but the researchers could not
explain how the injected DMSO accomplishes this. They theorized that the
perfusion of the blood vessels in other areas, by the action of DMSO, the
function of the damaged blood vessels would take over.
DMSO tends to protect nerve cells from the current physical
disorder that occurs after the injury. It offers better protection than other
treatments. Scientists have this verified by observations with the electron and
light microscopy. Consequently DMSO prevents the paralysis that follows a
trauma; it prevents or reverses many of the pathogenic signs, which normally
occur in a brain trauma; it corrects the serious effects which occur after an
embolic stroke. This would be advantages which any manner could affect more
than half a million Americans each year.
^
The potential in the treatment of myasthenia gravis,
and other disorders
To proceed with the demonstration of the great effectiveness
of DMSO in the treatment of central nervous system, projected de la Torre, as
it would open up possibilities for treating other neurological disorders which
relate to brain swelling. For example, the substance is already being used in
the treatment of the consequences after removal of a brain tumor, wherein after
the removal of the tumor, a swelling of the tissue occurs. In children with
Reye's syndrome, acute Einein Antieg intracranial pressure occurs presumably,
by the penetration of viral material. The surgical or drug therapy is in the
Reye`s syndrome often ineffective, however, DMSO could take over the task to
reduce the pressure in the brain of the child. Normally antibodies protect
people against disease. In Myasthenis gravis, however, hinder abnormal
antibodies the transmission of nerve signals to the muscles, and therefore
produce the weakness as symptoms of this disease. Masthenia gravis, a rarity, a
true of 20 000 people. It is characterized by sporadic muscular fatigue, and
weakness, which occur mainly in muscles innervated by cranial nerves, and
characteristically reduced by Cholistenerasehemmende drugs.
It is believed that the causative defect is located at
the neuromuscular junction, such as that of a limitation on the ability of
acetylcholine to induce a muscle contraction. The DMSO, a cholinesterase
inhibitor, the abnormal antibodies significantly reduced, and thus the
characteristic of myasthenia gravis. In animal studies at Johns Hopkins
University DMSO was simply used as a solvent, which tested the absorption of an
immunosuppressive drug, which was called Frentizol researchers. Their task was
Frentizol apply to reduce antibodies in rats, which have been treated so that
with them a disease similar to myasthenia gravis occurred. The experimental
treatment worked, but proved that the DMSO carried out the procedure, not the
immunosuppressive drugs. In January 1981, scientists Alan Pestronk, MD
reported, and Daniel B. Drachmann, MD, in the British scientific journal
Nature, of its intention to DMSO for testing on human beings, because they knew
no simultaneous treatment reduced which circulating antibodies, so fast safely
and effectively as DMSO made in the experiments. The scientists emphasized that
their observations were made at only one series of experiments with a species
anyway. They did not know whether the same effect occurs in humans, or whether
the DMSO would have any value against this disease. This should werden.Dr still
under investigation. Pestronk and Dr. Drachmann said their discovery could have
important implications not only for the treatment of myasthenia gravis, but
also in other diseases, which directs the body's immune system against the
body's own cells or tissues. Such disturbances are called autoimmune diseases.
Various other serious disorders, including rheumatoid arthritis, include
autoimmune factors.
^
Treatment of intracranial hypertension
In the June issue of 1974 of the journal Neurosurgery
described three neurologists their application of DMSO to intracranial
hypertension (high blood pressure within the skull chamber) to reduce in a head
injury. They discussed their experience in six patients, two were given a large
administration at a time, an intravenous "push" injection of ten
percent Dimethy-lsulfoxid, and four were given a 20 percent solution titrated
measured by count of drops against the intracranial pressure (ICP ) Five of the
patients of this group suffered a severe head injury, and one had a cortical
vein thrombosis (blood clots of a vein of the cerebral cortex), the result of a
pregnancy. The first two patients were treated solution with a rapid infusion
of a 10 percent DMSO. Initially, the ICP was satisfactorily controlled by this
method. After some time, however, occurred in an overload of fluid, severe
electrolyte disturbances, and an ultimate loss of control ICP. In the following
patient a 20 percent solution against the ICP was titrated. Although the ICP
control improved by applying this method of administration, in turn, problems
occurred with the control of electrolytes and fluids, although the three
clinicians were heavily monitored.
In addition, since the properties of the solvent DMSO, and
its tendency over time to dissolve the most recognized intravenous infusion
systems (to reduce their potential, or the concentration), were mechanical
problems on the administration in all six patients. In their clinical Journal
Report write the doctors: "The mode of action of DMSO is not well
understood. It differs from the barbiturates, but it acts rapidly, to function
alone as a diuretic. The agent is extremely complex to apply, and the difficulties
with its administration could its risks enlarge ultimately, as its potential
benefits. Until more laboratory data concerning its use are available, and
better delivery systems are available, I would like to warn against
neurosurgeons to treat intracranial hypertension with DMSO. "
^
Multiple sclerosis treated successfully
DMSO found in Russia use in the treatment of multiple
sclerosis, which was announced in a clinic Journal Report of 1984th 34 patients
with multiple sclerosis treated with the Russian product Dimexide. (Dimethyl
sulfoxide) The use of the product was as desirable entfunden because it had a
positive effect on the immune system, such as an anti-allergic and reparative
action on the injured tissues.The treatment proven to be most effective in
patients with a remitting course of the disease. In patients with a rapidly
progressive course the improvement was unstable. Keinerle
Side effects were observed. The beneficial therapeutic
effect could be explained by remyelination (regrowth of nerve sheaths), a
reduction of edema (swelling), and a neuro dynamic enhancement (Enhanced
Movement of nerve impulses). No toxicity of the DMSO in the treatment of the
central nervous system in all studies of its groups Dr.de la Torre found no
significant toxicity associated with the agent, even at high intravenous doses.
He explained: "We used a series of rhesus monkeys What the people are very
similar pathological ind them injected high doses of DMSO intravenously, over 9
days. Before and after that we tested the serum chemistry of these monkeys
whose cardiovascular reactions whose neurological symptoms, as well as their
ophthalmologic changes which should have occurred. "Following the
toxicology studies, which lasted 18 weeks, we came to the conclusion that no
significant changes in serum chemistry occurring at any time during the
observation period. These changes were compared with a group of control
animals.
"There were no changes in the urine, and there were no
neurological changes. There were no cardiovascular changes. There were no
ocular changes. We were eager to see if some changes in the refraction or the
light transmittance of the lens would occur because it was reported a few years
ago, there? This problem occurred in rats. "One of the ophthalmologists
checked these animals before and after DMSO, he did not know which of the
animals had received the funds, and it was confirmed that no changes in all the
eyes of the animals had occurred. "Then the animals were subjected to the
following experiments an autopsy, and examined histologically the tissue. No
pathogenic changes were found on histological examination. "So is our
conclusion that the DMSO finally, the cases of these cases, an effective and
relatively nontoxic substance that when administered intravenously .."
"Our results with spinal injuries, brain trauma and stroke were in by at
least three different groups of researchers confirmed elsewhere in the country,
"said Dr.de la Torre." We believe that it is a highly effective drug
is in DMSO, for use in injuries to the central nervous system. "
^
Chapter 10
DMSO treatment for mental illnesses
DMSO treatment for mental illnesses
Melody Clark had her first psychomotor assessment when she
was six months old. Her parents, Mr. and Mrs. Dale Clark, of Wenatchee, Washington,
found that Melody is severely retarded, and would no longer proceed menthal at
best, as a six year old. She was born-one with an extra chromosome 21 Total
number of 47 chromosomes instead of the normal 46 when they man-made to a
victim of Down's Syndrome, or trisomy 21 patients with Down's syndrome are
drawn as trisomic Mongoloid, because various properties that are odd in an
individual with three specific chromosomes, rather than with a normal pair of
homologous chromosomes. Typically, the child was born to a mother older,
although the condition can also occur in babies of mothers of all ages. The
incidence is approximately one in 700 live births, but there is a variation on
the mother's age. In the younger mothers the incidence is approximately 1 in
2000 live births; among mothers over 40 increases this to about 45 per 1,000
live births. Nearly 50 percent of babies with Down's syndrome are born to
mothers over the age of 35th The babies tend to be quiet, rarely cry, and have
a lack of muscular tension force on. Your physical and menthale development is
retarded; the intelligence quotient (IQ) is approximately 50. Her features are
different from the normal: an abnormally small head, back flattened, and
disproportionately short; slanted eyes with folds of skin which extend from the
nose to the inner end of the eyebrows are available. There are gray to white
dots, like the grains of Sazstreuers are usually visible to the periphery of
the iris immediately after birth, and disappear in the first twelve months of
life. The nasal bridge is flattened, and the baby's mouth is often kept open by
a large, protruding tongue, which is furrowed, and it lacks the central
fissure. The hands of these children are short and broad, with a single palmar
crease. (Simian crease). Her fingers appear short, with a curvature of the
fifth digit, which often has only two phalanges. The feet have a wide gap
between the first and second toe, and a groove on the sole of the foot widens
backwards. Radiographs of the hips of children reveal reduced acetabular and
iliac angle, and before the availability of chromosome analysis, this was to
confirm the most important discovery to diagnosis. Congenital heart disease was
found in about 35 percent of Down`s syndrome patients. Thus, the life
expectancy is reduced by the treatment of heart disease, and by the
susceptibility to acute leukemia. Anyway, many young people without a capital
heart defect survive into adulthood, but not old age. As Melody Clark was
eleven months old, they brought their parents to DMSO treatment under the
guidance of Dr.Stanley Jacob. At this time, she could not stand, because her
feet were similar to those of a rag doll. She could not turn her back on her
stomach. Her eyes were constantly blurred; she was almost invisible in the
situation. At the age of eight to Melody a circumstance which is highly unusual
for this previously irreversible condition, developed from a difficult backward
child, to one that was-- remained mediocre. After seven years of DMSO treatment
ran and hopped Melody, they jumped about, and played on the trampoline.
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